Synthesis and antimicrobial activity of benzimidazole-based acetamide derivatives
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Erişim
info:eu-repo/semantics/closedAccessTarih
2015Yazar
Altıntop, Mehlika DilekAbu Mohsen, Usama
Özkay, Yusuf
Demirel, Rasime
Kaplancıklı, Zafer Asım
Üst veri
Tüm öğe kaydını gösterÖzet
In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa. These compounds and streptomycin exhibited the same level of antibacterial activity with a MIC value of 125 µg/mL. Compounds 2p, 2s, 2t and 2u were the most potent antifungal derivatives against Candida krusei with a MIC value of 125 µg/mL when compared with ketoconazole (MIC= 62.5 µg/mL). Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 µg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 µg/mL
Kaynak
Turkish Journal of Pharmaceutical SciencesCilt
12Sayı
1Bağlantı
https://hdl.handle.net/11421/13811Koleksiyonlar
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