Yazar "Atlı Eklioğlu, Özlem" için listeleme
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Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
Perk, Başak Özlem; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Duymuş, Hale Gamze; Sırmagül, Başar (Hindawi Publishing Corporation, 2013)The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study
Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, Nurdan (2013)Bu çalışmada ESOGU Tıp Fakültesi Hastanesi Yetişkin Acil Servisine Ocak 2003 - Aralık 2009 yılları arasında başvuran akut ilaç zehirlenme olgularının retrospektif olarak değerlendirilmesi amaçlanmaktadır. Bu amaçla olgulara ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study [Eskişehirde akut i·laç zehirlenmeleri: Retrospektif bir çahşma]
Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, N.; Uzuncakara, D. (2013)The aim of this study was to characterize acute drug-poisoning cases admitted to the Adult Emergency Service of ESOGU Medicine Faculty Hospital, Turkey. All acute drug-poisoning cases admitted to the emergency service from ... -
Analysis of gender-related differences among the patients with suicidal drug intoxication
Ilgın, Sinem; Saraçoğlu, Ahmet; Atlı Eklioğlu, Özlem; Acar, N. (Elsevier Ireland LTD, 2010)… -
Assessment of the Endothelial Functions in Monocrotaline-induced Pulmonary Hypertension
Sırmagül, Başar; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Usanmaz, Suzan Emel; Demirel-Yılmaz, Emine (Taylor & Francis Inc, 2013)Pulmonary hypertension (PH) is a life-threatening disease that causes endothelial dysfunction in the pulmonary vascular bed. Systemic endothelial dysfunction has also been reported in PH. This study compared the systemic ... -
Assessment of the potential reproductive toxicity of citalopram in male rats
Atlı Eklioğlu, Özlem; Baysal, Merve; Kılıç, G.; Kılıç, Volkan; Uçarcan, Şeyda; Korkut, B.; Ilgın, Sinem (Elsevier Ireland LTD, 2016)… -
Assessment of trazodone-induced cardiotoxicity after repeated doses in rats
Atlı Eklioğlu, Özlem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Gormus, G.; Ucarcan, S.; Ilgın, Sinem (SAGE Publications LTD, 2019)Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting ... -
Biotransformation of abietic acid by fungi and biological evaluation of its metabolites
Özşen, Özge; Kıran, İsmail; Dağ, İlknur; Atlı Eklioğlu, Özlem; Çiftçi, Gülsen Akalın; Demirci, Fatih (Elsevier Sci LTD, 2017)Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite namely 2 alpha-hydroxy-dehydroabietic acid whereas ... -
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Citalopram Induces Reproductive Toxicity in Male Rats
Ilgın, Sinem; Aydoğan-Kılıc, G.; Baysal, Merve; Kılıç, Volkan; Korkut, Büşra; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Wiley, 2017)Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
Oturanel, Ceren E.; Kıran, İsmail; Özşen, Özge; Çiftçi, Gülsen Akalın; Atlı Eklioğlu, Özlem (Bentham Science Publ LTD, 2017)Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ... -
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines ... -
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines
Özkay, Ümide Demir; Can, Özgür Devrim; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2016)In the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (AChE) inhibitors. The target compounds were synthesised in three steps. Structures ... -
Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)A series of 2-(4-substitutedmethylphenyl) propionic acid derivatives (6a-6m) were synthesized, characterized and evaluated for cyclooxygenase (COX) enzyme inhibitory and antimicrobial activity. Test compounds that exhibited ... -
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: A retrospective study
Sırmagül, B.; Atlı Eklioğlu, Özlem; Ilgın, Sinem (SAGE Publications LTD, 2012)The present study aimed at determining the differences in plasma concentrations of traditional antiepileptics such as phenytoin, carbamazepine, and valproic acid in patients receiving monotherapy and combination therapy. ... -
The effect of polytherapy on serum concentrations of traditional antiepileptics: A retrospective study
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Sırmagül, Başar (Elsevier Ireland LTD, 2011)… -
Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats
Ilgın, Sinem; Burukoğlu, Dilek; Atlı Eklioğlu, Özlem; Sırmagül, Başar (Humana Press Inc, 2012)In our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure ... -
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
Bal, E.; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Ergün, Bülent; Sırmagül, Başar (SAGE Publications LTD, 2013)The present study aimed to compare the effect of gender difference on hemodynamic consequences in the development of monocrotaline (MCT)-induced pulmonary hypertension in rat. The effect of antioxidant enzyme systems on ... -
Evaluation of azithromycin induced cardiotoxicity in rats
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Altuntaş, Hakan; Burukoğlu, Dilek (E-Century Publishing Corp, 2015)Although there are possible cardiovascular adverse effects associated with the azithromycin treatment according to some case reports and cohort studies, there is no experimental study evaluating cardiotoxicity in repeated ...
