Yazar "Cevik, Ulviye Acar" için listeleme
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Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer's disease
Cevik, Ulviye Acar; Osmaniye, Derya; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Levent, Serkan; Karaduman, Abdullah Burak; Turan, Gulhan (Springer Birkhauser, 2020)Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several ... -
Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents
Cevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Karaduma, Abdullah Burak; Kaplanciki, Zafer Asim (Hrvatsko Farmaceutsko Drustov (Hfd)-Croation Pharmaceutical Soc, 2020)The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[5-(substituted amino)-1,3,4-thiadiazol-2-yl)thiolacetamide derivatives and investigation of their anticancer activities were the aims of this work. All the ... -
Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents
Cevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Ozkay, Yusuf; Kaplancikl, Zafer Asim (Walter De Gruyter Gmbh, 2020)Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs ... -
Synthesis and docking study of benzimidazole-triazolothiadiazine hybrids as aromatase inhibitors
Cevik, Ulviye Acar; Saglik, Begum N.; Osmaniye, Derya; Levent, Serkan; Cavusoglu, Betul Kaya; Karaduman, Abdullah B.; Kaplancikli, Zafer A. (Wiley-V C H Verlag Gmbh, 2020)Aromatase is involved in the biosynthesis of estrogen and thus is a critical target for breast cancer. in this study, to identify new aromatase enzyme inhibitors, seven 3-[4-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl]-6-( ... -
Synthesis and monoamine oxidase A/B inhibitory evaluation of new benzothiazole-thiazolylhydrazine derivatives
Turan, Gulhan; Osmaniye, Derya; Saglik, Begum Nurpelin; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Kaplancikli, Zafer Asim (Taylor & Francis Ltd, 2020)In this study, a novel series of benzothiazole-thiazolylhydrazine (3a-3i) was synthesized and their structures were characterized by H-1-NMR, C-13-NMR spectrometry, and mass spectroscopy. These compounds were evaluated as ... -
Synthesis of novel benzimidazole-oxadiazole derivatives as potent anticancer activity
Cevik, Ulviye Acar; Osmaniye, Derya; Cavusoglu, Betul Kaya; Saglik, Begum Nurpelin; Levent, Serkan; Ilgin, Sinem; Kaplancikli, Zafer Asim (Springer Birkhauser, 2019)DNA topoisomerase I regulates DNA topological structure in many cellular metabolic processes and is a validated target for the development of antitumor agents. in this work, a series of novel 2-[(5-(4-(5(6)-substituted-1 ... -
Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate
Saglik, Begum Nurpelin; Osmaniye, Derya; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Buyukemir, Oya; Kaplancikli, Zafer Asim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. the IC50 and Ki values of the compounds ... -
Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
Cevik, Ulviye Acar; Cavusoglu, Betuel Kaya; Saglik, Beguem Nurpelin; Osmaniye, Derya; Levent, Serkan; Ilgin, Sinem; Kaplancikli, Zafer Asim (Mdpi, 2020)In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. in this ...
