Yazar "Kuş, Gökhan" için listeleme
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Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2
Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi; Kutlu, Hatice Mehtap (Springer, 2015)Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential ... -
The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro
Yıldız-Özer, Merve; Öztopçu-Vatan, Pınar; Kuş, Gökhan (Springer, 2018)Ceramide is found to be involved in inhibition of cell division and induction of apoptosis in certain tumour cells. Ceranib-2 is an agent that increases ceramide levels by inhibiting ceramidase in cancer cells. Therefore, ... -
Kısa zincirli sfingolipidlerin akciğer kanseri hücreleri üzerindeki etkileri
Kuş, Gökhan; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmakoloji Anabilim Dalı; Tağızade, Şehri (Anadolu Üniversitesi - Sağlık Bilimleri Enstitüsü, 2022)Akciğer kanseri henüz tedavisi bulunamamış tüm dünyada ölüm nedenlerinin baş sırasında yer alan küresel bir hastalıktır. Son zamanlarda bu alanda yapılan birçok çalışmanın da temel amacı apoptozis ile ilişkili düzenleyici ... -
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis
Kabadere, Selda; Kuş, Gökhan; Uyar, Ruhi; Öztopçu-Vatan, Pınar (Informa Healthcare, 2014)Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways ... -
Licofelone Inhibits Proliferation of Rat Hepatoma Cells
Öztopçu-Vatan, Pınar; Kuş, Gökhan; Man, Emine; Korkut, Melek Gunindi; Kabadere, Seida; Uyar, Ruhi (Zoological Soc Pakistan, 2017)Despite clinical treatments, hepatocellular carcinoma is one of the most common causes of cancer death. We tested whether licofelone, an inhibitor of both cyclooxygenase and lipoxygenase pathways of arachidonic acid ... -
Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats
Yelkenli, İbrahim Halil; Ulupınar, Emel; Korkmaz, Orhan Tansel; Şener, Erol; Kuş, Gökhan; Filiz, Zeynep; Tuncel, Neşe (Humana Press Inc, 2016)The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used in animal models of Parkinson's disease. In various neurodegenerative diseases, astrocytes play direct, active, and critical roles inmediating neuronal survival and ... -
Mooc'ler için animasyon destekli video modülleri tasarlama: Homeostasis örneği
Uzuner, Kubilay (Anadolu Üniversitesi, 2018)MOOClar açık ve uzaktan öğrenme alanında yoğun ilgi gören platformlar arasında yer almaktadır. Dünyanın önde gelen üniversiteleri MOOCların geliştirilmesi ve yaygınlaştırılması için önemli destekler sağlayarak herkese ... -
Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines
Ertekin, Rıfat; Özkurt, Mete; Kuş, Gökhan; Kabadere, Selda (Zoological Soc Pakistan, 2019)Prostate cancer is a common type of cancer. Contemporary treatment modalities require that new, effective methods or chemicals should be developed. Tolfenamic acid (TA) is a nonsteroidal anti-inflammatory medicine stimulating ... -
The role of hemostatic mechanisms in the development of thrombosis in Behcet's disease: an analysis by modified rotation thromboelastogram (ROTEM)
Bilge, N. Şule Yaşar; Akay, O. Meltem; Kaşifoğlu, Timuçin; Kuş, Gökhan; Korkmaz, Cengiz (Springer London LTD, 2013)Behcet's disease (BD) is a multisystemic disorder characterised by recurrent oral and genital ulcers. Vasculitis and thrombotic events are the most important causes of mortality. Thrombosis is the major clinical finding ... -
Sosyal ağ analizi ile turizm alanında yazılmış doktora tezlerinin araştırma konularının incelenmesi
Karagöz, Deniz; Yüncü, Rafet Hilmi (2013)Doktora tez çalışmaları bir alanın akademik anlamda ilerlemesinde önemli bir araç olarak görülmektedir. Turizm ala nında yazılmış doktora tezlerinin incelenmesi, turizmde akademik alanın hangi ölçüde geliştiğinin ve hangi ... -
A study into the level of first aid of hotel employees
Emir, Oktay; Kuş, Gökhan (Elsevier Science BV, 2015)Although many studies emphasize the importance of first aid training in saving human life, it is known that individuals are known to lack the adequate first aid knowledge and skill levels. In order to decrease the death ... -
Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Kabadere, Selda; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory ... -
Taxonomical Studies on Endemic Scorzonera Pygmaea Var. Pygmaea and Var. Nutans Stat. Nov (Asteraceae) From Turkey
Koyuncu, Onur; Yaylacı, Koray Ömer; Kuş, Gökhan (Pakistan Botanical Soc, 2014)The taxonomic status of Scorzonera pygmaea var. pygmaea and var. nutans belonging to the tribe. cichoreae (Asteraceae). S. pygmaea samples were collected from Arayit mountain. We suggest that these two subspecies should ... -
Taxonomical studies on endemic Scorzonera pygmaea var. pygmaea and var. nutans stat. nov. (Asteraceae) from Turkey
Koyuncu, O.; Yaylacı, Koray Ömer; Kuş, Gökhan (Pakistan Botanical Society, 2014)The taxonomic status of Scorzonera pygmaea var. pygmaea and var. nutans belonging to the tribe. cichoreae (Asteraceae). S. pygmaea samples were collected from Arayit mountain. We suggest that these two subspecies should ... -
Uzaktan Öğrenenlerin Sosyal Medya Kullanımlarına Yönelik Bir Araştırma: AöfAnadolum Örneği
Facebook Türkiye’de üniversite öğrencileri arasında en yaygın kullanılan sosyal paylaşım ağı olarak, bireylerin birbirleriyle etkileşim sağladıkları ortamlardan biridir. İlk kez 1960’lı yılların başlarında iletişim ...