Kurum Yazarı "Altıntop, Mehlika Dilek" Makale Koleksiyonu İçin Listeleme
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Antifungal Effects of Some Oxadiazole Derivatives on Pathogenic Molds
Bazı oksadiazol türevleri Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum 'a karşı in vitro olarak test edilmiştir. Butün bileşikler en yüksek ... -
Antifungal effects of some oxadiazole derivatives on pathogenic molds [Bazi{dotless} oksadiazol türevlerinin patojenik küfler üzerindeki antifungal etkileri]
Some oxadiazole derivatives were tested in vitro against Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum. All compounds showed the highest ... -
Antifungal, mosquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives
Tabanca, Nurhayat; Wedge, David E.; Ali, Abbas; Khan, Ikhlas A.; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek (Springer Birkhauser, 2013)Hydrazone derivatives possess good antifungal and insecticidal activities and their structures are used in pesticide design. In the present study, for the first time, ten hydrazone derivatives (1-10) were evaluated for ... -
Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
Sever, Belgin; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Bloomquist, Jeffrey R. (Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı; 0000-0003-4847-9711; 0000-0001-5098-8967; 0000-0003-0280-5550; 0000-0002-8159-663X; Sever, Belgin; Akalın Çiftçi, Gülşen; Özdemir, Ahmet; Altıntop, Mehlika Dilek (2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Sever, Belgin; Altıntop, Mehlika Dilek; Radwan, M. O.; Özdemir, Ahmet; Otsuka, Masami; Fujita, M.; Çiftçi, H. I. (Elsevier Masson SAS, 2019)Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet; Altıntop, Mehlika Dilek (Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
Altıntop, Mehlika Dilek; Çiftçi, Halil İbrahim; Radwan, Mohamed O.; Sever, Belgin; Kaplancıklı, Zafer Asım; Ali, Taha F. S.; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ... -
Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1-10) were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma, and NIH/3T3 ... -
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Tilki, Elif Kaya; Dikmen, Miriş (MDPI, 2018)Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Osmaniye, Derya; Sağlık, Begüm Nurpelin, Begüm N.; Özdemir, Ahmet (Wiley-V C H Verlag GMBH, 2018)In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones ... -
Eskişehir'de Vitamin Kullanım Alışkanlıkları Üzerine Dar Kapsamlı Bir Araştırma
Bu çalışmada, Eskişehir'de dört farklı sosyo-kültürel grubu temsil eden 500 kişinin vitamin kullanım alışkanlıkları ve bu alışkanlıkları etkileyen faktörler çalışılmıştır. Araştırmaya katılan denekler tesadüfi örnekleme ... -
In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity
Sever, Belgin; Küçükoğlu, Kaan; Nadaroğlu, Hayrunnisa; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2019)Background: Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification. Objective: Based on antioxidative properties of ... -
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
Sever, Belgin; Altıntop, Mehlika Dilek; Kuş, Gökhan; Özkurt, Mete; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1-8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1(4-chlorobenzoyl)- ... -
Investigation of the inhibitory effects of isoindoline-1,3-dion derivatives on hCA-I and hCA-II enzyme activities
Nadaroğlu, H.; Güngör, A. A.; Gündoğdu, Ö.; Kishali, N. H.; Sever, Belgin; Altıntop, Mehlika Dilek (Elsevier B.V., 2019)Inhibition of carbonic anhydrase (CA) has emerged as a promising approach for the treatment of a variety of diseases such as glaucoma, epilepsy, obesity and cancer. As a result, the design of CA inhibitors (CAIs) is an ... -
A mini-survey on vitamin usage habits in eskİşehİr [Eskişehir'de vitamin kullamm ahskanhklari{dotless} üzerine dar kapsamh bir araşti{dotless}rma]
In the present study, vitamin usage habits of five hundred people representing four different socio-cultural groups in Eskişehir and the factors affecting these habits were studied. The participants of the research were ... -
New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2019)Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the ... -
New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ...