Ara
Toplam kayıt 43, listelenen: 1-10
Design, synthesis and in vitro COX inhibitory profiles of a new series of tetrazole-based hydrazones
(Anadolu Üniversitesi, 2022)
Inhibition of cyclooxygenases (COXs), by selective and nonselective inhibitors, is a favorable approach for pharmacologic intervention in a variety of disorders such as cancer. For this purpose, a new class of tetrazole-hydrazone ...
Synthesis and characterization of new piperazinedithiocarbamate compounds as potent MAO-A inhibitors
(Anadolu Üniversitesi, 2022)
Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this ...
High-density lipoprotein: Quality is more important than quantity!
(Anadolu Üniversitesi, 2022)
High density lipoproteins (HDLs) are complex lipid carriers which replace their own structures and functions according to different conditions including healthy or pathological status. HDL has substantial roles in reverse ...
Chaerophyllum libanoticum Boiss. Et Kotschy: The fruit essential oil, composition, skin-whitening and antioxidant activities
(Anadolu Üniversitesi, 2022)
This study was aimed to evaluate the essential oil composition of Chaerophyllum libanoticum fruits and its potential uses in the cosmetic industry. The essential oil was analyzed by Gas Chromatography (GC) and Gas ...
Synthesis and in silico evaluation of some new 2,4-disubstituted thiazole derivatives
(Anadolu Üniversitesi, 2022)
The synthesis and anti-proliferative activity investigation of methyl 3/4-[[4-(2-substituted thiazol-4-yl)phenyl]amino]-3-oxopropanoate/(4-oxobutanoate) (3a-h) derivatives were aimed in this work. The synthesis of the new ...
Oral medicine administration errors in a patient with an enteral feeding tube
(Anadolu Üniversitesi, 2023)
Proper nutrition is vital for all patients with an expected lifespan. It is strongly recommended that patients whose oral intake is impaired or suspected to be impaired should be provided nutritional support. Concurrent ...
A new HPLC method for selexipag analysis in pharmaceutical formulation and bulk form
(Anadolu Üniversitesi, 2023)
Selexipag is a new non-prostanoid prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Selexipag is a long-acting IP receptor agonist with a shorter half-life than all other licensed drugs targeting ...
Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new
(Anadolu Üniversitesi, 2023)
Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the ...
Screening of new morpholine dithiocarbamate derivatives bearing benzimidazole moiety for anticholinesterase potential
(Anadolu Üniversitesi, 2023)
Alzheimer’s disease (AD) is basically associated with disturbances of cholinesterase metabolism which result in acetylcholine deficiency. Target of acetylcholinesterase (AChE) inhibitors used in symptomatic therapy of ...
Etiopathogenesis of depression and experimental depression models used in preclinical studies
(Anadolu Üniversitesi, 2023)
Depression is the most frequent psychiatric illness among mood disorders, affecting approximately 10% of adults. Especially recurrent and moderate/severe depression can become a serious public health problem by impairing ...