Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 132, listelenen: 26-45
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Calmodulin content and in vitro contractility of duodenum from streptozotocin-induced diabetic rats: Effects of insulin therapy and calmodulin antagonism
(Elsevier Science BV, 1997)The effects of experimental diabetes and insulin treatment on the decreased reactivity of isolated rat duodenum to KCI and calmidazolium, a specific calmodulin antagonist, were examined. After 8 weeks of streptozotocin ... -
Camellia sinensis increased apoptosis on U2OS osteosarcoma cells and wound healing potential on NIH3T3 fibroblast cells
(Springer, 2017)Camellia sinensis (Cs) is a plant which is rich in polyphenols and has antioxidant, antiinflammatory, antimutagenic, anticarcinogenic and antibacterial activities. In this study, two different methanol extracts (Cs-I and ... -
Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms
(Wiley, 2013)Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium Willd. (Guttiferae) on behavioral parameters and pain perceptions of mice were investigated in this study. Depression, anxiety, ... -
The Centrally-Mediated Mechanisms of Action of Ferulic Acid-Induced Antinociception
(Marmara University, Fac Medicine, 2016)This study aimed to investigate the central antinociceptive effects of ferulic acid, a common phenolic compound found in various medicinal plants used for pain relief, and the contribution of cholinergic, serotonergic, ... -
Chronic heavy ethanol consumption is associated with decreased platelet aggregation in rats
(Tohoku University Medical Press, 2005)Although moderate alcohol consumption seems to be protective against atherosclerosis, coronary artery disease rate increases with its higher doses. Platelet aggregation is an important process which contributes to the ... -
Comparative Studies on Phenolic Composition, Antioxidant, Wound Healing and Cytotoxic Activities of Selected Achillea L. Species Growing in Turkey
(MDPI AG, 2015)Turkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata ... -
Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells
(Taylor & Francis LTD, 2016)Inhibition of the proteasome has emerged as a clinically effective anticancer therapeutic approach in recent years. Bortezomib (Velcade (R)) showed extremely high potency against a wide range of cancer cell lines. Ixazomib ... -
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth
(Mary Ann Liebert, Inc, 2017)DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel drugs, especially for neurodegenerative disorders. In recent years, there has been increased interest in small molecules that can ... -
Composition of the essential oil of Cachrys alpina bieb.
(Allured Publ Corp, 2004)A hydrodistilled essential oil from fruits of Cachrysalpina,was analyzed by GUMS. Twenty-nine compounds representing 98% of the oil were identified with alpha-humulene (33.1%), p-cymene (9.3%). alpha-phellandrene (9.1%) ... -
A computer experiment model to investigate the effects of drug dosage in animals, for use in pharmacological education and research
(2011)The ACD-IDEA database, which was originally developed by the authors in 2004, is an ongoing compilation of existing data on the in vivo doses of compounds at which various responses in certain animal species have been ... -
A Computer Experiment Model to Investigate the Effects of Drug Dosage in Animals, for Use in Pharmacological Education and Research
(Frame, 2011)The ACD-IDEA database, which was originally developed by the authors in 2004, is an ongoing compilation of existing data on the in vivo doses of compounds at which various responses in certain animal species have been ... -
Cytotoxic and inhibitory effects of pomegranate peel extract on proliferation of MCF-7 cells [Nar meyve kabugu ekstresi·ni·n mcf-7 hücre proli·ferasyonu üzeri·ne si·totoksi·k ve i·nhi·bi·tör etki·leri·]
(2008)The Pomegranate (Punica granatum L.) is a wonderful fruit which contains a wide variety of precious phytochemical compounds applicable in the fields of therapeutics and health care. Previous studies have demonstrated the ... -
Decreased Beta-Adrenergic Responses of Rat Small-Intestine Due to Non-Insulin-Dependent Diabetes
(Elsevier Sci Ireland LTD, 1990)… -
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines
(Pergamon-Elsevier Science LTD, 2016)In the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (AChE) inhibitors. The target compounds were synthesised in three steps. Structures ... -
Dexketoprofen trometamol loaded solid lipid nanoparticles(SLNs): Formulation, in vitroand in vivoevaluation
(2020)Development, in vitroand in vivoevaluation of dexketoprofen trometamol (DT)-loaded nanosizeddrugdelivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe ... -
Dopamine D2 receptor gene-141C Insertion/Deletion polymorphism in Turkish schizophrenic patients
(Springer, 2011)Schizophrenia is a chronic and neuropsychiatric disease that affects about 0.5-1% of the world's population. An increase in dopamine and dopamine D2 receptor (DRD2) gene products has been well described in schizophrenic ... -
The Effect of Agomelatine Treatment on Diabetes-Induced Cognitive Impairments in Rats: Concomitant Alterations in the Hippocampal Neuron Numbers
(MDPI, 2018)Researches that are related to the central nervous system complications of diabetes have indicated higher incidence of cognitive disorders in patients. Since the variety of nootropic drugs used in clinics is limited and ... -
Effect of an aqueous distillate of Origanum onites L. on isolated rat fundus, duodenum and ileum: Evidence for the role of oxygenated monoterpenes
(Govi-Verlag Pharmazeutischer Verlag GMBH, 2005)The aqueous distillate of Origanum onites L. (Labiatae) was reported to have various ethnomedical uses including effects on the gastrointestinal tract. The effects of three different doses (0.1, 0.2 and 0.4 mL) of the ... -
Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits
(Polish Acad Sciences Inst Pharmacology, 2012)Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's ... -
Effect of lithium on gastro-intestinal complications in alloxan-diabetic rats
(1992)1. 1. Decreased ß-adrenergic and serotonergic responses have been reported in gastro-intestinal tract of experimentally diabetic rats. Effects of lithium on the decreased ß-adrenergic and serotonergic responsiveness of the ...
