Kurum Yazarı "Kutlu, Hatice Mehtap" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Acrylamide exerts its cytotoxicity in NIH/3T3 fibroblast cells by apoptosis
Şahintürk, Varol; Kacar, Sedat; Vejselova, Djanan; Kutlu, Hatice Mehtap (Sage Publications Inc, 2018)Objective: Acrylamide is a chemical utilized in various industries, and many studies have demonstrated its toxicity. The NIH/3T3 mouse embryonic cell line is the standard cell line of fibroblasts, which have a pivotal role ... -
Acrylamide-derived cytotoxic, anti-proliferative, and apoptotic effects on A549 cells
Kacar, S.; Vejselova, Djanan; Kutlu, Hatice Mehtap; Şahintürk, V. (SAGE Publications LTD, 2018)Background: Acrylamide is a very common compound even reaching up to our daily foods. It has been studied in a wealth of cell lines on which it proved to have various toxic effects. Among these cell lines, human lung ... -
The apoptotic and genomic studies on A549 cell line induced by silver nitrate
Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (SAGE Publications LTD, 2017)Lung cancer is the leading cause of male cancer deaths worldwide. Metal-based anticancer drugs have evolved significantly during the past decades. Recently, silver ions have been investigated for their anticancer effects. ... -
The Apoptotic Effects of Escin in The H-Ras Transformed 5RP7 Cell Line
Güney, G.; Kutlu, Hatice Mehtap; İşcan, A. (Wiley, 2013)Extracts of Aesculus hippocastanum L. (horse chestnut) seed have been used in the treatment of chronic venous insufficiency, edema and hemorrhoids. Most of the beneficial effects of horse chestnut are attributed to its ... -
Biochemial properties of glutathione peroxidase m Gammarus pulex
Kutlu, Hatice Mehtap; Susuz, F (Springer, 2004)… -
A comparative study on the therapeutic effects of Silymarin and Silymarin-Loaded Solid Lipid Nanoparticles on D-GaIN/TNF-alpha-induced Liver Damage in Balb/c Mice
Cengiz, Mustafa; Kutlu, Hatice Mehtap; Burukoğlu, Dilek; Ayhanci, Adnan (Pergamon-Elsevier Science LTD, 2015)Nanostructure-mediated drug delivery is known to have a potential to improve drug bioavailability, apart from fostering release deviation of drug molecules and enabling precision drug targeting. Solid lipid nanoparticles ... -
Cytotoxic, anti-proliferative and apoptotic effects of silver nitrate against H-ras transformed 5RP7
Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (Springer, 2016)Metal based drugs have successfully been used in both the detection and treatment of different disease states. The antibacterial features of metal ion silver are well documented. Most recently, metal ion silver has been ... -
delta-Aminolevulinic acid dehydratase of Haloarcula argentinensis isolated from Tuz Lake in Turkey
Korcan, S. Elif; Mutlu, M. Burçin; Ciğerci, I. Hakkı; Güven, Kıymet; Konuk, Muhsin; Kutlu, Hatice Mehtap (Springer, 2010)The delta-aminolevulinic acid dehydratase (ALAD) enzyme of a novel record for Turkish microbial flora was studied. The isolate I-113 was obtained from Tuz Lake in Turkey and identified as Haloarcula argentinensis. The ALAD ... -
Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver
Kılıç, Gözde Aydoğan; Kutlu, Hatice Mehtap (Pergamon-Elsevier Science LTD, 2010)Metallothionein (MT) is a low-molecular weight sulfur-rich protein that plays role in metal homeostasis/detoxification and radical scavenging. The following study investigated the ability of exogenous MT to protect against ... -
Effects of Lead as an Environmental Pollutant on EROD Enzyme in Gammarus pulex (L.) (Crustacea: Amphipoda)
Kutlu, Hatice Mehtap; Susuz, F. (Springer New York, 2004)[No abstract available] -
Effects of lead on the activity of 6-aminolevulinic acid dehydratase in Gammarus pulex
Kutlu, Hatice Mehtap; Sümer, S (Springer Verlag, 1998)… -
Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines
Çiftçi, Gülsen Akalın; İşcan, Arzu; Kutlu, Hatice Mehtap (Springer, 2015)Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory, antianalgesic, and antipyretic activities. The main active compound of ... -
Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells
Vejselova, Djanan; Kutlu, Hatice Mehtap; Kuş, Gökhan (Springer, 2016)Acid ceramidases are enzymes with a vital role in metabolizing ceramide to sphingosine-1-phosphate that is an antiproliferative metabolite in the ceramide pathway. Inhibition of exogenous ceramides with ceramidase inhibitors ... -
Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
Kaplan, Ayşe; Kutlu, Hatice Mehtap; Çiftçi, Gülsen Akalın (Routledge Journals, Taylor & Francis LTD, 2019)The magnetite nanoparticles are progressively used in a wide range of biological applications. In the present study, we purposed to show apoptosis-inducing ability of Fe3O4 nanopowders on A549 cells. In addition, the toxic ... -
Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2
Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi; Kutlu, Hatice Mehtap (Springer, 2015)Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential ... -
Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid.
Magnetic nanoparticles show great promise for use as tools in a wide variety of biomedical applications. The purpose of this study was to investigate the potential effects of methacrylamido-folic acid (Ma-Fol)-modified ... -
Investigation of photosensitively bioconjugated targeted quantum dots for the labeling of Cu/Zn superoxide dismutase in fixed cells and tissue sections
Say, Rıdvan; Aydoğan-Kılıc, G.; Özcan, Ayça Atılır; Hür, Deniz; Yılmaz, Filiz; Kutlu, Hatice Mehtap; Ersöz, Arzu (Springer, 2011)This study presents the development of targeted and antibody cross-linked QDs and explores whether these bioconjugates could specifically and effectively label Cu/Zn superoxide dismutase (SOD1) on fixed cells and tissues. ...