Yazar "Çiftçi, Gülsen Akalın" için listeleme
-
Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines
Çiftçi, Gülsen Akalın; İşcan, Arzu; Kutlu, Hatice Mehtap (Springer, 2015)Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory, antianalgesic, and antipyretic activities. The main active compound of ... -
Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
Kaplan, Ayşe; Kutlu, Hatice Mehtap; Çiftçi, Gülsen Akalın (Routledge Journals, Taylor & Francis LTD, 2019)The magnetite nanoparticles are progressively used in a wide range of biological applications. In the present study, we purposed to show apoptosis-inducing ability of Fe3O4 nanopowders on A549 cells. In addition, the toxic ... -
In vitro effects of ?-tocopherol and ascorbic acid on antioxidant characteristics of HDL [?-Tokoferol ve askorbik asitin HDL'nin antioksidan özelligi üzerine in vitro etkileri]
Çiftçi, Gülsen Akalın; Erdoğan, I.; Alataş, O. (2011)phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and antiinflammatory properties are as important as its cholesterol efflux function on inhibition ... -
In vitro effects of alpha-tocopherol and ascorbic acid on antioxidant characteristics of HDL
Çiftçi, Gülsen Akalın; Erdoğan, İpek; Alataş, Özkan (Turkish Biochem Soc, 2011)Aim: High density lipoprotein (HDL) retards accumulation of proinflammatuar oxidized phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and ... -
Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım (Springer Birkhauser, 2014)Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung ... -
The LC/ESI-MSMS Profiles and Biological Potentials of Vitex agnus castus Extracts
Ağalar, Hale Gamze; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Göğer, Fatih; Kırımer, Neşe (Natural Products Inc, 2016)The chemical profile, cytotoxic and apoptotic effect, and antioxidant activity were determined of ethanolic extracts of Vitex agnus-castus L. (chaste tree). Ripened fruits and fruitless aerial parts were extracted with ... -
Management of Inflammatory State in Hypercholesterolemic Patients With Atorvastatin Treatment
Alataş, Özkan; Akalın, Ayşen; Çiftçi, Gülsen Akalın; Erdoğan, I. (Birkhauser Verlag Ag, 2011)… -
Melatonin induces antiproliferative activity through modulation of apoptotic pathway in H-ras oncogene transformed 5RP7 cells
Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (Tubitak Scientific & Technical Research Council Turkey, 2015)In the present study, cytotoxic and apoptotic effects of melatonin were investigated on H-ras oncogene transformed rat embryo fibroblast 5RP7 cells. Melatonin inhibited cell growth and induced apoptosis in 5RP7 cells. We ... -
New Quinoline Based Sulfonamide Derivatives: Cytotoxic and Apoptotic Activity Evaluation Against Pancreatic Cancer Cells
Yurttaş, Leyla; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2018)Background: Quinoline is a privileged scaffold especially known with antimalarial and antibacterial drugs before, presently followed anticancer efficiency with a new group of protein kinase inhibitors. Objective: In this ... -
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
Turan, Gülhan; Yurttaş, Leyla; Tabbi, Aouatef; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Kaplancıklı, Zafer Asım (MDPI AG, 2018)In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
Yurttaş, Leyla; Ertaş, Merve; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel morpholine dithiocarbamate derivatives induces apoptosis in C6 glioma
Temel, Halide Edip; Çiftçi, Gülsen Akalın; Yurttaş, Leyla (Wiley-Blackwell, 2016)… -
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme ... -
Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women
Alataş, Özkan; Akalın, Ayşen; Çiftçi, Gülsen Akalın; Yorulmaz, Göknur; Ertorun, İpek; Kebapçı, Nur; Efe, Belgin (Walter De Gruyter GMBH, 2014)Objective: Obesity and age related vascular changes coupled with the effect of estrogen withdrawal increases predisposition to atherosclerosis in postmenopausal women. But the functions of high density lipoprotein (HDL) ... -
Phenolic Contents, in vitro Antioxidant and Cytotoxicity Activities of Salvia aethiopis L. and S. ceratophylla L. (Lamiaceae)
Eröz Poyraz, İlham; Çiftçi, Gülsen Akalın; Öztürk, Nilgün (Acg Publications, 2017)Along with present study it is designed to examine phenolic compositions, in vitro antioxidant and cytotoxicity activities of methanol and ethyl acetate extracts of Salvia aethiopis L. and S. ceratophylla L. (Lamiaceae) ... -
Pirimidin içeren bazı yeni 2,5-disübstitüe 1,3,4-oksadiazol türevlerinin sentezi ve sitotoksik ajan olarak değerlendirilmesi
Amaç: Kansere karşı günümüzde kullanılan ilaçların ilaç direnci, toksisite ve düşük biyoyararlanım gibi advers etkilerden dolayı, tedavide yeni antikanser ajanların varlığına ihtiyaç duyulmaktadır. Bu çalışmada pirimidin ... -
A preliminary investigation of anticancer activity of novel benzothiazole derivatives against A549 lung carcinoma cell line
Yurttaş, Leyla; Kaya Çavuşoğlu, Betül; Sever, Arda; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective(s): In this study, it was aimed to synthesize new chemotherapeutic agents based on known antiproliferative properties of benzothiazol-2-amine moiety. The antitumor activity of the newly synthesized compounds was ... -
Some Thiazole Derivatives Combined with Different Heterocycles: Cytotoxicity Evaluation and Apoptosis Inducing Studies
Yurttaş, Leyla; Demir, Bahar; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2018)Background: Thiazole ring is an outstanding structure found in many biologically active compounds and clinically available drugs. Because of synthesis simplicity of its derivatives and having a wide range of biological ... -
Synthesis and antiproliferative activity of new 1,5-disubstituted tetrazoles bearing hydrazone moiety
Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Özdemir, Ahmet; Turan, Gülhan; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Abu Mohsen, Usama (Springer Birkhauser, 2014)A new class of tetrazole-hydrazone derivatives including chloro-substituted phenyl moiety were synthesized to perform anticancer activity screening. The structural elucidation of the compounds was performed by IR, H-1 NMR, ...