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dc.contributor.authorKarakaya, Songul
dc.contributor.authorBingol, Zeynebe
dc.contributor.authorKoca, Mehmet
dc.contributor.authorDemirci, Betul
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorBaser, K. Husnu Can
dc.date.accessioned2020-07-09T20:58:41Z
dc.date.available2020-07-09T20:58:41Z
dc.date.issued2020
dc.identifier.issn1041-2905
dc.identifier.issn2163-8152
dc.identifier.urihttps://doi.org/10.1080/10412905.2020.1746415
dc.identifier.urihttps://hdl.handle.net/11421/23967
dc.descriptionGulcin, ilhami/0000-0001-5993-1668; KARAKAYA, Songul/0000-0002-3268-721Xen_US
dc.descriptionWOS: 000524099800001en_US
dc.description.abstractThe oxidant, cholinesterase, and carbonic anhydrase inhibitions of essential oils and their major compounds of Leiotulus dasyanthus and molecular docking studies of alpha-pinene and (TM)-3-carene were evaluated in this study. Phenolic constituents and antioxidant activity of samples were determined by Folin-Ciocalteu's, DPPH, and TBA processes. Cholinesterase inhibition effect was evaluated through Ellman's method. GC-FID and GC/MS were used for analysing of essential oils. the root oil got the highest total phenolic content (898.87 mg/g). the utmost activity was shown flower oil (29.31 mu g/mL) in the DPPH test. the root oil indicated considerable inhibition towards acetylcholinesterase (21.92%) and butyrylcholinesterase (91.33%) enzymes, respectively. alpha-pinene and delta-3-carene indicated high acetylcholinesterase inhibitory activity (66.44 and 48.71%, respectively). Cytosolic hCA I and II isoenzymes were influentially inhibited by flower and aerial part oils with 1.694 and 1.677 mu M IC50 values, respectively. 1-Dodecanol (7.8%); beta-pinene (63.3%), alpha-pinene (20.5%); octyl acetate (14.7%); hexyl octanoate (55.1%) were characterized as principle compounds of aerial parts, roots, flowers, and fruits respectively.en_US
dc.description.sponsorshipAtaturk UniversityAtaturk University [TAB-2018-6432]en_US
dc.description.sponsorshipThis work was assisted by the Scientific Research Projects of Ataturk University (TAB-2018-6432).Scientific Research Projects of Ataturk University (TAB-2018-6432).en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.isversionof10.1080/10412905.2020.1746415en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticholinesteraseen_US
dc.subjectantioxidanten_US
dc.subjectcarbonic anhydraseen_US
dc.subjectleiotulusen_US
dc.subject(TM)-3-careneen_US
dc.subjectpineneen_US
dc.titleScreening of non-alkaloid acetylcholinesterase and carbonic anhydrase isoenzymes inhibitors of Leiotulus dasyanthus (K. Koch) Pimenov & Ostr. (Apiaceae)en_US
dc.typearticleen_US
dc.relation.journalJournal of Essential Oil Researchen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.startpage227en_US
dc.identifier.endpage241en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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