Kurum Yazarı "Temel, Halide Edip" WoS İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Sağlık, Begüm Nurpelin; Demir, Bahar; Levent, Serkan (Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
Temel, Halide Edip; Temel, Tuncer; Cansu, Dondu Üsküdar; Özakyol, Ayşegül (Clin Lab Publ, 2015)Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more ... -
Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
Temel, Halide Edip; Demirci, Betül; Demirci, Fatih; Celep, Ferhat; Kahraman, Ahmet; Doğan, Musa; Başer, K. Hüsnü Can (Taylor & Francis Inc, 2016)Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
Yıldırım, Abidin; Başesikoğlu, Barbaros; Temel, Halide Edip; Erkasap, Nilüfer; Yenilmez, Aydın; Uslu, Sema; Dönmez, Turgut (Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
Akyüz, Fahrettin; Tekin, Neslihan; Aydın, Özlem; Temel, Halide Edip; Işıklı, Burhanettin (Academic Journals, 2012)The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ... -
Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
Akyüz, Fahrettin; Aydın, Özlem; Aydın, Tayfun; Tekin, Neslihan; Temel, Halide Edip; Burukoğlu, Dilek; Aral, Erinç (Turkish Biochem Soc, 2012)Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation ... -
EFFECTS of Aspirin Overdose ON BalfVEGF of Endotoxemic Rats
Aydın, Özlem; Tekin, Neslihan; Aydın, Tayfun; Temel, Halide Edip; Burukoğlu, Dilek; Aral, Erinç; Akyüz, Fahrettin (Taylor & Francis Inc, 2010)… -
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
Uslu, S.; Özçelik, E.; Kebapçı, N.; Temel, Halide Edip; Demirci, Fatih; Ergün, Bülent; Demirüstü, C. (Springer London LTD, 2016)Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase ... -
The impact of klotho gene polymorphisms on urinary tract stone disease
Gürel, Abdullah; Ure, Iyimser; Temel, Halide Edip; Çilingir, Oğuz; Uslu, Sema; Celayir, Mehmet Fatih; Başesikoğlu, Ali Barbaros (Springer, 2016)To investigate the effect of klotho gene and beta-glucuronidase activity on stone formation in patients with urinary tract stone disease (UTSD). A total of 103 patients with UTSD and 102 controls with no specific urolithiasis ... -
In vitro biological and toxicological evaluation of Lathyrus sp extracts
Polatoğlu, Kaan; Göğer, Fatih; Temel, Halide Edip; Demirci, Fatih (Georg Thieme Verlag Kg, 2015)… -
Inhibitory effect of Calamintha nepeta subsp glandulosa essential oil on lipoxygenase
Demirci, Betül; Temel, Halide Edip; Portakal, Tuba; Kırmızıbekmez, Hasan; Demirci, Fatih; Başer, K. Hüsnü Can (Walter De Gruyter GMBH, 2011)Objective: Scavenging of free radicals and inhibition of lipoxygenase are important target in the treatment of a variety of inflammatory diseases. Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) P.W. Ball of Lamiaceae ... -
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
Turan, Gülhan; Yurttaş, Leyla; Tabbi, Aouatef; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Kaplancıklı, Zafer Asım (MDPI AG, 2018)In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ... -
Novel morpholine dithiocarbamate derivatives induces apoptosis in C6 glioma
Temel, Halide Edip; Çiftçi, Gülsen Akalın; Yurttaş, Leyla (Wiley-Blackwell, 2016)… -
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme ... -
Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats
Saraçoğlu, Ahmet; Temel, Halide Edip; Ergün, Bülent; Çolak, Ömer (Taylor & Francis Inc, 2009)In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were ...