Makale Koleksiyonu: Recent submissions
Now showing items 1-20 of 132
-
Dexketoprofen trometamol loaded solid lipid nanoparticles(SLNs): Formulation, in vitroand in vivoevaluation
(2020)Development, in vitroand in vivoevaluation of dexketoprofen trometamol (DT)-loaded nanosizeddrugdelivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe ... -
Prunus spinosa L. meyvelerinin deneysel yara iyileşmesi üzerine etkileri
(2017)Farelerde oluşturduğumuz deneysel yara modellerinde, Prunus Spinosa L. metanollü meyve ekstresini kullanarak, bu ekstrenin yara iyileşmesindeki etkisini araştırdık. Otuz iki adet C57/Black fare ile 4 deney grubu oluşturuldu. ... -
Mirtazapin Diyabet Oluşturulan Sıçanların Beyinciklerindeki Hasarı Kısmen Düzeltmektedir
(2018)Diabetes mellitus (DM) sistemik bir hastalık olup çeşitli organlarda hasara neden olmaktadır. Bu organlar arasında beyincik de yer almaktadır. Mirtazapin ise majör depresyon tedavisinde kullanılan bir antidepresan madde ... -
Essential Oil Composition of Three Centaurea Species from Turkey: Centaurea aggregata Fisch. & Mey. ex. DC.subsp. aggregata, C. balsamita Lam. and C. behen L.
(2017)The essential oils of Centaurea aggregata subsp. aggregata, C. balsamita and C. behen collected in the same habitat from Turkey, have been investigated. A total of 26, 54 and 26 components were identified in C. aggregata ... -
Mianserin’in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin’in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin’in ... -
Effects of Prunus spinosa L. Fruits on experimental wound healing [Prunus spinosa L. Meyvelerinin deneysel yara iyileşmesi üzerine etkileri]
(Logos Medical Publishing, 2017)We investigated the wound healing efficacy of the methanol extracts of Prunus spinosa L. fruits using an excisional cutaneous wound model in mice. We used 32 C57/Black mice equally divided into four groups. Group 1 Control, ... -
Extract of hypericum perforatum blocks nicotine-induced locomotor activitiy in mice
(2006)Sunulan çalışmada, farelerde nikotin ile indüklenen lokomotor aktivite üzerine Hiperikum perforatum ekstresinin etkileri incelenmiştir. Çalışmada denek olarak erişkin erkek Swiss-Webster türü fareler kullanıldı. Nikotin ... -
Serotonerjık ve Noradrenerjık Modülasyonun Rosmarınık Asıt Analjezısıne Katkısı
(2017)Bu çalışmada, 0.3, 1 ve 3 mg/kg (p.o.) rosmarinik asitinfarelerde santral analjezik etkinliğinin sıcak-plaka vekuyruk-batırma testleri, periferal analjezik etkinliğininise asetik asit ile indüklenen kıvranma-testi ile ... -
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ... -
1,3,5-triaril-4,5-dihidro-1h-pirazol türevi bazı bileşiklerin benzodiazepin reseptörleri aracılıklı anksiyolitik-benzeri etkileri
(2016)Amaç: Pirazol, üç karbon atomundan ve yan yana iki azot atomundan oluşan beş üyeli heterosiklik bir halka sistemidir. Literatürde pirazol çekirdeği taşıyan kimyasal bileşiklerin santral sinir sistemi üzerinde önemli bir ... -
Pharmacological and toxicological effects of gas plant (Dictamnus Albus L.)
(2005)Bu çalışmanın amacı Akgiritotu'nun farmakolojik ve toksikolojik etkilerini araştırmaktır. Yaprak ve meyvalarmdan hazırlanan sulu ekstreler kobay derisi üzerinde 2,4-dinitrobenzen ile karşılaştırmalı olarak test edilmiştir. ... -
In the present work, Microsteam distillation - Solid phase microextraction (MSD-SPME) and hydrodistillation (HD) techniques were applied to obtain volatiles from Achillea sivasica, an endemic species from Turkey. GC-FID and GC/MS analysis revealed that 1,8-cineole (22.1%) and ?-pinene (9.3%) were the main constituents of the hydrodistilled flower volatiles. (Z)-?-Farnesene (23.9%), decanoic acid (10.1%), ??eudesmol (8.0%), tricosane (7.3%) and hexadecanoic acid (7.2%) were the main volatiles obtained from flowers by MSDSPME. The leaf volatiles obtained by HD contained camphor (9.0%), ?-pinene (6.9%), 1,8-cineole (6.7%), ?-pinene (6.7%) and??-bisabolol (6.6%) as the main constituents while the leaf volatiles obtained by MSD-SPME technique were rich in (E)-geranyl acetone (10.5%), (E)-?-ionone (10.3%), camphor (10.2%), 1,8-cineole (9.6%), longiverbenone (7.9%), ?-eudesmol (7.5%), isopropyl myristate (6.7%) and epi-?-bisabolol (6.4%). The root volatiles were rich in longiverbeno
(2018)In the present work, Microsteam distillation - Solid phase microextraction (MSD-SPME) and hydrodistillation (HD) techniques were applied to obtain volatiles from Achillea sivasica, an endemic species from Turkey. GC-FID ... -
Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats
(2006)The effects of Hypericum perforatum (St John's wort) on ethanol withdrawal syndrome have been investigated in ethanol-dependent rats. Adult male Wistar rats were subjects. Ethanol (7.2% v/v) was given to rats by a liquid ... -
Extract of Hypericum perforatum blocks nicotine-induced locomotor activity in mice
(2006)In the present study, the effects of Hypericum perforatum on nicotine-induced locomotor activity have been investigated in mice. Adult male Swiss-Webster mice were subjects. Nicotine (0.5, 1 and 2 mg/kg) and saline were ... -
Altered responses to calcium and trifluoperazine in K+-depolarized duodenum from alloxan diabetic rats
(1987)Contractile responses to calcium were examined in the K+-depolarized duodenum from normal and alloxan-diabetic rats. In addition, verapamil and trifluoperazine which are well-known calcium channel blocker and calmodulin ... -
Cytotoxic and inhibitory effects of pomegranate peel extract on proliferation of MCF-7 cells [Nar meyve kabugu ekstresi·ni·n mcf-7 hücre proli·ferasyonu üzeri·ne si·totoksi·k ve i·nhi·bi·tör etki·leri·]
(2008)The Pomegranate (Punica granatum L.) is a wonderful fruit which contains a wide variety of precious phytochemical compounds applicable in the fields of therapeutics and health care. Previous studies have demonstrated the ... -
On the relaxant actions of some benzimidazole derivatives on the rat duodenum: Approaches to the mechanism
(1986)[No abstract available] -
Inhibitory effects of secondary metabolites of halotolerant aspergillus terreus on angiogenesis
(Scientific Publishers of India, 2017)Angiogenesis inhibitors have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. Fungi have been known (as) a wide useful source ... -
Ethnobotany of Eskisehir and its environs
(2013)Eskişehir is located in the Central Anatolian province of Turkey. It is included in B3 grid square of Davis. There are more than 1000 plant taxa distributed in this State and its environs and nearly 220 are endemics. The ...
