Kurum Yazarı "Altıntop, Mehlika Dilek" Makale Koleksiyonu İçin Listeleme
-
Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Sever, Belgin; Baysal, Merve; Temel, Halide Edip; Özdemir, Ahmet (Bentham Science Publ LTD, 2017)Background: In recent years, the relationship between overexpression of matrix metalloproteinases ( MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs. Objective: The ... -
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Turan, Gülhan; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and ... -
Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents
Altıntop, Mehlika Dilek; Abu Mohsen, Usama; Karaca, Hülya; Cantürk, Zerrin; Özdemir, Ahmet (Bentham Science Publ LTD, 2014)In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazo ... -
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New bis-thiazole derivatives (1-10) were synthesized via the ring closure of 1,1'-(3,3'-dimethoxybipheny1-4,4'-diyl)bis(thiourea) with phenacyl bromides and evaluated for their cytotoxic effects on A549 human lung ... -
Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Kabadere, Selda; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
Altıntop, Mehlika Dilek; Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım (MDPI AG, 2016)In the current work, new 1,3,4-thiadiazole derivatives were synthesized and investigated for their antinociceptive effects on nociceptive pathways of nervous system. The effects of these compounds against mechanical, thermal ... -
Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Gülhan (MDPI, 2015)In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test ... -
Synthesis and evaluation of new benzodioxole-based dithiocarbamate derivatives as potential anticancer agents and hCA-I and hCA-II inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Küçükoğlu, Kaan; Özdemir, Ahmet; Soleimani, Seyedeh Sara; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the current work, new benzodioxole-based dithiocarbamate derivatives were synthesized via the reaction of N-(1,3-benzodioxol-5-ylmethyl)-2-chloroacetamide with appropriate sodium salts of N,N-disubstituted dithiocarbamic ... -
Synthesis and Evaluation of New Benzodioxole-Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
Altıntop, Mehlika Dilek; Temel, Halide Edip; Sever, Belgin; Çiftçi, Gülsen Akalın; Kaplancıklı, Zafer Asım (MDPI, 2016)New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to ... -
Synthesis and evaluation of new benzoxazole derivatives as potential antiglioma agents
Altıntop, Mehlika Dilek; Akalın Çiftçi, Gülsen; Edip Temel, Halide (Marmara University, 2018)Gliomas account for the majority of human brain tumors and the incidence of gliomas is expected to rise in upcoming years and therefore extensive efforts have been devoted to the discovery of potent antiglioma agents. Due ... -
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Turan, Gülhan; Çiftçi, Gülsen Akalın; Ertorun, İpek; Alataş, Özkan; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the present work, new indole-based chalcone derivatives were obtained via the reaction of 5-substituted-1H-indole-3-carboxaldehydes/1-methylindole-3-carboxaldehyde with appropriate acetophenones. The synthesized compounds ... -
Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Temel, Halide Edip; Atlı Eklioğlu, Özlem; Baysal, Merve; Demirci, Fatih (MDPI, 2017)Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic ... -
Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
Karabacak, Muhammed; Altıntop, Mehlika Dilek; Çiftçi, Halil İbrahim; Koga, Ryoko; Otsuka, Masami; Fujita, Mikako; Özdemir, Ahmet (MDPI AG, 2015)New pyrazoline derivatives were synthesized and evaluated for their cytotoxic effects on AsPC-1 human pancreatic adenocarcinoma, U87 and U251 human glioblastoma cell lines. 1-[((5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl)th ... -
Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II)
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Küçükoğlu, Kaan; Turan, Gülhan; Nadaroğlu, Hayrunnisa; Kaplancıklı, Zafer Asım (Informa Healthcare, 2015)2-[[5-(2,4-Difluoro/dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio] acetophenone derivatives (3a-s) were designed as human carbonic anhydrase isozymes (hCA-I and hCA-II) inhibitors and synthesized. hCA-I and hCA-II were ... -
Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Atlı Eklioğlu, Özlem; Cantürk, Zerrin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2016)In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT assay was carried out to determine ... -
Synthesis and Evaluation of New Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
Kaplancıklı, Zafer Asım; Sever, Belgin; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Baysal, Merve; Özdemir, Ahmet (Bentham Science Publ LTD, 2017)Background: In recent years, thiazole derivatives incorporated with hydrazone moiety have attracted a great deal of interest due to their pivotal role in the field of current cancer research. Methods: In the present study, ... -
Synthesis and Evaluation of Tetrazole-Based Hydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2015)2-[(1-Methyl/Phenyl-1H-tetrazol-5-yl)thio]-N'-[(aryl) methylidene/ethylidene] acetohydrazides were synthesized and investigated in vitro against pathogenic bacteria and Candida species for their antimicrobial activity using ... -
Synthesis and Evaluation of Thiazole - Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Demirci, Fatih; Ilgın, Sinem; Göğer, Gamze (Springer, 2014)The aim of this study was to describe the synthesis of four new 2-(3,4-diphenyl-3H-thiazol-2-ylidene)amino-4,6-dimethylpyrimidine derivatives, which were screened for their anticandidal activity and cytotoxicity. The title ... -
Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2015)Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives were investigated for their antimicrobial ... -
Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirci, Fatih; Kaplancıklı, Zafer Asım (MDPI AG, 2014)Fourteen new thiazolyl hydrazone derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 2-[2-((5-(4-chloro-2-nitrophenyl) furan-2-yl) ...