Sağlık Yönetimi
https://hdl.handle.net/11421/10140
2024-03-29T05:17:17ZAttitudes of Turkish speech and language therapists toward stuttering
https://hdl.handle.net/11421/22047
Attitudes of Turkish speech and language therapists toward stuttering
Maviş, İlknur; St Louis, Kenneth O.; Özdemir, Sertan; Togram, Bülent
Purpose: The study sought to identify clinical beliefs and attitudes of speech and language therapists (SLTs) in Turkey and to compare them to previous research on SLTs in the USA and UK. Method: The Clinician Attitudes Toward Stuttering (CATS) inventory was administered by mail to nearly all-practicing SLTs in Turkey (n = 61). Results: Turkish SLTs, whose caseloads contained a substantial number of people who stutter, agreed with CATS items suggesting psychological causes and problems for those who stutter. They strongly believed therapy should focus on parent counseling for preschoolers who stutter as well as adolescents. They were not optimistic about carrying out stuttering therapy nor about the likelihood that children who stutter could be effectively treated. Conclusion: Attitudes toward stuttering by clinicians who treat them are important considerations in the conduct and outcomes of stuttering therapy. Additionally, SLTs working with stuttering clients should benefit from professional views and clinical experiences of their colleagues from surveys such as this one. Educational objectives: The reader will be able to describe: (a) the components of the CATS, (b) common themes in Turkish speech and language therapists' attitudes toward stuttering, (c) differences between the attitudes of speech and language therapists from Turkey versus the United States and the United Kingdom
WOS: 000321881200008; PubMed ID: 23773668
2013-01-01T00:00:00ZThe role of hemostatic mechanisms in the development of thrombosis in Behcet's disease: an analysis by modified rotation thromboelastogram (ROTEM)
https://hdl.handle.net/11421/11554
The role of hemostatic mechanisms in the development of thrombosis in Behcet's disease: an analysis by modified rotation thromboelastogram (ROTEM)
Bilge, N. Şule Yaşar; Akay, O. Meltem; Kaşifoğlu, Timuçin; Kuş, Gökhan; Korkmaz, Cengiz
Behcet's disease (BD) is a multisystemic disorder characterised by recurrent oral and genital ulcers. Vasculitis and thrombotic events are the most important causes of mortality. Thrombosis is the major clinical finding in patients with BD, but the cause of the thrombosis is still unclear. Thromboelastography is an alternative method to evaluate almost all steps of the hemostatic system. Today, the modified rotation thromboelastogram (ROTEM) is a newer coagulation test and a more powerful technique. Our aim in this study was to investigate whether hemostatic mechanisms play a role in the development of thrombosis in BD patients by using ROTEM. Thirty BD patients, 20 ankylosing spondylitis patients, and 14 healthy controls who are not taking anti-aggregant or anti-coagulant therapy were included in the study. Whole blood count, protrombin time, activated protrombin time, fibrinogen, D-dimer levels, and ROTEM parameters (clotting time, clot formation time (CFT), and maximum clot formation(MCF)) were determined by INTEM and EXTEM analysis. Of the 30 patients with BD, 19 were women and 11 were men, and mean age was 40.6 +/- 11.2. Two of the BD patients had vascular involvement, but none of them were in active phase of the disease during the study. In INTEM assay, MCF (p < 0,001) value was significantly increased, and CFT (p > 0.05) value was decreased in BD patients compared with the control group. In the EXTEM assay, there was a similar significant increase in MCF (p=0.002) value and a decrease in CFT (p=0.002) value in BD patients compared with the control group. The results of our study indicated that primary hemostatic mechanisms which can be detected by ROTEM may play a role in the development of thrombosis in patients with BD.
WOS: 000327402500017; PubMed ID: 23975360
2013-01-01T00:00:00ZErythropoietin Protects the Kidney by Regulating the Effect of TNF-alpha in L-NAME-Induced Hypertensive Rats
https://hdl.handle.net/11421/11555
Erythropoietin Protects the Kidney by Regulating the Effect of TNF-alpha in L-NAME-Induced Hypertensive Rats
Özkurt, Mete; Uzuner, Kubilay; Erkasap, Nilüfer; Kuş, Gökhan; Özyurt, Rumeysa; Uysal, Onur; Kutlay, Özden
Background/Aims: Hypertension is the leading cause of death worldwide. Chronic high blood pressure induces inflammation. Tumor necrosis factor (TNF)-alpha plays a major role in inflammation and also depresses the synthesis of erythropoietin, which exerts protective effects on tissue; however, the mechanism is still unclear. We investigated the protective effect of erythropoietin against tissue damage caused by hypertension in the kidney and whether this effect was suppressed by TNF-alpha. Methods: First, we detected the optimum chronic dose for darbepoetin-alpha (Depo), which is a long-acting erythropoietin analog for rats. We separated 60 female adult rats into 6 groups: control, AP-nitro-L-arginine methyl ester hydrochloride (L-NAME), L-NAME+Depo, L-NAME+Remicade (an anti-TNF-alpha antibody), L-NAME+Depo+Remicade, Depo, and control. After 1 month of treatment, we measured cardiovascular parameters, took blood samples, sacrificed the rats, and removed kidneys for analyses. Results: The apoptotic index and the plasma and kidney mRNA levels of TNF-alpha increased in the L-NAME group and decreased in all other treatment groups. Macrophage accumulation increased in the L-NAME and L-NAME+Remicade groups, while it decreased in the Depo group. The mRNA abundance of TNF receptor 1 (TNFR1) decreased slightly in the Depo group and TNFR2 increased significantly in the same group. Conclusion: Erythropoietin protects kidney tissue against hypertension by preventing the apoptotic effects of TNF-alpha by blocking macrophage accumulation, decreasing TNF-alpha levels, and switching the TNF-alpha receptors from the apoptotic receptor TNFR1 to the proliferative receptor TNFR2
WOS: 000437352100014; PubMed ID: 29843153
2018-01-01T00:00:00ZBir koyunda akut şiddetli sistiserkozis olgusu. "Hepatitis cysticercosa, Pneumonitis cysticercosa ve Lymphadenitis cysticercosa"#
https://hdl.handle.net/11421/11557
Bir koyunda akut şiddetli sistiserkozis olgusu. "Hepatitis cysticercosa, Pneumonitis cysticercosa ve Lymphadenitis cysticercosa"#
Bozkurt, Fatih Mehmet; Eser, Mustafa; Demirel, Hasan Hüseyin
Cysticercus tenuicollis, köpek, tilki, çakal, kurt gibi karnivorların ince bağırsaklarında yaşayan Taenia hydatigena'nın larva formudur ve dünya üzerinde geniş bir yayılışa sahiptir. Bu form geviş getiren hayvanlar başta olmak üzere birçok küçük memeli hayvanda karaciğer dokusundaki göçü sırasında (Hepatitis cysticercosa) ve akciğerde (Pneumonitis cysticercosa) önemli patolojik bozukluklara sebep olur. Bu çalışmada Afyon Kocatepe Üniversitesi Veteriner Fakültesi Patoloji Anabilim Dalına getirilen 18 aylık bir koyunun ölüm sebebinin belirlenmesi amacıyla nekropsi yapılmış, organlar ve görülen patolojik lezyonlar paraziter açıdan değerlendirilmiştir. Nekropside karaciğer yüzeyinde birbirlerine paralel veya yer yer birbirlerini kesen yollar şeklinde çok sayıda kanama alanları ile içleri jelatinimsi sıvıyla dolu beyaz pirinç tanesi şeklinde parazit formasyonlarına rastlanmıştır. Bu değişiklikler aynı zamanda organın kesit yüzünde de görülmüştür. İç organlardan alınan kesitler tamponlu nötral formalin solüsyonunda 48 saat süreyle tespit edilmiştir. Doku takibinin ardından parafinde bloklanarak mikrotom aracılığı ile 5-6 mikron kalınlığında kesitler alınmıştır. Kesitlere hematoksilen-eozin (HE) boyası uygulanarak ışık mikroskobunda incelenmiştir. Histopatolojik incelemede karaciğerde, akciğerde ve mezenteriyel lenf yumrularında parazitin kistik formlarına ve bunun yol açtığı lezyonlara rastlanmıştır. Ayrıca kronik peritonitisin bu bulgulara eşlik ettiği dikkati çekmiştir. Sonuç olarak 18 aylık koyunda Hepatitis cysticercosa ve Pneumonitis cysticercosa ve Lenfadenitis cysticercosa yapan sistiserkoz vakası teşhis edilmiştir.; Cysticercus tenuicollis is larval form of Taenia hydatigena that lives in the small intestine of carnivores as dog, foxes, coyote, wolves and has a wide spread on the world. This form causes significant pathological disorder mainly during the migration in the liver (hepatitis cysticercosa) and lung (pneumonitis cysticercosa) especially in ruminants and many small mammals. In this study, necropsy was made determining of the cause of death of a 18 months sheep and it was evaluated organs and pathological lesions in terms of parasitic aspect which brought to Afyon Kocatepe University Faculty of Veterinary Medicine Department of Pathology. During necropsy, it was found large number of hemorrhages as shape of parallel or crossing each other on the liver surface and it was seen interference forms as shape of white rice which filled with gelatinous liquid. These changes were also seen on the cut surface of organ. The sections taken from internal organs were fixed in neutral buffered formalin for 48 hours. After the following of tissue, it was blocked in paraffin and the sections were obtained via tissue microtome with 5-6 micron. The sections were examined by light microscopy that applied hematoxylin-eosin (HE). It was found cystic forms of the parasite and it caused lesions in liver, lungs and mesenterial lymph nodes in the histopathological examination. In addition, it was noted, peritonitis is accompanied on these findings. As a result, cysticercosis case was diagnosed which caused Hepatitis cysticercosa, Pneumonitis cysticercosa and Lenfadenitis cysticercosa by 18 month sheep.
2015-01-01T00:00:00Z