Yazar "Baysal, Merve" için listeleme
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Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
Turan, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Assessment of the potential reproductive toxicity of citalopram in male rats
Atlı Eklioğlu, Özlem; Baysal, Merve; Kılıç, G.; Kılıç, Volkan; Uçarcan, Şeyda; Korkut, B.; Ilgın, Sinem (Elsevier Ireland LTD, 2016)… -
Assessment of trazodone-induced cardiotoxicity after repeated doses in rats
Atlı Eklioğlu, Özlem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Gormus, G.; Ucarcan, S.; Ilgın, Sinem (SAGE Publications LTD, 2019)Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting ... -
Bazı ferula uçucu yağlarının kimyasal bileşimi, biyolojik aktivite, in vitro sitotoksisite ve genotoksisite yönünden incelenmesi
Baysal, Merve (Anadolu Üniversitesi, 2015)Günümüzde doğal kaynaklı ürünlere ilginin artmasıyla bilimsel alanda bu yöndeki çalışmalar da hız kazanmıştır. Uçucu yağlar, eski çağlardan günümüze kadar kullanılagelen aromatik sıvılardır. Koku, tat maddesi olarak ... -
Citalopram Induces Reproductive Toxicity in Male Rats
Ilgın, Sinem; Aydoğan-Kılıc, G.; Baysal, Merve; Kılıç, Volkan; Korkut, Büşra; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Wiley, 2017)Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
Kaya, Betül; Hussin, Weiam; Yurttaş, Leyla; Turan, Gülhan; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Evaluation of hepatotoxicity associated with citalopram administration in rats
Baysal, Merve; Atlı Eklioğlu, Özlem; Dagasan, F.; Burukoğlu, D.; Ilgın, Sinem (Elsevier Ireland LTD, 2015)… -
Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new
Anadolu Üniversitesi; 0009-0003-0969-0474; 0000-0001-7331-1975; 0000-0002-3646-7935; 0000-0002-8099-0942; 0000-0002-0434-1334; 0000-0002-6131-3399; Farmanlı, Gülnar; Ilgın, Sinem; Ergun, Bülent; Baysal, Merve; Karaduman, Abdullah Burak; Atlı Eklioğlu, Özlem (Anadolu Üniversitesi, 2023)Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the ... -
Evaluation of quetiapine-induced hepatotoxicity in rats
Ilgın, Sinem; Atlı Eklioğlu, Özlem; Burukoğlu, Dilek; Baysal, Merve; Hinis, O. (Elsevier Ireland LTD, 2015)… -
Evaluation of the reproductive toxicity of levetiracetam in male rats
Baysal, Merve; Ilgın, Sinem; Kılıç, Volkan; Kılıç, G.; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Elsevier Ireland LTD, 2016)… -
Evidence for cardiotoxicity associated with sertraline in rats
Ilgın, Sinem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Uçarcan, Şeyda; Dermenci, Begüm; Atlı Eklioğlu, Özlem (Royal Soc Chemistry, 2018)Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of ... -
Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
Turan, Gülhan; Hussein, Weiam; Sağlık, Begüm Nurpelin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Reproductive toxic effects and possible mechanisms of zonisamide in male rats
Karaduman, A. B.; Kılıç, Volkan; Atli-Eklioğlu, O.; Baysal, Merve; Aydoğan Kılıç, Gözde; Ucarcan, S.; Ilgın, Sinem (SAGE Publications Ltd, 2019)Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. ... -
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
Baysal, Merve; Ilgın, Sinem; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Public Library Science, 2017)Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of ... -
A Series of Furan-based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity
Altintop, Mehlika Dilek; Sever, Belgin; Eklioglu, Ozlem Atli; Baysal, Merve; Demirel, Rasime; Ozdemir, Ahmet (Bentham Science Publ Ltd, 2020)Background: Hydrazones, frequently occurring motifs in many bioactive molecules, have attracted a great deal of interest as potent antimicrobial agents. Objective: the aim of this work was to design and synthesize new ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
Atlı Eklioğlu, Özlem; Baysal, Merve; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Karaduman, Abdullah Burak; Ilgın, Sinem (Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Sever, Belgin; Baysal, Merve; Temel, Halide Edip; Özdemir, Ahmet (Bentham Science Publ LTD, 2017)Background: In recent years, the relationship between overexpression of matrix metalloproteinases ( MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs. Objective: The ... -
Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Temel, Halide Edip; Atlı Eklioğlu, Özlem; Baysal, Merve; Demirci, Fatih (MDPI, 2017)Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic ...
