Yazar "Levent, Serkan" için listeleme
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Synthesis and Anticandidal Activity of New Imidazole-Chalcones
Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
Karaburun, Ahmet Çağrı; Kaya Çavuşoğlu, Betül; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2019)Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this ... -
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
Turan, Gülhan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Ilgın, Sinem; Hussein, Weiam (Taylor & Francis LTD, 2018)A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a-2o) and their Schiff bases (3a-3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized ... -
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
Hussein, Weiam; Sağlık, Begüm Nurpelin; Levent, Serkan; Korkut, Büsra; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ... -
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
Tok, Fatih; Koçyiğit-Kaymakçıoğlu, Bedia; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2019)In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ... -
Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Karaduman, Abdullah Burak; Kaplancıklı, Zafer Asım (MDPI, 2018)Twenty-six novel thiosemicarbazone derivative B1-B26 were synthesized via condensation reactions between the corresponding thiosemicarbazides and aldehydes. The chemical characterization of the compounds was carried out ... -
Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents
Cevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Karaduma, Abdullah Burak; Kaplanciki, Zafer Asim (Hrvatsko Farmaceutsko Drustov (Hfd)-Croation Pharmaceutical Soc, 2020)The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[5-(substituted amino)-1,3,4-thiadiazol-2-yl)thiolacetamide derivatives and investigation of their anticancer activities were the aims of this work. All the ... -
Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives
Yurttaş, Leyla; Abu Mohsen, Usama; Özkan, Yeşim; Çobanoğlu, Simla; Levent, Serkan; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)In the present paper, a novel series of dibenzofuran-piperazine derivatives were synthesized via the treatment of N-(2-methoxy-3-dibenzofuranyl)-2-chloroacetamide with substituted piperazine derivatives. The chemical ... -
Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents
Cevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Ozkay, Yusuf; Kaplancikl, Zafer Asim (Walter De Gruyter Gmbh, 2020)Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs ... -
Synthesis and characterization of new piperazinedithiocarbamate compounds as potent MAO-A inhibitors
Anadolu Üniversitesi, Eczacılık Fakültesi; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf (Anadolu Üniversitesi, 2022)Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this ... -
Synthesis and docking study of benzimidazole-triazolothiadiazine hybrids as aromatase inhibitors
Cevik, Ulviye Acar; Saglik, Begum N.; Osmaniye, Derya; Levent, Serkan; Cavusoglu, Betul Kaya; Karaduman, Abdullah B.; Kaplancikli, Zafer A. (Wiley-V C H Verlag Gmbh, 2020)Aromatase is involved in the biosynthesis of estrogen and thus is a critical target for breast cancer. in this study, to identify new aromatase enzyme inhibitors, seven 3-[4-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl]-6-( ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
Karaburun, Ahmet Çağrı; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2018)With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ... -
Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
Acar, Çevik, U.; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (HeteroCorporation, 2019)A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ... -
Synthesis and monoamine oxidase A/B inhibitory evaluation of new benzothiazole-thiazolylhydrazine derivatives
Turan, Gulhan; Osmaniye, Derya; Saglik, Begum Nurpelin; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Kaplancikli, Zafer Asim (Taylor & Francis Ltd, 2020)In this study, a novel series of benzothiazole-thiazolylhydrazine (3a-3i) was synthesized and their structures were characterized by H-1-NMR, C-13-NMR spectrometry, and mass spectroscopy. These compounds were evaluated as ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Synthesis of new benzothiazole derivatives bearing thiadiazole as monoamine oxidase inhibitors
Acar Cevik, Ulviye; Osmaniye, Derya; Saglik, Begum N.; Levent, Serkan; K. Cavusoglu, Betul; Karaduman, Abdullah B.; Turan, Gulhan (Wiley, 2020)Monoamine oxidases (MAO) are enzymes that catalyze the oxidative deamination of monoamines such as dopamine, noradrenaline, adrenaline, and serotonin. Recent studies have shown that numerous benzothiazole derivatives exhibit ... -
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; İnci, Beril; Ilgın, Sinem; Kaplancıklı, Zafer Asım (MDPI, 2017)In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ... -
Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors
Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes. Method: Hence, this study was undertaken to synthesize new ... -
Synthesis of novel benzimidazole-oxadiazole derivatives as potent anticancer activity
Cevik, Ulviye Acar; Osmaniye, Derya; Cavusoglu, Betul Kaya; Saglik, Begum Nurpelin; Levent, Serkan; Ilgin, Sinem; Kaplancikli, Zafer Asim (Springer Birkhauser, 2019)DNA topoisomerase I regulates DNA topological structure in many cellular metabolic processes and is a validated target for the development of antitumor agents. in this work, a series of novel 2-[(5-(4-(5(6)-substituted-1 ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
Levent, Serkan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ...