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dc.contributor.authorAcar Cevik, Ulviye
dc.contributor.authorOsmaniye, Derya
dc.contributor.authorSaglik, Begum N.
dc.contributor.authorLevent, Serkan
dc.contributor.authorK. Cavusoglu, Betul
dc.contributor.authorKaraduman, Abdullah B.
dc.contributor.authorTuran, Gulhan
dc.date.accessioned2020-07-09T20:58:44Z
dc.date.available2020-07-09T20:58:44Z
dc.date.issued2020
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.urihttps://doi.org/10.1002/jhet.3942
dc.identifier.urihttps://hdl.handle.net/11421/23997
dc.descriptionKaraduman, Abdullah Burak/0000-0002-0434-1334en_US
dc.descriptionWOS: 000515472200001en_US
dc.description.abstractMonoamine oxidases (MAO) are enzymes that catalyze the oxidative deamination of monoamines such as dopamine, noradrenaline, adrenaline, and serotonin. Recent studies have shown that numerous benzothiazole derivatives exhibit hMAO inhibitory activity in the micromolar concentration range. in this study, a novel series of benzothiazole-thiadiazole (5a-5l) was synthesized and characterized their chemical structures by H-1-NMR, C-13-NMR, and Mass spectroscopy. These compounds were evaluated as inhibitors for types A and B MAO enzymes. Compounds 5f and 5l were the most active derivatives in the series with an IC50 values of 0.107 +/- 0.003 and 0.128 +/- 0.004, respectively. Furthermore, cytotoxicity of compounds 5f and 5l were investigated and found as non-cytotoxic.en_US
dc.description.sponsorshipAnadolu University BAP ProjectAnadolu University [1805S191]en_US
dc.description.sponsorshipThis study was carried out with the support of Anadolu University BAP Project No: 1805S191.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jhet.3942en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSynthesis of new benzothiazole derivatives bearing thiadiazole as monoamine oxidase inhibitorsen_US
dc.typearticleen_US
dc.relation.journalJournal of Heterocyclic Chemistryen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume57en_US
dc.identifier.issue5en_US
dc.identifier.startpage2225en_US
dc.identifier.endpage2233en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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