Yazar "Dikmen, Miriş" için listeleme
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Effects of DNMT and HDAC Inhibitors (RG108 and Trichostatin A) on NGF-induced Neurite Outgrowth and Cellular Migration
Kaya-Tilki, Elif; Dikmen, Miriş; Öztürk, Yusuf (Asian Network Scientific Information-Ansinet, 2016)Neuropathological characteristics of neurodegenerative disorders are atrophy or loss of specific neurons in the specific brain areas. Small-molecule products like epigenetic drugs, which can activate silenced genes, regulate ... -
Escitalopram oxalate, a selective serotonin reuptake inhibitor, exhibits cytotoxic and apoptotic effects in glioma C6 cells
Dikmen, Miriş; Cantürk, Zerrin; Öztürk, Yusuf (Cambridge University Press, 2011)Objective: Various antidepressants, mainly tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), have been reported to exhibit potent anticancer properties in different cancer cells. In this ... -
Evaluation of Antiangiogenic and Antimetastatic Effects of Penicillium chrysogenum Secondary Metabolites
Dikmen, Miriş; Cantürk, Zerrin; Tilki, E. Kaya; EnGür, Selin (Medknow Publications & Media Pvt LTD, 2017)Development of resistance to standard therapy and toxic side effects are the major challenges encountered in chemotherapy of colorectal cancer. Increasing evidence has shown the ability of natural products to overcome ... -
Evaluation of neuritogenic activity of cultivated, wild and commercial roots of Gentiana lutea L.
Mustafa, Ahmed M.; Caprioli, Giovanni; Dikmen, Miriş; Kaya, Elif; Maggi, Filippo; Sagratini, Gianni; Öztürk, Yusuf (Elsevier Science BV, 2015)Several natural products have been proven to prevent neurodegenerative disorders by potentiating the action of nerve growth factor (NGF). Among them, secoiridoids have recently attracted interest for their potential use ... -
Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells
Dikmen, Miriş; Gökhaner, Gökhan; Cantürk, Zerrin (Lippincott Williams & Wilkins, 2019)Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and antiinflammatory effects. Aprepitant is used in vomiting and nausea, which are the most common side-effects of patients ... -
Evaluation of the Wound Healing Potentials of Two Subspecies of Hypericum perforatum on Cultured NIH3T3 Fibroblasts
Dikmen, Miriş; Öztürk, Yusuf; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Wiley-Blackwell, 2011)For centuries, Hypericum perforatum has been used in folk medicine to treat wounds. In the present study, the wound healing activities of extracts of H. perforatum ssp. perforatum (HPP) and H. perforatum ssp. veronense ... -
Helenalin'in yara iyileşmesi üzerindeki antienflamatuvar etkilerinin araştırılması
Dikmen, Miriş; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmakoloji Anabilim Dalı; Yüksel, Sevda Nur (Tez (yüksek lisans) - Anadolu Üniversitesi, 2019)Salvia hispanica L., chia adıyla bilinen, tropik ya da ılıman iklimde yetişen, beyaz ya da siyah renkli olup üzerinde koyu renkli noktalar bulunan Lamiaceae temsilcisidir. Bu çalışmada, S. hispanica tohumları metanol ve ... -
HepG2 hücrelerinde Vinkristin sülfat/?-viniferin kombinasyonunun vinkristin sülfat ile karşılaştırıldığında artmış etkinliğinin vurgulanması
Amaç: Bu çalışma HepG2 hücre hattında geç apoptoz ve mitokondriyal yolakta ?-viniferin (?-VNF)'in etkisini incelemek için dizayn edildi. Bu amaç için, HepG2 hücre dizisinde anti-kanser ilaç olarak kullanılan vinkristin ... -
Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms
Alyu, Feyza; Dikmen, Miriş (Cambridge University Press, 2017)Objective Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined ... -
Inhibition of C6 Glioma Cell Proliferation by Au(III) and Pt(II) Complexes of 1,10-Phenanthroline-5,6-dione
Dikmen, Miriş; Benkli, Kadriye; Öztürk, Yusuf (Asian Journal Of Chemistry, 2011)In this study, we studied the antiproliferative effecs of Au(III) and Pt(II) metal complexes of 1,10-phenanthroline-5,6-dione and cisplatin on rat glioma C6 cells. The antiproliferative effects were evaluated by MTT ... -
Inhibitory effects of secondary metabolites of halotolerant aspergillus terreus on angiogenesis
Dikmen, Miriş; Cantürk, Zerrin; Engür, Selin; Kaya, Tilki, E. (Scientific Publishers of India, 2017)Angiogenesis inhibitors have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. Fungi have been known (as) a wide useful source ... -
Inhibitory effects of secondary metabolites of halotolerant Aspergillus terreus on angiogenesis.
Dikmen, Miriş; Cantürk, Zerrin; Engür, Selin; Tilki, Kaya E. (Allied Acad, 2017)Angiogenesis inhibitors have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. Fungi have been known (as) a wide useful source ... -
Investigation of association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism frequency and plasma PAI-1 enzyme activity in patients with acute stroke
Küçükarabacı, Banu; Güneş, Hasan Veysi; Özdemir, Gazi; Coşan, Didem; Ozbabalik, Demet; Dikmen, Miriş; Değirmenci, İrfan (Mary Ann Liebert, Inc, 2008)Aim: This study was carried out to determine if there is any association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism and plasma PAI-1 enzyme activity in acute stroke patients. Methods: ... -
Investigation of the Apoptotic Effect of Curcumin in Human Leukemia HL-60 Cells by Using Flow Cytometry
Dikmen, Miriş; Cantürk, Zerrin; Öztürk, Yusuf; Tunalı, Yağmur (Mary Ann Liebert, Inc, 2010)Curcumin (diferuloylmethane), the major yellow pigment isolated from the turmeric (Curcuma longa), has received much attention due to several biological properties. Curcumin exhibits a variety of pharmacological effects ... -
Is there any role of G-protein estrogen receptor gene (GPR30) polymorphism in development of schizophrenia?
Özen, Murat Eren; Dikmen, Miriş; Tap, Duygu; Özler, Sinan; Yılmaz, Mehmet Bertan; Urhan Küçük, Meral (Cumhuriyet University Tip Fak Psikiyatri Anabilim Dali, 2019)Objectives: Schizophrenia is a complex neuropsychiatric disorder that affects approximately 1% of the population. Estrogens may play an important role in the etiology and treatment of this disorder. They mediate effect by ... -
Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)
Mustafa, Ahmed M.; Maggi, Filippo; Papa, Fabrizio; Kaya, Elif; Dikmen, Miriş; Öztürk, Yusuf (Elsevier Sci LTD, 2016)In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. ... -
İnsan lösemi (HL-60) hücre dizisinde piridin 2- karbaldoksim ligandı ve PT (II) kompleksinin apoptotik etkilerinin araştırılması
Alkan, Mediha (Anadolu Üniversitesi, 2010)Sisplatin, sisplatinyum ya da cis-diamindikloroplatinyum(II) (CDDP), lenfomalar, bazı karsinomlar, sarkomalar dahil pek çok kanser tipinde kullanılan platin kökenli bir kemoterapi ilacıdır. Karboplatin ve oksaliplatinin ... -
İnsan meme kanseri MCF7 hücre dizisinde fumagillinin antikanserojenik etkilerinin araştırılması
Yaramış, Adnan (Anadolu Üniversitesi, 2011)Meme kanseri, kadınlar arasında kanser nedenli ölümlerin başında yer almaktadır. Meme kanseri, semptomlarını göstermeden metastaz yapabilir. Özellikle, nonsteroidal anti-östrojen tedavide kullanılan tamoksifenin, meme anser ... -
Küçük molekül yapılı doğal bileşiklerin tümör gelişimi ve yayılımında yeni damar oluşumu hedefli tedavi potansiyellerinin epigenetik yaklaşım ve moleküler mekanizmalarla incelenmesi
Varol, Mehmet (Anadolu Üniversitesi, 2017)Likenler; mantar ve alglerin birliktelikleri sonucu oluşmuş simbiyotik ortaklıklardır ve bu birliktelik içinde kurulan ileri seviyeli metabolik ilişki sayesinde, 1000'den fazla özgün liken bileşiği sentezlenmektedir. Liken ...