Yazar "Akalın Çiftçi, Gülsen" için listeleme
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Anticancer Activity of Some Bisbenzimidazoles
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin; Akalın Çiftçi, Gülsen (Verlag Z Naturforsch, 2011)The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some ... -
Apoptotic Effects of Some Thiohydantoin Derivatives
Seller, Zerrin; Akalın Çiftçi, Gülsen (Turkish Biochem Soc, 2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Apoptotic effects of some thiohydantoin derivatives [Bazi{dotless} Tiyohidantoin Türevlerinin Apoptotik Etkileri]
Seller, Zerrin; Akalın Çiftçi, Gülsen (2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Chemical Composition and Biological Activity of Centaurea baseri: New Species from Turkey
Köse, Yavuz Bülent; İşcan, Gökalp; Göğer, Fatih; Akalın Çiftçi, Gülsen; Demirci, Betül; Başer, K. Hüsnü Can (Wiley-V C H Verlag GMBH, 2016)The genus Centaurea L. is one of the largest and important genera of Asteraceae family. Centaurea species have been widely used as herbal remedies in folk medicine for their antidandruff, antidiarrheic, antirheumatic, ... -
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2005)Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ... -
The effects of atorvastatin on antioxidant/antiinfammatory properties of HDLs in hypercholesterolemics
Background/aim: Hypercholesterolemia is characterized by changes in lipid profle, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines [Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Carvacrol is a phenolic monoterpen found in Thyme plant which is used as a source of flavour in food. The aim of this study was to investigate apoptotic effects of carvacrol on H-ras transformed 5RP7 and N-ras transformed ... -
H-ras aktif fibroblast hücre apoptozunun bazı 1,3-bis-(heteroaril substitue) benzen türevleri ile uyarılması
Akalın Çiftçi, Gülsen; Seller, Zerrin (2006)Apoptoz embiryonik gelişim ve doku homeostazın düzenlenmesi esnasında oluşan normal fizyolojik bir olaydır. Günümüzde bazı kemotröpatik ajaların hücre içersinde apoptoz yolaklarını stimüle edebilme yeteneğine sahip olduğu ... -
Novel Tri-substituted Thiazoles Bearing Piperazine Ring: Synthesis and Evaluation of their Anticancer Activity
Evren, Asaf Evrim; Yurttaş, Leyla; Ekselli, Büşra; Akalın Çiftçi, Gülsen (Bentham Science Publ LTD, 2019)Background: Cancer cells are described as an unregulated growth and spread of abnormal cells. Recently, cancer has become the most important major reason for deaths in the world. Methods: For anticancer activity, we have ... -
Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives
Maillard, Ludovic T.; Bertout, Sebastien; QuinÖnero, Ophelie; Akalın Çiftçi, Gülsen; Turan, Gülhanulan; Fulcrand, Pierre; Masurier, Nicolas (Pergamon-Elsevier Science LTD, 2013)Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, ... -
Synthesis and anticandidal activity of new triazolothiadiazine derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; İşcan, Gökalp; Akalın Çiftçi, Gülsen; Yıldırım, Şafak Ulusoylar (Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)New triazolothiadiazine derivatives were synthesized via the ring closure reaction of 4-amino-5-substituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones with phenacyl bromides. The compounds were tested in vitro against various ... -
Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Temel, Halide Edip; Akalın Çiftçi, Gülsen (Wiley-V C H Verlag GMBH, 2012)In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives ... -
Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Benkli, Kadriye; Chevallet, Pierre; Akalın Çiftçi, Gülsen (Elsevier France-Editions Scientifiques Medicales Elsevier, 2008)The increasing clinical importance of drug-resistant mycobacterial pathogens has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new thiazolylhydrazone ... -
Synthesis and biological evaluation of 5-methyl-4-phenyl thiazole derivatives as anticancer agents
Evren, Asaf Evrim; Yurttaş, Leyla; Ekselli, Büsra; Akalın Çiftçi, Gülsen (Taylor & Francis LTD, 2019)New N-(5-methyl-4-phenylthiazol-2-yl)-2-(substituted thio)acetamides were synthesized and studied for their anticancer activity. The title compounds were procured by reacting 2-chloro-N-(5-methyl-4-phenylthiazol-2-yl)acetamide ... -
Synthesis and evaluation of new benzoxazole derivatives as potential antiglioma agents
Altıntop, Mehlika Dilek; Akalın Çiftçi, Gülsen; Edip Temel, Halide (Marmara University, 2018)Gliomas account for the majority of human brain tumors and the incidence of gliomas is expected to rise in upcoming years and therefore extensive efforts have been devoted to the discovery of potent antiglioma agents. Due ... -
Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives
Şüküroğlu, Murat; Onkol, Tijen; Onurdağ, Fatma Kaynak; Akalın Çiftçi, Gülsen; Şahin, M. Fethi (Verlag Z Naturforsch, 2012)New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, H-1 NMR, and MS data. These ...
