Yazar "Çiftçi, Gülsen Akalın" için listeleme

Activity Guided Fractionation of Arum italicum Miller Tubers and the LC/MS-MS Profiles

Ağalar, Hale Gamze; Çiftçi, Gülsen Akalın; Göğer, Fatih; Kırımer, Neşe (Acg Publications, 2018)

In this study, the polar extract of Arum italicum Miller tubers was fractionated by ` biological activity guided fractionation' method. MCF-7 (human breast adenocarcinoma) and A549 (non-small lung cancer) cancer cell lines ...

Antiinflammatory Consequences of Atorvastatin and Glitazone Therapies on Hypercholesterolemic Rats

Çiftçi, Gülsen Akalın; Erdoğan, I.; Musmul, Ahmet; Alataş, İbrahim Özkan (Birkhauser Verlag Ag, 2011)

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Apoptosis inducing effects of novel benzimidazole derivatives bearing pyridyl/pyrimidinyl piperazine moieties on A549 lung adenocarcinoma

Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yurttaş, Leyla (Wiley-Blackwell, 2016)

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The apoptotic and genomic studies on A549 cell line induced by silver nitrate

Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (SAGE Publications LTD, 2017)

Lung cancer is the leading cause of male cancer deaths worldwide. Metal-based anticancer drugs have evolved significantly during the past decades. Recently, silver ions have been investigated for their anticancer effects. ...

Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines

Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)

In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ...

Biological activity evaluation of new 3,5,6-trisubstituted triazine derivatives bearing different heterocyclic rings against lung cancer cell lines

Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demir, B. (Wiley-Blackwell, 2016)

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Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings

Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Sağlık, Begüm Nurpelin; Demir, Bahar; Levent, Serkan (Bentham Science Publ LTD, 2017)

Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ...

Biotransformation of abietic acid by fungi and biological evaluation of its metabolites

Özşen, Özge; Kıran, İsmail; Dağ, İlknur; Atlı Eklioğlu, Özlem; Çiftçi, Gülsen Akalın; Demirci, Fatih (Elsevier Sci LTD, 2017)

Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite namely 2 alpha-hydroxy-dehydroabietic acid whereas ...

A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells

Çiftçi, Gülsen Akalın; Sever, Belgin; Altıntop, Mehlika Dilek (Turkish Pharmacists Assoc, 2019)

Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ...

The cytotoxic activity of Vitex agnus castus L. essential oils and their biochemical mechanisms

Duymuş, Hale Gamze; Çiftçi, Gülsen Akalın; Yıldırım, S. Ulusoylar; Demirci, Betül; Kırımer, Neşe (Elsevier Science BV, 2014)

In this present study, essential oils from fruit and fruitless herba of Vitex agnus castus L. collected from Izmir, Turkey, were obtained by hydrodistillation using Clevenger-type apparatus for 3 h. The cytotoxic and ...

Cytotoxic, anti-proliferative and apoptotic effects of silver nitrate against H-ras transformed 5RP7

Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (Springer, 2016)

Metal based drugs have successfully been used in both the detection and treatment of different disease states. The antibacterial features of metal ion silver are well documented. Most recently, metal ion silver has been ...

Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines

Yurttaş, Leyla; Demirayak, Şeref; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2015)

Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ...

Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines

Oturanel, Ceren E.; Kıran, İsmail; Özşen, Özge; Çiftçi, Gülsen Akalın; Atlı Eklioğlu, Özlem (Bentham Science Publ LTD, 2017)

Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ...

Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives

Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)

Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ...

Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents

Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet; Altıntop, Mehlika Dilek (Marmara University, 2019)

Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ...

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet (MDPI, 2018)

In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1-10) were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma, and NIH/3T3 ...

Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors

Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)

In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ...