PubMed İndeksli Yayınlar Koleksiyonu by Institution Author "Karaca Gencer, Hülya"
Now showing items 1-11 of 11
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Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
Turan, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties
Karaman, Nurcan; Zainel, Rabeah Adil; Kapkac, Handan A.; Karaca Gencer, Hülya; Ilgın, Sinem; Karaduman, Abdullah Burak; Koçyiğit-Kaymakçıoğlu, Bedia (Wiley-V C H Verlag GMBH, 2018)1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1-22) were obtained by the reaction of ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
Kaya, Betül; Hussin, Weiam; Yurttaş, Leyla; Turan, Gülhan; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)A series of 2-(4-substitutedmethylphenyl) propionic acid derivatives (6a-6m) were synthesized, characterized and evaluated for cyclooxygenase (COX) enzyme inhibitory and antimicrobial activity. Test compounds that exhibited ... -
New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors
Karaca Gencer, Hülya; Levent, Serkan; Çevik, Ulviye Acar; Özkay, Yusuf; Ilgın, Sinem (Pergamon-Elsevier Science LTD, 2017)Owing to the growing need for novel antibacterial agents, we synthesized a novel series of fluoroquinolones including 7-substituted-1-(2,4-difluoropheny1)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ... -
New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Öztürk, Yusuf (MDPI AG, 2017)Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substituted phenyl)ethan-1-one derivatives, ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Biological Evaluation of Pyrazoline Derivatives Bearing an Indole Moiety as New Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Karaca Gencer, Hülya; Tunalı, Yağmur (Wiley-V C H Verlag GMBH, 2013)1-(p-Methylphenyl)-3,5-diaryl-2-pyrazoline derivatives (2a-f) were synthesized via the treatment of 1-(1H-indol-3-yl)-3-aryl-2-propen-1-ones (1a-f) with p-methylphenylhydrazine hydrochloride in hot acetic acid. The structures ... -
Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
Abu Mohsen, Usama; Yurttaş, Leyla; Acar, U.; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Karaca Gencer, Hülya; Cantürk, Zerrin (Georg Thieme Verlag Kg, 2015)In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]- ... -
Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
Yurttaş, Leyla; Duran, Murat; Demirayak, Şeref; Karaca Gencer, Hülya; Tunalı, Yağmur (Pergamon-Elsevier Science LTD, 2013)In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the ...