PubMed İndeksli Yayınlar Koleksiyonu by Institution Author "Sivas, Hülya"
Now showing items 1-16 of 16
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Biological assays on the effects of Acra3 peptide from Turkish scorpion Androctonus crassicauda venom on a mouse brain tumor cell line (BC3H1) and production of specific monoclonal antibodies
Çalışkan, Figen; Ergene, Emel; Sögüt, İbrahim; Hatipoğlu, İbrahim; Basalp, Aynur; Sivas, Hülya; Kanbak, Güngör (Pergamon-Elsevier Science LTD, 2013)Constitutes of the venom scorpion are a rich source of low molecular mass peptides which are toxic to various organisms, including man. Androctonus crassicauda is one of the scorpions from the Southeastern Anatolia of ... -
Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum zeylanicum Blume (Lauraceae)
Ünlü, Mehmet; Ergene, Emel; Ünlü, Gülhan Vardar; Sivas, Hülya; Vural, Nilüfer (Pergamon-Elsevier Science LTD, 2010)The essential oil from the bark of Cinnamomum zeylanicum Blume was analyzed by GC-MS and bioassays were carried out. Nine constituents representing 99.24% of the oil were identified by GC-MS. The major compounds in the oil ... -
Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells
Kuete, Victor; Omosa, Leonidah K.; Tala, Viviane R. Sipowo; Midiwo, Jacob O.; Mbaveng, Armelle T.; Swaleh, Sauda; Sivas, Hülya (Bmc, 2016)Background: Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases. Methods: This study was designed to investigate the cytotoxicity of ... -
Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells
Kuete, Victor; Ngnintedo, Dominique; Fotso, Ghislain W.; Karaosmanoğlu, Oğuzhan; Ngadjui, Bonaventure T.; Keumedjio, Felix; Sivas, Hülya (Bmc, 2018)Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ... -
Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells
Kuete, Victor; Fokou, Fabrice W.; Karaosmanoğlu, Oğuzhan; Beng, Veronique P.; Sivas, Hülya (Bmc, 2017)Background: Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system. Methods: In this study, the cytotoxicity of the methanol extract ... -
Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro
Sivas, Hülya; Seller, Zerrin; Tüylü, Berrin; Türk, A. O.; Barutca, B. (Wiley, 2008)Naturally occurring compounds can have protective effects towards mutagens and carcinogens as shown by numerous studies. In the present study, the genotoxic/antigenotoxic activities of the extract from lichen Cetraria ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
Seller, Zerrin; Hatipoğlu, İbrahim; Sivas, Hülya; Ergene, Emel; Çiftçi, Gülsen Akalın (Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
The effects of n-ras oncogene expression on PDGF-BB stimulated responses in cultured mouse myoblasts
Sivas, Hülya; Griffiths, S. L.; Dawson, A. P.; Gibson, I. (1995)The role of the ras oncogene in the signalling pathway triggered by platelet-derived growth factor BB (PDGF-BB) has been investigated in a cell line which normally differentiates into myotubes. Following the activation of ... -
Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells
Karaosmanoğlu, Oğuzhan; Banerjee, Sreeparna; Sivas, Hülya (Springer, 2018)Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal transition (EMT) has long been considered as a crucial step for metastasis initiation. It ... -
Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene
Sivas, Hülya; Seller, Zerrin; Başer, K. Hüsnü Can (Urban & Fischer Verlag, 2003)Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional ... -
Investigation of genotoxic effects of paraben in cultured human lymphocytes
Bayulken, Devrim Güzel; Tüylü, Berrin; Sinan, Handan; Sivas, Hülya (Taylor & Francis LTD, 2019)Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the ... -
Mutagenicity assay in Salmonella for thirteen 2-substituted-1H-phenanthro (9,10-d) imidazoles
Sivas, Hülya; Ergene, E; Tüylü, Berrin (Taylor & Francis LTD, 2003)Some 2-substituted-1H-phenanthro [9,10-d] imidazole compounds synthesized as a predrugs were tested in mutagenicity assays in Salmonella strains TA97, TA98, and TA100 using a plate incorporation assay both with and without ... -
Novel Nanoimaging Approach: Antibodious Polymeric Nanolabel for Intracellular Alpha-Fetoprotein Targeted Monitoring
Ünlüer, Özlem Biçen; Ersöz, Arzu; Say, Rıdvan; Tomsuk, Özlem; Sivas, Hülya (Wiley-Blackwell, 2013)This study describes preparation and use of novel labeled and antibodious polymeric nanolabels (anti-alpha fetoprotein cross-linked nanolabels) as an immunogenic and semisynthetic nanolabel with potential prognostic and ... -
Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells
Demiroğlu-Zergeroğlu, Asuman; Ergene, Emel; Ayvali, Nurettin; Kuete, Victor; Sivas, Hülya (Bmc, 2016)Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination ... -
Synthesis and characterization of a new macrocyclic ligand and its copper (II), cadmium (II), and lead (II) complexes: Genotoxic activity of these complexes in cultured human lymphocytes
Beynek, Nesrin; Uluçam, Gühergül; Tüylü, Berrin; Sivas, Hülya; Benkli, Kadriye (Taylor & Francis Inc, 2007)A new macrocyclic ligand 1,1'-bis(bis-(6,6'-oxymethylenyl-2,2'-bipyridine) binaphthyl, (L), and its complexes CuL(ClO4)(2), CuL(NO3)(2,) 3H(2)O, CdL(ClO4)(2), and PbL(ClO4)(2) have been synthesized and characterized on the ... -
Testing wound-healing activity in T15 fibroblast cultures: A morphometric analysis
Korkmaz, S; Sivas, Hülya; Zeytinoğlu, Melih; Aydın, Süleyman; Öztürk, Yusuf; Başer, K. Hüsnü Can (Frame, 2000)The purpose was to evaluate the use of mouse T15 fibroblast cell cultures for the investigation of wound-healing activity. In order to investigate their mechanisms of action, the effects of drugs with wound-healing activities ...