Yazar "Avan, İlker" için listeleme
-
Bazı indol bileşikleri üzerine kimyasal çalışmalar
Avan, İlker (Anadolu Üniversitesi, 2006)Bu çalışmada çeşitli 3,4-dihidro-4-okso-5H-piridazino[4,5-b]indol, 1-amino-3,4-dihidro-4-okso-5Hpiridazino[4,5-b]indol, 4-amino-1,2-dihidro-1-okso5H-piridazino[4,5-b]indol türevleri, 1-hidrazino-3,4-dihidro-1-okso-5H-pir ... -
Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters
Avan, İlker; Tala, Srinivasa R.; Steel, Peter J.; Katritzky, Alan R. (American Chemical Society, 2011)Reactions of O-Pg(alpha-hydroxyacyl)benzotriazoles with (a) unprotected alpha-hydroxycarboxylic acids, (b) amino acids, and (c) amines afforded, respectively, chirally pure (a) oligoesters, (b) depsidipeptides, and (c) ... -
Benzotriazole-Mediated Synthesis of Aza-peptides: En Route to an Aza-Leuenkephalin Analogue
Abo-Dya, Nader E.; Biswas, Suvendu; Başak, Akash; Avan, İlker; Alamry, Khalid A.; Katritzky, Alan R. (American Chemical Society, 2013)Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with alpha-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide 23b, and alpha-hydroxy-beta-phenylpropionic acid 27 yielding, ... -
Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41
Jiang, Shibo; Tala, Srinivasa R.; Lu, Hong; Zou, Peng; Avan, İlker; İbrahim, Tarek S.; Katritzky, Alan R. (Pergamon-Elsevier Science LTD, 2011)Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a-h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki-Miyaura cross coupling, followed by ... -
Design, Synthesis, and Biological Activity of Novel 5-((Arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 Fusion Inhibitors Targeting gp41
Jiang, Shibo; Tala, Srinivasa R.; Lu, Hong; Abo-Dya, Nader E.; Avan, İlker; Gyanda, Kapil; Debnath, Asım K. (American Chemical Society, 2011)On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds ... -
Efficient preparation of aminoxyacyl amides, aminoxy hybrid peptides and a-aminoxy peptides
Tala, Srinivasa R.; Avan, İlker; Katritzky, Alan R. (American Chemical Society, 2010)… -
Efficient Preparation of Aminoxyacyl Amides, Aminoxy Hybrid Peptides, and alpha-Aminoxy Peptides
Katritzky, Alan R.; Avan, İlker; Tala, Srinivasa R. (American Chemical Society, 2009)N-(Pg-alpha-aminoxy acids) 1a-g are converted to N-(Pg-alpha-aminoxyacyl)benzotriazoles 2a-g, Which react under mild conditions with amines, alpha-amino acids/alpha-dipeptides, and alpha-aminoxy acids to give aminoxyacyl ... -
Microwave-Assisted Synthesis of 2,2 '-Azopyridine-Labeled Amines, Amino Acids, and Peptides
Avan, İlker (Georg Thieme Verlag Kg, 2016)A microwave-assisted procedure for labeling amines, amino acids, and peptides with 2,2'-azopyridines (2,2'-AzPy) is described using the corresponding 2,2'-azopyridine-diacylbenzotriazoles. The efficiency of the procedure ... -
Peptidomimetics via modifications of amino acids and peptide bonds
Avan, İlker; Hall, C. Dennis; Katritzky, Alan R. (Royal Soc Chemistry, 2014)Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, ... -
Photophysics of novel coumarin-labeled depsipeptides in solution: sensing interactions with SDS micelle via TICT model
Biswas, Suvendu; Avan, İlker; Başak, Akash; Abo-Dya, Nader E.; Asiri, Abdullah; Katritzky, Alan R. (Springer Wien, 2013)N-Acylbenzotriazoles enable the synthesis (69-92 % yield) of blue to green fluorescent coumarin-labeled depsidipeptides 8a-f (quantum yields 0.004-0.97) and depsitripeptides 12a-d (quantum yields 0.02-0.96). Detailed ... -
Removal of copper(II) and nickel(II) ions from aqueous solution using non-living lichen Ramalina fraxinea biomass: investigation of kinetics and sorption isotherms
Candan, Mehmet; Tay, Funda; Avan, İlker; Tay, Turgay (Desalination Publ, 2017)Studies in the field of heavy metal ion removal from industrial wastewater using biomass are increasing in number due to highly efficient and cost-effective applications. In this study, we report the use of non-living ... -
Some applications of benzotriazole compounds in synthetic chemistry
Avan, İlker (Anadolu Üniversitesi, 2012)Peptit ve peptit benzeri yapıların (peptidomimetikler) tedavi edici uygulamaları son zamanlarda farmakolojik bilim dallarında büyük ilgi uyandırmıştır. Bu tez çalışmasında, depsipeptitler, ?-aminoksipeptitler ve onların ... -
Synthesis and antimicrobial investigation of some 5H-pyridazino[4,5-b] indoles
Avan, İlker; Güven, Alaattin; Güven, Kıymet (2013)Synthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro- 5H -pyridazino[4,5- b]indole derivatives. Corresponding pyridazino[4,5- b]indoles were prepared from ethyl ... -
Synthesis and antimicrobial investigation of some 5H-pyridazino[4,5-b]indoles
Avan, İlker; Güven, Alaattin; Güven, Kıymet (Scientific Technical Research Council Turkey-Tubitak, 2013)Synthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indole derivatives. Corresponding pyridazino[4,5-b]indoles were prepared from ethyl ...
