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dc.contributor.authorSenel, Behiye
dc.contributor.authorOrturk, A. Alper
dc.date.accessioned2020-07-09T20:58:58Z
dc.date.available2020-07-09T20:58:58Z
dc.date.issued2019
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.urihttps://doi.org/10.1080/03639045.2019.1665061
dc.identifier.urihttps://hdl.handle.net/11421/24120
dc.descriptionOzturk, A. Alper/0000-0001-9596-0538en_US
dc.descriptionWOS: 000487113100001en_US
dc.descriptionPubMed: 31491363en_US
dc.description.abstractObjective: in this study, we aimed to develop a candidate modifited polymeric nanoparticle (NP) system that will kill cancer cells by facilitated to apoptosis and also reduce pain. Methods: Chitosan-modified PLGA NPs were prepared using an nanoprecipitation technique. the NPs were loaded with flurbiprofen and decorated with folic acid. STAT3-siRNA was adsorbed to these polymeric NPs using antisense technology. Results: the NPs were small in size (176.9-220.3 nm) with positive zeta potential (+14.1 mV to +27.2 mV). They had high loading capacity and prolonged release properties over 144 hours. Cytotoxicity studies performed with siRNA showed effective electrostatic interaction due to the positively charged NPs. Folic acid facilitated entry into cancer cells and helped to kill them. Conclusion: the formulation we developed is a potential carrier system for both treatment of cancer and prevention of pain, especially for metastatic cancers.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.isversionof10.1080/03639045.2019.1665061en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSTAT3 siRNAen_US
dc.subjectflurbiprofenen_US
dc.subjectPLGA nanoparticlesen_US
dc.subjectfolic aciden_US
dc.subjectchitosanen_US
dc.titleNew approaches to tumor therapy with siRNA-decorated and chitosan-modified PLGA nanoparticlesen_US
dc.typearticleen_US
dc.relation.journalDrug Development and Industrial Pharmacyen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.identifier.volume45en_US
dc.identifier.issue11en_US
dc.identifier.startpage1835en_US
dc.identifier.endpage1848en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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