Determination of amoxicillin by flow injection analysis using UV-detection, potentiometry, and conductometry in pharmaceutical preparations
Abstract
A method for direct determination of amoxicillin in pharmaceuticals using flow injection analysis (FIA) with UV detection adjusted at 228 nm, along with potentiometer and condoptometric methods are described. The best carrier solvent system consisted of an aqueous solution of methanol (10% v/v) with pH 9 pumped at a flow rate of 1 mL . min(-1). The limit of detection (LOD) and quantification (LOQ) for FIA was calculated to be 3.3 x 10(-7) M (S/N = 3) and 1.0 X 10(-7) M (S/ N = 10), respectively. Two pharmaceutical formulations containing amoxicillin were studied. In the analysis of the tablets, the RSD values were found to be 1.36 and 1.21 and 1.18 (for AMOKLAVIN (R)), 1.10 1.16 and 1.14 (for REMOXIL (R)) for FIA, potentiometer, and conduct metric methods, respectively. The proposed methods were applied to the pharmaceutical tablets and good results were obtained. These proposed methods are simple, fast, accurate, precise, and cost effective for the routine determination of amoxicillin in pharmaceutical preparations.
Source
Journal of Liquid Chromatography & Related TechnologiesVolume
30Issue
9.AraCollections
- Makale Koleksiyonu [115]
- Scopus İndeksli Yayınlar Koleksiyonu [8325]
- WoS İndeksli Yayınlar Koleksiyonu [7605]
Related items
Showing items related by title, author, creator and subject.
-
A risk analysis model for mining accidents using a fuzzy approach based on fault tree analysis
Yaslı, Fatma; Bolat, Bersam (Emerald Group Publishing LTD, 2018)Purpose Risk analysis is a critical investigation field for many sectors and organizations to maintain the information management reliable. Since mining is one of the riskiest sectors for both workers and management, ... -
Extension of the Capon's spectral estimator to time-frequency analysis and to the analysis of polynomial-phase signals
Özgen, MT (Elsevier Science BV, 2003)Incorporation of the linear time-varying filter and, its Zadeh's generalized transfer function concepts to the derivation of the Capon's minimum-variance spectral estimator leads to a new, bilinear, cross-term suppressed ... -
Determination of carbamazapine by flow-injection analysis: Its application to tablet analysis and dissolution studies
Çomoğlu, T.; Gönül, N.; Şener, E.; Dal, Arın Gül; Tunçel, Muzaffer (Taylor & Francis Inc, 2006)Flow injection analysis (FIA) of carbamazepine (CBZ) and its relevant application to the conventional CBZ tablets, e. g., content uniformity test and tablet dissolution, is described in this study. An aqueous solution of ...