Yazar "Özdemir, Ahmet" için listeleme
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Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways
Can, Özgür Devrim; Alyu, Feyza; Turan, Nazlı; Özdemir, Ahmet (Bentham Science Publ LTD, 2016)This study was planned to investigate possible antinociceptive activity of 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives (2a-s), based on the analgesia-inducing potential of 4,5-dihydro-1H-pyrazole ... -
Bazı İmidazo[1,2-a]pirazin Türevlerinin Sentezi ve Antinosiseptif Aktivitelerinin Değerlendirilmeleri
Amaç: İmidazopirazin halkası biyolojik olarak aktif bir heterosiklik halkadır. Bir dizi hidrazid-hidrazon türevi bileşiğin antibakteryial-antifungal, antikonvülzan, antiinflamatuvar, antitüberkülotik ve analjezik aktiviteye ... -
Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
Sever, Belgin; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Bloomquist, Jeffrey R. (Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
COX inhibitory profiles of a series of thiadiazole-benzothiazole hybrids
Anadolu Üniversitesi; 0000-0003-0280-5550; 0000-0002-5233-1165; Özdemir, Ahmet; Temel, Halide Edip (Anadolu Üniversitesi, 2024)In an endeavour to identify small molecule COX-1 inhibitors, a colorimetric assay protocol was applied for the in vitro evaluation of COX-1 and 2 inhibitory potential of a series of thiadiazole-benzothiazole hybrids. The ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı; 0000-0003-4847-9711; 0000-0001-5098-8967; 0000-0003-0280-5550; 0000-0002-8159-663X; Sever, Belgin; Akalın Çiftçi, Gülşen; Özdemir, Ahmet; Altıntop, Mehlika Dilek (2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Sever, Belgin; Altıntop, Mehlika Dilek; Radwan, M. O.; Özdemir, Ahmet; Otsuka, Masami; Fujita, M.; Çiftçi, H. I. (Elsevier Masson SAS, 2019)Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ... -
Design, synthesis and in vitro COX inhibitory profiles of a new series of tetrazole-based hydrazones
Anadolu Üniversitesi, Eczacılık Fakültesi; Altıntop, Mehlika Dilek; Sever, Belgin; Temel, Halide Edip; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Anadolu Üniversitesi, 2022)Inhibition of cyclooxygenases (COXs), by selective and nonselective inhibitors, is a favorable approach for pharmacologic intervention in a variety of disorders such as cancer. For this purpose, a new class of tetrazole-hydrazone ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet; Altıntop, Mehlika Dilek (Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
Altıntop, Mehlika Dilek; Çiftçi, Halil İbrahim; Radwan, Mohamed O.; Sever, Belgin; Kaplancıklı, Zafer Asım; Ali, Taha F. S.; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ... -
Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1-10) were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma, and NIH/3T3 ... -
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Tilki, Elif Kaya; Dikmen, Miriş (MDPI, 2018)Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Osmaniye, Derya; Sağlık, Begüm Nurpelin, Begüm N.; Özdemir, Ahmet (Wiley-V C H Verlag GMBH, 2018)In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones ... -
Eskişehir Çifteler İlçesinde El Sanatlarının Yaşatılması: Oya Örücülüğü
Ertürk, Nilay; Varol, Esra (2017)El sanatları, bir toplumun kültürel birikiminin, gelenek ve göreneklerinin, tarihinin, gelişiminin, sanatsal ve estetik anlayışının göstergelerinden birisidir. El sanatları konusunda verilen ürünlere göre zengin bir birikime ... -
Eskişehir'de Eczane Teknisyenleri üzerine Bir Araştırma
Bu çalışmada, Eskişehir'deki eczacıların bakış açısından eczane teknisyenlerinin değerlendirilmesi üzerine bir araştırma gerçekleştirilmesi amaçlanmıştır. Metod: Bu çalışmanın eczacıları tesadüfî örnekleme yöntemi ile ... -
Eskişehir’in çekici faktörlerinin günübirlik ziyaretçilerin bakış açılarıyla değerlendirilmesi
Evren, Savaş; Kozak, Nazmi (2012)Bu çalışma, Eskişehir’in çekici faktörlerinin, ilin bir turistik destinasyon olarak tercih edilmesindeki etkilerinin belirlenmesi amacıyla gerçekleştirilmiştir. Eskişehir’e gelen 235 günübirlik ziyaretçi üzerinde yürütülen ... -
Evaluation of antidepressant-like effect of 2-pyrazoline derivatives
Gök, Şule; Demet, M. Murat; Özdemir, Ahmet; Turan, Gülhan (Birkhauser Boston Inc, 2010)Many studies have shown that pyrazoline derivatives have therapeutic potential as antidepressant drugs. In this study, we aimed to investigate the antidepressant-like effect of eight new 1-[(N,N-disubstituted thiocarbamo ... -
Gazetecinin Yıllık Ücretli İzin Hakkı
Oğuz, Özgür; Doğan, Özge (2016)5953 sayılı Basın Mesleğinde Çalışanlarla Çalıştıranlar Arasındaki Münasebetlerin Tanzimi Hakkında Kanun'da basın mesleğinde çalışanların yasal hakları gazetecilik mesleğinin ihtiyaçlarına göre özel olarak ve diğer iş ... -
Genel matematik dersindeki öğrenci başarısı ile öss başarısı arasındaki ilişki
Çetin, Nezahat; Mahir, Nevin (2006)Bu çalışmanın amacı, fen ve mühendislik fakültelerinde okutulan Genel Matematik dersindeki öğrenci başarısı ile ÖSS deki başarıları arasında bir ilişki olup olmadığını ortaya koymaktır. Araştırma, Anadolu Üniversitesi Fen ...
