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Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2
(Springer, 2015)
Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential ...
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line
(Comenius University, 2017)
OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. MATERIALS AND METHODS: The cell lines were treated ...