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dc.contributor.authorDurgun, Mustafa
dc.contributor.authorTurkes, Cuneyt
dc.contributor.authorIsik, Mesut
dc.contributor.authorDemir, Yeliz
dc.contributor.authorSakli, Ali
dc.contributor.authorKuru, Ali
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2020-07-09T20:58:46Z
dc.date.available2020-07-09T20:58:46Z
dc.date.issued2020
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.urihttps://doi.org/10.1080/14756366.2020.1746784
dc.identifier.urihttps://hdl.handle.net/11421/24023
dc.descriptionakocak, suleyman/0000-0003-4506-5265; Durgun, Mustafa/0000-0003-3012-7582en_US
dc.descriptionWOS: 000523492900001en_US
dc.descriptionPubMed: 32249705en_US
dc.description.abstractSulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, C-13 NMR, H-1 NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Their antioxidant activity was determined using different bioanalytical assays such as radical scavenging tests with ABTS(center dot+), and DPPH center dot+ as well as metal-reducing abilities with CUPRAC, and FRAP assays. All compounds showed satisfactory enzyme inhibitory potency in nanomolar concentrations against AChE and CA isoforms with K-I values ranging from 10.14 +/- 0.03 to 100.58 +/- 1.90 nM. Amine group containing derivatives showed high metal reduction activity and about 70% ABTS radical scavenging activity. Due to their antioxidant activity and AChE inhibition, these novel compounds may be considered as leads for investigations in neurodegenerative diseases.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi ArabiaDeanship of Scientific Research at King Saud University [RSP-2019/1]en_US
dc.description.sponsorshipThis work was in part also funded by the Researchers Supporting Project No. (RSP-2019/1) King Saud University, Riyadh, Saudi Arabia.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.isversionof10.1080/14756366.2020.1746784en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectsynthesisen_US
dc.subjectsulphonamideen_US
dc.subjectmolecular dockingen_US
dc.titleSynthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff basesen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume35en_US
dc.identifier.issue1en_US
dc.identifier.startpage950en_US
dc.identifier.endpage962en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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