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Toplam kayıt 116, listelenen: 1-10
Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: A study on mechanism of action
(Elsevier Science BV, 2015)
This study used various experimental pain methods to investigate the effects of subacute mianserin administration on diabetes-induced neuropathic pain in rats. The effect of mianserin on hyperalgesia occurring in connection ...
The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet
(Lippincott Williams & Wilkins, 2012)
The aim of this study was to examine the effect of simvastatin (SMV), a 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor, in rats fed with a standard or a high-fat diet (HFD) throughout the prenatal and the postnatal ...
Antioxidant, Antiproliferative and Apoptotic Effects of Secondary Metabolites of Halotolerant Aspergillus terreus on Colon Adenocarcinoma Caco-2 Cells
(Asian Network Scientific Information-Ansinet, 2017)
Objective: This study aimed to investigate the antioxidant and anticancer effects of the secondary metabolites of halotolerant Aspergillus terreus-2 (hAt-2) on colon adenocarcinoma (Caco-2) cells. The hAt-2 was isolated ...
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth
(Mary Ann Liebert, Inc, 2017)
DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel drugs, especially for neurodegenerative disorders. In recent years, there has been increased interest in small molecules that can ...
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
(Elsevier GMBH, 2019)
Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ...
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
(Pharmaceutical Soc Korea, 2013)
In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ...
Evaluation of neuritogenic activity of cultivated, wild and commercial roots of Gentiana lutea L.
(Elsevier Science BV, 2015)
Several natural products have been proven to prevent neurodegenerative disorders by potentiating the action of nerve growth factor (NGF). Among them, secoiridoids have recently attracted interest for their potential use ...
The hepatoprotective effects of Hypericum perforatum L. on hepatic ischemia/reperfusion injury in rats
(Springer, 2014)
Little is known about the effective role of Hypericum perforatum on hepatic ischemia-reperfusion (I/R) injury in rats. Hence, albino rats were subjected to 45 min of hepatic ischemia followed by 60 min of reperfusion period. ...
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
(2003)
Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ...
Evaluation of Antiangiogenic and Antimetastatic Effects of Penicillium chrysogenum Secondary Metabolites
(Medknow Publications & Media Pvt LTD, 2017)
Development of resistance to standard therapy and toxic side effects are the major challenges encountered in chemotherapy of colorectal cancer. Increasing evidence has shown the ability of natural products to overcome ...