• Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones 

  Bilginer, Sinan; Gul, Halise Inci; Erdal, Feyza Sena; Sakagami, Hiroshi; Levent, Serkan; Gulcin, Ilhami; Supuran, Claudiu T. (Taylor & Francis Ltd, 2019)

  In this study, new chalcone compounds having the chemical structure of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones (1?8) were synthesised and were characterised by H-1-NMR, C-13?-NMR, and HRMS spectra. Cytotoxic and carbonic ...

• Plant- and Nutraceutical-based Approach for the Management of Diabetes and its Neurological Complications: A Narrative Review 

  Ozturk, Yusuf; Ozturk, Nilgun (Bentham Science Publ Ltd, 2019)

  Diabetes is an important metabolic disease affecting many organs and systems in the body. the nervous system is one of the body systems affected by diabetes and neuropathic complications are troublesome in diabetic patients ...

• Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells 

  Kuete, Victor; Omosa, Leonidah K.; Midiwo, Jacob O.; Karaosmanoglu, Oguzhan; Sivas, Hulya (Elsevier, 2019)

  Background: Cancer constitutes a major hurdle worldwide and its treatment mainly relies on chemotherapy. Objectives: the present study was designed to evaluate the cytotoxicity of eleven naturally occurring compounds ...

• Chemical composition and antioxidant, cytotoxic, and insecticidal potential of Valeriana alliariifolia in Turkey 

  Sen-Utsukarci, Burcu; Taskin, Turgut; Goger, Fatih; Tabanca, Nurhayat; Estep, Alden S.; Kessler, Sonja M.; Mat, Afife (Inst Medical Research & Occupational Health, 2019)

  Valeriana is a common plant species used for various healing purposes in folk medicine since antiquity. This study investigates the phytochemical profile, antioxidant, cytotoxic, and insecticidal activity of Valeriana ...

• Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives 

  Ertas, Merve; Sahin, Zafer; Bulbul, Emre F.; Bender, Ceysu; Biltekin, Sevde N.; Berk, Barkin; Demirayak, Seref (Wiley-V C H Verlag Gmbh, 2019)

  The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. in addition, thiosemicarbazones are among the most potent and ...

• New approaches to tumor therapy with siRNA-decorated and chitosan-modified PLGA nanoparticles 

  Senel, Behiye; Orturk, A. Alper (Taylor & Francis Ltd, 2019)

  Objective: in this study, we aimed to develop a candidate modifited polymeric nanoparticle (NP) system that will kill cancer cells by facilitated to apoptosis and also reduce pain. Methods: Chitosan-modified PLGA NPs were ...

• Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects 

  Ozturk, A. Alper; Yenilmez, Evrim; Ozarda, Mustafa Gueclue (Mdpi, 2019)

  Clarithromycin (CLR) is a member of the macrolide antibiotic group. CLR has low systemic oral bioavailability and is a drug of class II of the Biopharmaceutical Classification System. in many studies, using nanoparticles ...

• Active Video Games versus Traditional Exercises: Energy Expenditure and Blood Lactate Responses 

  Cakir-Atabek, Hayriye; Aygun, Cihan; Dokumaci, Bircan (Routledge Journals, Taylor & Francis Ltd, 2020)

  Purpose: the current study aimed to investigate the exercise intensity and exercise characteristics of active video games (AVGs) by measuring various physiological responses, and to test whether AVGs can be used in components ...

• Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements 

  Aggarwal, Vaishali; Tuli, Hardeep Singh; Varol, Aysegul; Thakral, Falak; Yerer, Mukerrem Betul; Sak, Katrin; Sethi, Gautam (Mdpi, 2019)

  Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration ...

• AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress 

  Isik, Mesut; Beydemir, Sukru (Taylor & Francis Ltd, 9999)

  Oxidative metabolic reactions and their by products have played a role in coronary artery disease (CAD) and Alzheimer's disease (AD) pathogenesis. This study was carried out on 28 patients with AD, 21 patients with CAD, ...

• Increasing Verbal Interaction in Children with Autism Spectrum Disorders Using Audio Script Procedure (vol 49, pg 4847, 2019) 

  Topuz, Cetin; Ulke-Kurkcuoglu, Burcu (Springer/Plenum Publishers, 2019)

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• Comment on: "clinical relevance of insulin-like growth factor-1 to cardiovascular risk markers" 

  Yildirim, Ozge Turgay; Yildirim, Selim (Taylor & Francis Ltd, 2020)

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• Antiprotozoal Activity of Turkish Origanum onites Essential Oil and Its Components 

  Tasdemir, Deniz; Kaiser, Marcel; Demirci, Betuel; Demirci, Fatih; Baser, K. Huesnue Can (Mdpi, 2019)

  Essential oil of Origanum species is well known for antimicrobial activity, but only a few have been evaluated in narrow spectrum antiprotozoal assays. Herein, we assessed the antiprotozoal potential of Turkish Origanum ...

• Identification of non-alkaloid natural compounds of Angelica purpurascens (Ave-Lall.) Gilli. (Apiaceae) with cholinesterase and carbonic anhydrase inhibition potential 

  Karakaya, Songul; Bingol, Zeynebe; Koca, Mehmet; Dagoglu, Sena; Pinar, Nur Munevver; Demirci, Betul; Sytar, Oksana (Elsevier, 2020)

  In current study is done antioxidant, anticholinesterase, and carbonic anhydrase isoenzymes I and II inhibition assays, screening of biological active compounds and electronic microscopy analysis of secretory canals of ...

• Impact of epilepsy on language and discourse: Two self-limited focal epileptic syndromes of childhood 

  Savas, Merve; Tuncer, Aylin Muge; Cokar, Ayse Ozlem; Demirbilek, Ahmet Veysi; Tuzun, Erdem (Academic Press Inc Elsevier Science, 2020)

  Self-limited focal epilepsy with centro-temporal spikes, also known as Rolandic epilepsy (RE), is a well-established focal epilepsy of childhood, characterized with language impairment. To investigate the relationship ...

• The nicotinic modulation of pain 

  Bektas, Nurcan; Nemutlu, Dilara; Cam, Mevcude; Okcay, Yagmur; Eken, Hazal; Arslan, Rana (Univ Karachi, 2020)

  Pain is a physiological unpleasant sensation that associated with actual or potential tissue damage and affects the major part of human population. Numerous modulatory system control pain through a complex process. the ...

• Evaluation of wound healing effect of chitosan-based gel formulation containing vitexin 

  Bektas, Nurcan; Senel, Behiye; Yenilmez, Evrim; Ozatik, Orhan; Arslan, Rana (Elsevier, 2020)

  Acute or chronic wounds are one of the most common health problems worldwide and medicinal drugs or traditional remedies are often used in wound healing. Further studies regarding wound treatment are rapidly continuing. ...

• Submissive Behavior and Cyber Bullying: A Study on the Mediator Roles of Cyber Victimization and Moral Disengagement 

  Eraslan-Capan, Bahtiyar; Bakioglu, Fuad (Ubiquity Press Ltd, 2020)

  In order to prevent cyberbullying and cyber-victim behaviors that are very common among adolescents, it is important to investigate the factors that underlie these behaviors. the purpose of the present study was to examine ...

• The effect of R547, a cyclin-dependent kinase inhibitor, on hepatocellular carcinoma cell death 

  Hacioglu, Betul; Kus, Gokhan; Kutlu, Hatice Mehtap; Kabadere, Selda (Tubitak Scientific & Technical Research Council Turkey, 2020)

  Hepatocellular carcinoma (HCC) is the third main cause of cancer-related death. Cyclin-dependent kinases (CDKs) and their cyclin partners regulate the cell cycle. Since inhibition of CDKs gives some guiding ideas for cancer ...

• Therapeutic Potentials of Inhibition of Jumonji C Domain - containing Demethylases in Acute Myeloid Leukemia 

  Koca, Duygu; Hastar, Nurcan; Engur, Selin; Kiraz, Yagmur; Ulu, Gizem Tugce; Cekdemir, Demet; Baran, Yusuf (Galenos Yayincilik, 2020)

  Objective: Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene ...

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