Kurum Yazarı "Koparal, Ayşe Tansu" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Adhesion profile and differentiation capacity of human adipose tissue derived mesenchymal stem cells grown on metal ion (Zn, Ag and Cu) doped hydroxyapatite nano-coated surfaces
Bostancıoğlu, R. Beklem; Gürbüz, Mevlüt; Akyürekli, Ayşe Gül; Doğan, Aydın; Koparal, Ali Savaş; Koparal, Ayşe Tansu (Elsevier Science BV, 2017)Accelerated Mesenchymal Stem Cells (MSCs) condensation and robust MSC-matrix and MSC-MSC interactions on nano-surfaces may provide critical factors contributing to such events, likely through the orchestrated signal cascades ... -
Analyses of the modulatory effects of antibacterial silver doped calcium phosphate-based ceramic nano-powder on proliferation, survival, and angiogenic capacity of different mammalian cells in vitro
Bostancıoğlu, R. Beklem; Peksen, Ceren; Genç, Hatice; Gürbüz, Mevlüt; Karel, Filiz Bayrakci; Koparal, Ali Savaş; Koparal, Ayşe Tansu (IOP Publishing LTD, 2015)In this study, the antibacterial, cytotoxic, and angiogenic activities of silver doped calcium phosphate-based inorganic powder (ABT or PAG) were systematically investigated. ABT powders containing varying silver content ... -
Angiogenesis Inhibition by A Lichen Compound Olivetoric Acid
Koparal, Ayşe Tansu; Ulus, Gönül; Zeytinoğlu, Melih; Tay, Turgay; Türk, Ayşen Özdemir (Wiley-Blackwell, 2010)Lichens have been used in folk medicine for centuries and are symbiotic organisms of fungi and algae that produce unique secondary metabolites. Olivetoric acid is one of these secondary metabolites. In the present studs ... -
Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid
Koparal, Ayşe Tansu (Walter De Gruyter GMBH, 2015)The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT ... -
The anti-angiogenic potential of (+/-) gossypol in comparison to suramin
Ulus, Gönül; Koparal, Ayşe Tansu; Baysal, Kemal; Yetik Anacak, Günay; Yavaşoğlu, N. Ülkü Karabay (Springer, 2018)Cotton, a staple fiber that grows around the seeds of the cotton plants (Gossypium), is produced throughout the world, and its by products, such as cotton fibers, cotton-seed oil, and cottonseed proteins, have a variety ... -
Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes
Varol, Mehmet; Koparal, Ayşe Tansu; Benkli, Kadriye; Bostancıoğlu, Rakibe Beklem (Bentham Science Publ LTD, 2018)Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. Objective: A ... -
Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil
Bostancıoğlu, R. Beklem; Kürkçüoğlu, Mine; Başer, K. Hüsnü Can; Koparal, Ayşe Tansu (Pergamon-Elsevier Science LTD, 2012)Medicinal plants and culinary herbs with anti-angiogenic and little toxicity properties have gained importance. Non-toxic anti-angiogenic phytochemicals are useful in combating cancer by preventing the formation of new ... -
Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates
Bayulken, Devrim Güzel; Bostancıoğlu, Rakibe Beklem; Koparal, Ayşe Tansu; Tüylü, Berrin; Dağ, Aydan; Benkli, Kadriye (Springer, 2018)Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a ... -
Biocompatibility of designed MicNo-ZnO particles: Cytotoxicity, genotoxicity and phototoxicity in human skin keratinocyte cells
Genç, Hatice; Barutca, Banu; Koparal, Ayşe Tansu; Özogut, Uğurcan; Şahin, Yücel; Suvacı, Ender (Pergamon-Elsevier Science LTD, 2018)Recently, designed platelet shaped micron particles that are composed of nano primary particles, called MicNo (= Micron + naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse ... -
Cryptic fragment ?4 LG4-5 derived from laminin ?4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2
Yamanaka, Hiroaki; Goto, Chie; Tajima, Rie; Koparal, Ayşe Tansu; Kobori, Masato; Ohki, Yuji; Kitagawa, Y. (2008)Cleavage of the extracellular matrix (ECM) by proteolysis unmasks cryptic sites and generates novel fragments with biological activities functionally distinct from those of the intact ECM molecule. The laminin G-like (LG)4-5 ... -
Cryptic fragment alpha 4 LG4-5 derived from laminin alpha 4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2
Yamashita, Hironobu; Goto, Chie; Tajima, Rie; Koparal, Ayşe Tansu; Kobori, Masato; Ohki, Yuji; Kitagawa, Yasuo (Blackwell Publishing, 2008)Cleavage of the extracellular matrix (ECM) by proteolysis unmasks cryptic sites and generates novel fragments with biological activities functionally distinct from those of the intact ECM molecule. The laminin G-like (LG)4-5 ... -
Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp siculum
Rosselli, Sergio; Bruno, Maurizio; Raimondo, Francesco Maria; Spadaro, Vivienne; Varol, Mehmet; Koparal, Ayşe Tansu; Maggio, Antonella (MDPI, 2012)A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been ... -
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
Varol, Mehmet; Benkli, Kadriye; Koparal, Ayşe Tansu; Bostancıoğlu, Rakibe Beklem (Taylor & Francis LTD, 2019)Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ... -
Differential effect of green tea catechins on three endothelial cell clones isolated from rat adipose tissue and on human umbilical vein endothelial cells
Koparal, Ayşe Tansu; Yamaguchi, H; Omae, K; Torii, S; Kitagawa, Y (Springer, 2004)By single colony isolation from the cells in stromal vascular fraction (SVF) dispersed from rat adipose tissues, we isolated three independent clones with different proliferation potential. All clones showed cobblestone-like ... -
Effects of hexagonal boron nitride nanoparticles on antimicrobial and antibiofilm activities, cell viability
Kıvanç, Merih; Barutca, Banu; Koparal, Ayşe Tansu; Göncü, Yapıncak; Bostanci, Selim Hamit; Ay, Nuran (Elsevier Science BV, 2018)The objective of this work was to investigate the antimicrobial and antibiofilm activities of hBN nanoparticles against Streptococcus mutans 3.3, Staphylococcus pasteuri M3, Candida sp. M25 and S. mutans ATTC 25175. Minimum ... -
Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones
Çağır, Ali; Odaci, Burcu; Varol, Mehmet; Akcok, İsmail; Okur, Özgür; Koparal, Ayşe Tansu (Bentham Science Publ LTD, 2017)Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel ... -
Gold(III) compounds-mediated inhibition of lung cancer cell proliferation
Bostancıoğlu, R. Beklem; Kaya, Murat; Koparal, Ayşe Tansu; Benkli, Kadriye (Lippincott Williams & Wilkins, 2016)Research on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for cancer cells and exert ... -
The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line
Kaplan, Ayşe; Benkli, Kadriye; Koparal, Ayşe Tansu (Springer, 2018)Purpose The aim of this study is to detect apoptotic and cytotoxic/antiproliferative effects of a ligand substance and its metal derivatives. The substances were investigated by using an h-ras oncogene transformed rat ... -
In vitro cytotoxic activities of (+)-usnic acid and (-)-usnic acid on V79, A549, and human lymphocyte cells and their non-genotoxicity on human lymphocytes
Koparal, Ayşe Tansu; Tüylü, Berrin; Türk, H. (Taylor & Francis LTD, 2006)This study investigates cytotoxic and genotoxic activities of (+)-Usnic acid and (-)-usnic acid isolated from the lichen Ramalina farinacea and the lichen Cladonia foliacea, respectively. To determine the activities of ... -
In vitro evaluation of combination of EGCG and Erlotinib with classical chemotherapeutics on JAR cells
Telli, Elçin; Genç, Hatice; Tasa, Burcugül Altuğ; Özalp, S. Sinan; Koparal, Ayşe Tansu (Springer, 2017)Gestational Trophoblastic Neoplasia (GTN) is a term used for a group of malignant gynecological tumors including choriocarcinoma. Low-risk neoplasias can be cured using single agents Methotrexate (MTX) and actinomycin-D(ACD), ...