Yazar "Beydemir, Sukru" için listeleme
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AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress
Isik, Mesut; Beydemir, Sukru (Taylor & Francis Ltd, 9999)Oxidative metabolic reactions and their by products have played a role in coronary artery disease (CAD) and Alzheimer's disease (AD) pathogenesis. This study was carried out on 28 patients with AD, 21 patients with CAD, ... -
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Isik, Mesut; Beydemir, Sukru; Demir, Yeliz; Durgun, Mustafa; Turkes, Cuneyt; Nasir, Abdul; Akkus, Musa (Elsevier, 2020)Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as antimicrobial drugs for a long time. in the present study, we investigated in vitro inhibitory activities of benzenesulfonamide derivatives ... -
Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes
Turkes, Cuneyt; Demir, Yeliz; Beydemir, Sukru (Taylor & Francis Inc, 9999)Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human erythrocytes using the simple chromatographic method ... -
In Vitro and in Silico Studies on the Toxic Effects of Antibacterial Drugs as Human Serum Paraoxonase 1 Inhibitor
Turkes, Cuneyt; Beydemir, Sukru; Kufrevioglu, Omer Irfan (Wiley-V C H Verlag Gmbh, 2019)The core purpose of the current study was to investigate the interactions of widely used broad-spectrum antibacterial drugs developed in response to the increasing rate of antibiotic-resistant various bacteria and to ... -
The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and alpha-Glycosidase: a Perspective for Metabolic Disorders
Demir, Yeliz; Duran, Hatice Esra; Durmaz, Lokman; Taslimi, Parham; Beydemir, Sukru; Gulcin, Ilhami (Springer, 2020)Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. the management of chronic pain is particularly challenging. For pain ... -
Inhibition effects of some pesticides and heavy metals on carbonic anhydrase enzyme activity purified from horse mackerel (Trachurus trachurus) gill tissues
Caglayan, Cuneyt; Taslimi, Parham; Turk, Cebrahil; Gulcin, Ilhami; Kandemir, Fatih Mehmet; Demir, Yeliz; Beydemir, Sukru (Springer Heidelberg, 2020)The gill tissue is the main site of metabolic enzymes or compensation, with the kidney tissue playing a supporting role. At the gill tissue, carbonic anhydrase enzymes (CAs) catalyze the hydration of CO2 to HCO3- and H+ ... -
Molecular docking and investigation of 4-(benzylideneamino)- and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors
Isik, Mesut; Demir, Yeliz; Durgun, Mustafa; Turkes, Cuneyt; Necip, Adem; Beydemir, Sukru (Springer International Publishing Ag, 2020)The discovery of acetylcholinesterase inhibitors is important for the treatment of Alzheimer's disease (AD), known as the most common type of dementia. Due to the side effects of commonly used acetylcholinesterase inhibitors, ... -
New Isoindole-1,3-dione Substituted Sulfonamides as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase: Design, Synthesis, and Biological Evaluation
Gundogdu, Saliha; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Beydemir, Sukru (Wiley-V C H Verlag Gmbh, 2019)Herein, a series of isoindole-1,3-dione substituted sulfonamide derivatives (3, 4a-k) were designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) and acetylcholinesterase (AChE). CA and ... -
Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors
Istrefi, Qendresa; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Nixha, Arleta R.; Beydemir, Sukru; Kufrevioglu, Omer, I (Wiley-V C H Verlag Gmbh, 2020)In this study, 15 novel compounds in a series of sulfonamide-based ketenes (7a-o) were synthesized and characterized using Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. ... -
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
Isik, Mesut; Akocak, Suleyman; Lolak, Nabih; Taslimi, Parham; Turkes, Cuneyt; Gulcin, Ilhami; Beydemir, Sukru (Wiley-V C H Verlag Gmbh, 9999)In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their ... -
Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, ?-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs
Lolak, Nebih; Akocak, Suleyman; Turkes, Cuneyt; Taslimi, Parham; Isik, Mesut; Beydemir, Sukru; Durgun, Mustafa (Academic Press Inc Elsevier Science, 2020)…
