Diğer Yayınlar Koleksiyonu
https://hdl.handle.net/11421/13734
2024-03-28T12:34:15Z
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Composition of some herbal slimming tea preparations marketed in Turkey and their possible adverse effects [Türkiye'de satilan bazi bitkisel zayiflama çaylarinin i·çerikleri ve bu çaylarin kullanimina bagli ortaya çikabilecek i·stenmeyen etkiler]
https://hdl.handle.net/11421/13958
Composition of some herbal slimming tea preparations marketed in Turkey and their possible adverse effects [Türkiye'de satilan bazi bitkisel zayiflama çaylarinin i·çerikleri ve bu çaylarin kullanimina bagli ortaya çikabilecek i·stenmeyen etkiler]
Saraçoğlu, Ahmet; Ergün, Bülent
Objective: The interest in herbal products has been increasing in recent years. Herbal weight-loss products are widely used because they are believed to be harmless, especially among women who want to lose weight. However, these products may cause numerous adverse effects especially when used persistently. Material and Methods: In this study, the compositions of 13 different herbal form tea preparations, marketed in Turkey, were investigated and the possible adverse effects related to their use and risk factors were evaluated by reviewing the literature. Results: Senna was the most commonly used plant in the herbal form tea preparations marketed in Turkey. None of the investigated samples included plants containing ephedrine. The samples were not standardized. Conclusion: Literature suggests that plants used in these products may cause many adverse effects. For this reason, these products should be used under the control of health care professionals. Copyright © 2006 by Türkiye Klinikleri.
2006-01-01T00:00:00Z
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Ketamine: A popular recreational drug: Review [Ketamin: Popüler bir keyif verici i·laç]
https://hdl.handle.net/11421/13955
Ketamine: A popular recreational drug: Review [Ketamin: Popüler bir keyif verici i·laç]
Saraçoğlu, Ahmet
Ketamine is an anaesthetic agent, characterised by rapid onset of action with profound analgesic and moderate hypnotic properties. Today, the pharmacological use of ketamine is limited. However, because of its hallucinogenic effects, ketamine began to be abused soon after its introduction into clinical use and in recent years its illicit use has tended to increase. Ketamine HCl is a white, crystalline powder, having a slight, characteristic odor. The tasteless, colorless and nearly odorless characteristics of ketamine have made it an increasingly common illicit drug. In humans, ketamine is metabolised into norketamine, the pharmacologically active metabolite, and dehydronorketamine by the liver cytochrome P-450 enzyme system. The pharmacodynamic mechanism of ketamine is complex. The substance interacts with numerous receptors in the brain including N-methyl-D-aspartate (NMDA), opioid, muscarinic, cholinergic and nicotinic receptors. In acute use, sub-anaesthetic doses of ketamine produces schizophrenic-like and dissociative symptoms and impairs cognitive function. Both the positive and negative symptoms of schizophrenia are observed in ketamine-induced psychosis. The drug is abused primarily by young people who frequent dance and rave parties and is popular among some gay and bisexual men. The acute effects induced by ketamine generally last 15-45 minutes after drug administration. It is often used in combination with other drugs. Little is known about the chronic effects of the agent. Ketamine leads to development of dependence in a manner resembling cocaine dependence. Copyright © 2005 by Türkiye Klinikleri.
2005-01-01T00:00:00Z
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Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress (vol 2018, 7196142, 2018)
https://hdl.handle.net/11421/13940
Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress (vol 2018, 7196142, 2018)
Ilgın, Sinem; Aydoğan-Kılıç, Gözde; Baysal, Merve; Kılıç, Volkan; Ardıç, Mina; Ucarcan, Seyda; Atlı, Özlem
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WOS: 000450727800001
2018-01-01T00:00:00Z
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Is N-acetyl cysteine protective against monocrotaline-induced toxicity?
https://hdl.handle.net/11421/13945
Is N-acetyl cysteine protective against monocrotaline-induced toxicity?
Karagöz, Şerife; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Perk, Başak Özlem; Burukoğlu, Dilek; Ergün, Bülent; Sırmagül, Başar
Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form of herbal medicine preparations. The aim of this study was to observe the protective effect of N-acetyl cysteine (NAC) on MCT-induced pulmonary toxicity and hepatotoxicity. According to our results (right ventricular pressures [RVPs], ratios of right ventricle (RV)/heart weight (HW), plasma AST levels, liver glutathione levels, liver MDA levels and liver histopathological examinations of groups), protective effects were observed with NAC treatment in both MCT-induced pulmonary toxicity and hepatotoxicity.
WOS: 000322025000003
2013-01-01T00:00:00Z