Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 132, listelenen: 94-113
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MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro
(2004)In this study, the possible effects of MgSO 4 and lazaroid (U-83836E) on glutamate toxicity on glial cells were investigated. C6 and human glioblastoma multiforme cells derived from two patients were grown in an incubator. ... -
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ... -
Mianserin’in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin’in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin’in ... -
Mirtazapin Diyabet Oluşturulan Sıçanların Beyinciklerindeki Hasarı Kısmen Düzeltmektedir
(2018)Diabetes mellitus (DM) sistemik bir hastalık olup çeşitli organlarda hasara neden olmaktadır. Bu organlar arasında beyincik de yer almaktadır. Mirtazapin ise majör depresyon tedavisinde kullanılan bir antidepresan madde ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
(Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
mTOR Inhibitors in the Treatment of Cancer
(Marmara University, Fac Pharmacy, 2015)The mammalian target of rapamycin (mTOR) is a highly conserved in evolution serine/threonine kinase belonging to the phosphatidylinositol kinase related protein kinases family. mTOR plays a central role in regulation of a ... -
Nepetalactone: A new opioid analgesic from Nepeta caesarea Boiss.
(Royal Pharmaceutical Soc Great Britain, 1998)The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nude, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5 degrees C) methods. Of the ... -
Neuritogenic Activity of Epigallocatechin Gallate and Curcumin Combination on Rat Adrenal Pheochromocytoma Cells
(Parlar Scientific Publications (PSP), 2017)Plant phytochemicals are important neuroprotective agents which mainly act as antioxidants by scavenging stress -induced free radicals in the brain. Phytochemicals from medicinal plants including epigallocatechin gallate ... -
New antidepressant drug candidate: Hypericum montbretti extract
(Taylor & Francis LTD, 2011)This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic ... -
New beta-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
(Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5-dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ... -
New ß-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
(1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5- dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
(Elsevier Science BV, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits
(Wiley, 2018)ObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, ... -
On the relaxant actions of some benzimidazole derivatives on the rat duodenum: Approaches to the mechanism
(1986)[No abstract available] -
Opioid system mediated anti-nociceptive effect of agomelatine in mice
(Pergamon-Elsevier Science LTD, 2016)Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ... -
Pharmacological and toxicological effects of gas plant (Dictamnus Albus L.)
(2005)Bu çalışmanın amacı Akgiritotu'nun farmakolojik ve toksikolojik etkilerini araştırmaktır. Yaprak ve meyvalarmdan hazırlanan sulu ekstreler kobay derisi üzerinde 2,4-dinitrobenzen ile karşılaştırmalı olarak test edilmiştir. ... -
Pharmacological effects of rutin
(1991)It is well-known that flavonoids including rutin exert a wide range of pharmacological effects. This study was carried out for further characterization of the pharmacological effect of rutin. A significant rise in the serum ...
