Synthesis and antimicrobial activity of benzimidazole-based acetamide derivatives
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info:eu-repo/semantics/closedAccessDate
2015Author
Altıntop, Mehlika DilekAbu Mohsen, Usama
Özkay, Yusuf
Demirel, Rasime
Kaplancıklı, Zafer Asım
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In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa. These compounds and streptomycin exhibited the same level of antibacterial activity with a MIC value of 125 µg/mL. Compounds 2p, 2s, 2t and 2u were the most potent antifungal derivatives against Candida krusei with a MIC value of 125 µg/mL when compared with ketoconazole (MIC= 62.5 µg/mL). Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 µg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 µg/mL
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Turkish Journal of Pharmaceutical SciencesVolume
12Issue
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