Yazar "Kabadere, Selda" için Makale Koleksiyonu listeleme
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Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro
Kuş, Gökhan; Özkurt, Mete; Kabadere, Selda; Erkasap, Nilüfer; Göğer, Gamze; Demirci, Fatih (Comenius University, 2018)OBJECTIVES: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma, T98; prostate, LnCaP) as well as mouse embryonic fi broblast cell lines (3T3), and ... -
Comparing the Role of Silymarin on Survival Rate of Rat Glioma With Primary Mixed Rat Glia Cells in Vitro
Gezgin, Duygu; Kabadere, Selda; Uyar, Ruhi; Kuş, Gökhan (Parlar Scientific Publications (PSP), 2013)Phytochemicals, nutraceuticals and herbal products, such as silymarin, have gained ever growing popularity and are valued for their ability to defend against almost all types of disease. Primarily known as hepatoprotective ... -
Cytotoxic and Apoptotic Functions of Licofelone on Rat Glioma Cells
Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi; Kabadere, Selda (Akademiai Kiado Zrt, 2013)Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase and lipoxygenase pathways that take role in arachidonic acid ... -
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line
Başpınar, Mustafa Serhat; Özyurt, Rumeysa; Kuş, Gökhan; Kutlay, Özden; Özkurt, Mete; Erkasap, Nilüfer; Kabadere, Selda (Comenius University, 2017)OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. MATERIALS AND METHODS: The cell lines were treated ... -
Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2
Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi; Kutlu, Hatice Mehtap (Springer, 2015)Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential ... -
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis
Kabadere, Selda; Kuş, Gökhan; Uyar, Ruhi; Öztopçu-Vatan, Pınar (Informa Healthcare, 2014)Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways ... -
Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines
Ertekin, Rıfat; Özkurt, Mete; Kuş, Gökhan; Kabadere, Selda (Zoological Soc Pakistan, 2019)Prostate cancer is a common type of cancer. Contemporary treatment modalities require that new, effective methods or chemicals should be developed. Tolfenamic acid (TA) is a nonsteroidal anti-inflammatory medicine stimulating ...