Bildiri Koleksiyonu
https://hdl.handle.net/11421/13729
2024-03-29T09:25:59ZImproving sleep mask for eye contour care
https://hdl.handle.net/11421/13901
Improving sleep mask for eye contour care
Başyiğit, Zeynep Ömeroğulları; Hocaoğlu, E.; Kut, D.; Yenilmez, Evrim; Yazan, Yasemin
[No abstract available]
Johnson and Johnson;Keer; Fiber Society 2015 Fall Meeting and Technical Conference - Fibers: Where Tradition Meets Innovation -- 28 October 2015 through 30 October 2015 -- -- 121323
2015-01-01T00:00:00ZPreparation and in vitro evaluation of pyridostigmine bromide microparticles
https://hdl.handle.net/11421/13871
Preparation and in vitro evaluation of pyridostigmine bromide microparticles
Hegazy, N; Demirel, Müzeyyen; Yazan, Yasemin
Pyridostigmine bromide (PB) is an anticholinesterase agent whose aqueous solubility is high and which has a short elimination half-life. Its dosage rate in the treatment of myastenia gravis is frequent due to the short half-life and it exhibits side effects. Microparticles designed to deliver a pharmaceutical active ingredient efficiently at the minimum dose and also to enhance stability, reduce side effects and modify drug release were prepared in this study using an acrylic polymer (Eudragit) as the vehicle by the spray-drying technique. The drug was either dissolved or dispersed in the polymeric solution and following the preparation of microparticles using different ratios of ingredients, characterization studies including the determination of shape, particle size distribution, amount loaded, release and stability of PB were performed. The results obtained were compared to those of pure PB. Drug release from microparticles could be modified and was found to depend on the shapes of the microparticles. In vitro evaluation results indicate that the frequent dosage and side effects of pure PB may be reduced with the formulation of microparticles.
13th International Symposium on Microencapsulation -- SEP 05-07, 2001 -- ANGERS, FRANCE; WOS: 000179539900023; PubMed ID: 12176241
2002-01-01T00:00:00ZBioavailability of Verapamil Hydrochloride From Nasal Delivery Systems
https://hdl.handle.net/11421/13867
Bioavailability of Verapamil Hydrochloride From Nasal Delivery Systems
Yazan, Yasemin; Özer, Ay; Bozan, Berrin; Özdemir, M
Crommelin, D; Couvreur, P; Duchene, D
…
European Symposium on In Vitro and Ex Vivo Test Systems to Rationalize Drug Design and Delivery -- DEC 13-14, 1993 -- PARIS, FRANCE; WOS: A1994BA37V00044
1994-01-01T00:00:00ZInclusion complexes of fluconazole with beta-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation
https://hdl.handle.net/11421/13864
Inclusion complexes of fluconazole with beta-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation
Yurtdaş Kırımlıoğlu, Gülsel; Demirel, Müzeyyen; Genç, Lütfi
Fluconazole (FZ) is a triazole antifungal drug administered orally or intravenously. It is employed for the treatment of mycotic infections. However, the efficacy of FZ is limited with its poor aqueous solubility and low dissolution rate. One of the important pharmaceutical advantages of cyclodextrins is to improve pharmacological efficacy of drugs due to increasing their aqueous solubility. The aim of present study was to prepare an inclusion complex of FZ and beta-cyclodextrin (beta-CD) to improve the physicochemical and biopharmaceutical properties of FZ. The effects of beta-CD on the solubility of FZ were investigated according to the phase solubility technique. Complexes were prepared with 1: 1 M ratio by different methods namely, freeze-drying, spray-drying, co-evaporation and kneading. For the characterization of FZ/beta-CD complex, FZ amount, practical yield %, thermal, aqueous solubility, XRD, FT-IR and NMR (H-1 and C-13) analysis were performed. In vitro dissolution from hard cellulose capsules containing FZ/beta-CD complexes was compared to pure FZ and its commercial capsules and evaluated by f(1) (difference) and f(2) (similarity) factors. Paddle method defined in USP 31 together with high pressure liquid chromatographic method were used in in vitro dissolution experiments. It was found that solubility enhancement by FZ/beta-CD complexes depends on the type of the preparation method. High release of active agent from hard cellulose capsules prepared with beta-CD complexes compared to commercial capsules was attributed to the interactions between beta-CD and active agent, high energetic amorphous state and inclusion complex formation.
15th International Cyclodextrin Symposium -- MAY 09-12, 2010 -- Vienna, AUSTRIA; WOS: 000294963800024
2011-01-01T00:00:00Z