Synthesis of platinum(II) complexes of 1-ARYL-3-(benzimidazole-2-YL)-pyrazole-4-ketoximes and studies on their cytotoxic effects

Abstract

Bu çahsmada bazı l-Aril-3-(benzimidazol-2-il)-pirazol-4-ketoksim’lerin Pt(II) kompleksleri sentezlenmiştir. Bileşiklerin yapılan IR, 'H-NMR, Kittle ve elementel analiz He aydınlatılmistır. Pt(II) komplekslerinin sitotoksik etkileri araştmlmistır. Hücresel cevaplar, normal sican embriyo fibroblastı F2408 ve aktif sigan embriyo fibroblastında, MTT metodu kullamlarak ölqulmustür.

In this research, synthesis of some complexes in the presence of Pt(II) were studied. The structure of the compounds were elucidated by IR, 'H-NMR, Mass and Elemental Analyses. The cytotoxicity of Pt-complex was evaluated. The cellular responses through MTT method were measured in normal rat embryo fibroblast line F2408 and H-ras active-rat embryo fibroblast line 5RP7.