Comparison of the bioavailability of oral and rectal forms of diphenylhydantoin sodium

Abstract

The bioavailabilities of single 100-mg oral and rectal doses of diphenylhydantoin sodium were studied in five healthy volunteers. The rectal form used was prepared at laboratory conditions and the oral form was a commercial preparation. Blood samples were analysed over a 72-hr period. Evaluation of the AUC, tmax and Cmax values have shown that the total absorption after the two routes of administration was the same while the Cmax and tmax differed