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Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion
Bektur, Ezgi; Şahin, Erhan; Ceyhan, Emre; Dönmez, Dilek Burukoğlu; Canbek, Mediha; Baycu, Cengiz; Can, Özgür Devrim (Taylor & Francis LTD, 2019)Objectives: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids ... -
Mirtazapin Diyabet Oluşturulan Sıçanların Beyinciklerindeki Hasarı Kısmen Düzeltmektedir
Diabetes mellitus (DM) sistemik bir hastalık olup çeşitli organlarda hasara neden olmaktadır. Bu organlar arasında beyincik de yer almaktadır. Mirtazapin ise majör depresyon tedavisinde kullanılan bir antidepresan madde ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
Şahin, Erhan; Bektur, Ezgi; Dönmez, Dilek Burukoğlu; Baycu, Cengiz; Can, Özgür Devrim; Şahintürk, Varol (Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
Resveratrol reduces IL-6 and VEGF secretion from co-cultured A549 lung cancer cells and adipose-derived mesenchymal stem cells
Şahin, Erhan; Baycu, Cengiz; Koparal, Ayşe Tansu; Dönmez, Dilek Burukoğlu; Bektur, Ezgi (SAGE Publications LTD, 2016)Stem cell therapies are important treatment methodologies used in many areas of experimental or clinical medicine. In recent studies of cancer models, Mesenchymal stem cells (MSCs) suppressed the growth of cancer cells. ...