Yazar "Büyükköroğlu, Gülay" için listeleme
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Breast cancer gene therapy
Büyükköroğlu, Gülay; Abbasoğlu, Duygu; Hızel, C.; Büyükköroğlu, Gülay; Abbasoğlu, Duygu; Hızel, Candan (Springer India, 2014)Breast cancer, one of the most common female malignancy around the world, is a major public health problem. It is estimated that 1 woman in 9 will develop breast cancer during her lifetime. Conventional therapies, such as ... -
Chitosan nanoparticles for ocular delivery of cyclosporine A
Başaran, Ebru; Yenilmez, Evrim; Berkman, Murat Sami; Büyükköroğlu, Gülay; Yazan, Yasemin (Taylor & Francis LTD, 2014)In the present study, cyclosporine A (CsA) was successfully incorporated into cationic chitosan nanoparticles by spray-drying method aiming ocular application. Physicochemical characterisation of particles was performed ... -
Development and evaluation of a cosmetic W/O emulsion system containing a model plant extract
Bu çalışmada, bitkisel bir madde olan Centaurium erythraea’nin s/y tipi emülsiyon sistemi içindeki fizikokimyasal ve kozmetik değerlendirmesi yapılmıştır. Centaurium erythraea’nin yapraklarından elde edilen %2 ve %4’lük ... -
Development of paclitaxel-loaded liposomal systems with anti-her2 antibody for targeted therapy
Büyükköroğlu, Gülay; Şenel, Behiye; Başaran, Ebru; Gezgin, Seval (Pharmacotherapy Group, 2016)Purpose: To develop liposome formulations containing monoclonal antibody anti-HER2 (MabHer2), and Paclitaxel (PTX). Methods: Seven different liposomal systems containing PTX, or MabHer2 or a combination of PTX and MabHer2 ... -
Development of Solid Lipid Gene Delivery System
Büyükköroğlu, Gülay (2016)Rekombinant DNA teknolojisindeki ilerlemelerin doğal sonucu olarak, kalıtsal hastalıkların iyileştirilmesi için gen tedavisi gündeme gelmiştir. Gen tedavisinde amaç, vücuttan alınan hücreler içinde yeni genetik materyalin ... -
Development of solid lipid gene delivery system [Katı lipit gen taşıyıcı sistem geliştirilmesi]
Büyükköroğlu, Gülay (Turkish Pharmacists Association, 2016)As a natural result of the progresses made in the recombinant DNA technology, the gene treatment has been brought forward for the improvement of genetic disorders. The purpose of the gene therapy is the treatment of the ... -
Engineering Monoclonal Antibodies: Production and Applications
Büyükköroğlu, Gülay; Şenel, Behiye (Academic Press LTD-Elsevier Science LTD, 2018)… -
Farmasötik amaç için kullanılacak mikro- ve nanopartiküllere antikor bağlama ve etkinliklerinin araştırılması
Gezgin, Seval (Anadolu Üniversitesi, 2013)Kanser hücreleri, yok edilmelerine neden olabilecek doğal ve yapay girişimleri, varlıklarının devamı için yönetebilirler. Tıbbın kanserle savaşma yöntemlerini elimine etmek ve hastanın immün sistemini kandırmak için çok ... -
Farmasötik biyoteknoloji'de gen tedavisi amaçlı plazmit DNA taşıyıcı katyonik katı-lipit nano-veya mikropartiküllerin hazırlanması çalışmaları
Büyükköroğlu, Gülay (Anadolu Üniversitesi, 2005)Büyük DNA molekülleri, yalnızca katyonik lipit ve polimerler gibi sentetik vektörler kullanılarak hücre içine sokulabilmektedir. DNA-katyonik lipit partikülleri genellikle pozitif yüklüdür ve negatif yüklü biyolojik ... -
Formulation and In Vitro Evaluation of Moxifloxacin Hydrochloride-Loaded Polymeric Nanoparticles for Ocular Application
Yurtdaş Kırımlıoğlu, Gülsel; Özer, Sinan; Büyükköroğlu, Gülay; Yazan, Yasemin (Colegio Farmaceuticos Provincia De Buenos Aires, 2018)The primary purpose of this study was to extend the time of interaction of the carrier with the negatively charged ocular surface for enhanced penetration in order to improve ocular bioavailability. Moxifloxacin hydrochloride ... -
Gen taşıyıcı sistem olarak HDL (yüksek-yoğunluk lipoprotein) mikro-ve nanopartküllerinin hazırlanması
Büyükköroğlu, Gülay; Anadolu Üniversitesi, Fen Bilimleri Enstitüsü, İleri Teknolojiler Anabilim Dalı; Masimov, Rasim (2019)Günümüzde Nanoteknoloji ve Gen tedavisinin hızla gelişmesi geleneksel ilaçların yerini, bu sistemler ile oluşturulan, yeni terapötiklere bırakmasına neden olmaktadır. Nanoteknoloji yöntemleri kullanılarak oluşturulan ... -
Graphene quantum dots: Synthesis, characterization, cell viability, genotoxicity for biomedical applications
Şenel, Behiye; Demir, Neslihan; Büyükköroğlu, Gülay; Yıldız, Mustafa (Elsevier, 2019)We report the synthesis and applications of a novel N-doped graphene quantum dots (GQDs) using hydrothermal reaction between citric acid and p-aminophenol. The synthesized N-doped GQDs have been characterized physico-chemically ... -
Meis protein inhibitörü yüklü albümin nanopartiküllerini ve iRGD peptidini içeren in situ jelleşen sistemin hazırlanması ve karakterizasyonu
Büyükköroğlu, Gülay; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmasötik Teknolojisi Anabilim Dalı; Değer, Gizem (Anadolu Üniversitesi -Sağlık Bilimleri Enstitüsü, 2021)Pankreasın duktal adenokarsinomu (PDAC), fibrotik dokunun tümörü çevrelediği bir stromal bariyer ile karakterizedir. Bu bariyer, PDAC'li bireylere uygulanan kemoterapötik ajanların tümör hücrelerine erişimi kısıtlar. Stromal ... -
Preparation and In Vitro Evaluation of DNA-Bonded Polymeric Nanoparticles as New Approach for Transcutaneous Vaccination
Büyükköroğlu, Gülay; Şenel, Behiye; Karabacak, Rukiye B. (Colegio Farmaceuticos Provincia De Buenos Aires, 2017)The objective of this study was to develop a DNA vaccine, which can be applied topically as a cream containing plasmid DNA (pDNA)/cationic polymeric nanoparticle (PP) complex. The selected pDNA was pCMV-S encoding hepatitis ... -
Preparation and in vitro evaluation of DNA-bonded polymeric nanoparticles as new approach for transcutaneous vaccination
Büyükköroğlu, Gülay; Şenel, Behiye; Karabacak, Rukiye B. (Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2017)The objective of this study was to develop a DNA vaccine, which can be applied topically as a cream containing plasmid DNA (pDNA)/cationic polymeric nanoparticle (PP) complex. The selected pDNA was pCMV-S encoding hepatitis ... -
Preparation and in vitro evaluation of vaginal formulations including siRNA and paclitaxel-loaded SLNs for cervical cancer
Büyükköroğlu, Gülay; Şenel, Behiye; Başaran, Ebru; Yenilmez, Evrim; Yazan, Yasemin (Elsevier Science BV, 2016)Cervical cancer is one of the most life threatening types of cancer among women and is generally resistant to chemotherapy. The objective of this study was to prepare a vaginal suppository containing a chemotherapeutic ... -
Preparation and physicochemical characterizations of solid lipid nanoparticles containing DOTAP for DNA delivery
Büyükköroğlu, Gülay; Yazan, Emine Yasemin; Öner, Ayşe Filiz (Scientific Technical Research Council Turkey-Tubitak, 2015)The aim of this study was to prepare and evaluate stable cationic solid lipid nanoparticles (SLNs) as colloidal carriers for gene therapy. SLNs were mainly composed of three different biocompatible and biodegradable matrix ... -
Preparation and physicochemical characterizations of solid lipid nanoparticles containing DOTAP?R for DNA delivery
The aim of this study was to prepare and evaluate stable cationic solid lipid nanoparticles (SLNs) as colloidal carriers for gene therapy. SLNs were mainly composed of three different biocompatible and biodegradable matrix ... -
The simultaneous delivery of paclitaxel and Herceptin (R) using solid lipid nanoparticles: In vitro evaluation
Büyükköroğlu, Gülay; Şenel, Behiye; Gezgin, Seval; Tan Dinh (Elsevier Science BV, 2016)This study was aimed at formulating Paclitaxel (R)-loaded solid lipid nanoparticles (SLN) complexed with Herceptin (R). The physicochemical characterizations of the SLNs/Herceptin (R) complexes such as particle size and ... -
Techniques for Protein Analysis
Büyükköroğlu, Gülay; Dora, Devrim Demir; Özdemir, Filiz; Hızel, Candan (Academic Press LTD-Elsevier Science LTD, 2018)…
