Diğer Yayınlar Koleksiyonuhttps://hdl.handle.net/11421/137382024-03-29T15:48:43Z2024-03-29T15:48:43ZNew Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer ActivitiesTabbi, AouatefTebbani, DahmaneCaporale, AngelamariaSaturnino, CarmelaNabavi, S. F.Giuseppe, PalmaRastrelli, Lucahttps://hdl.handle.net/11421/139702019-10-19T16:02:54Z2017-01-01T00:00:00ZNew Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities
Tabbi, Aouatef; Tebbani, Dahmane; Caporale, Angelamaria; Saturnino, Carmela; Nabavi, S. F.; Giuseppe, Palma; Rastrelli, Luca
Background: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030. Result: The effect of these compounds was also tested in vitro as antitumor on Miapaca2 cells. Compounds also showed anticancer activity against human pancreas cancer cell MiaPaca2.
WOS: 000392081500012; PubMed ID: 27558673
2017-01-01T00:00:00Z