Ara
Toplam kayıt 14, listelenen: 1-10
Inhibitory Effects of Usnic and Carnosic Acid on Some Metabolic Enzymes: An in vitro Study
(Bentham Science Publ LTD, 2019)
Background: Natural products arc produced via primary and secondary metabolism in different organisms. The compounds obtained via secondary metabolism are not essential for the survival of the organism, but they can have ...
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, alpha-amylase and alpha-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
(Elsevier Science BV, 2018)
Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ...
Phytase from Weissella halotolerans: purification, partial characterisation and the effect of some metals
(Taylor & Francis Inc, 2017)
In the study, phytase was purified in three simple steps comprising ammonium sulphate precipitation, anion exchange and gel filtration chromatography from Weissella halotolerans. The enzyme was obtained with a specific ...
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)
The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically ...
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
(Elsevier, 2019)
Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ...
Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
(Wiley, 2017)
Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, ...
Evaluation of chalcones as inhibitors of glutathione S-transferase
(Wiley, 2018)
Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ...
The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study
(Taylor & Francis LTD, 2019)
Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. ...
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
(Wiley, 2018)
Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ...
Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)
Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ...