Yazar "Demirel, Müzeyyen" için listeleme
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Ağızda dağılabilir tablet formülasyonlarının geliştirilmesi ve farmasötik kalite kontrolleri
Kozan, Mustafa (Anadolu Üniversitesi - Sağlık Bilimleri Enstitüsü, 2022)Ketiapin, şizofreni ve bipolar bozukluk tedavisinde kullanılan atipik antipsikotik bir etkin maddedir. Piyasada ketiapin fumarat tuzu halinde bulunmaktadır. Ketiapin fumarat yüksek permeabilite ve düşük çözünürlük ile ... -
Bioavailability file: Piribedil [Biyoyararlanim dosyasi: Piribedil]
Demirel, Müzeyyen; Yazan, Yasemin (2001)Piribedil is a dopamin agonist with vasodilator activity and whose aqueous solubility is low and elimination half-life is short. It is widely used in cerebral ageing and in Parkinson's disease. Literature on physico-chemical ... -
Characterization and Antioxidant Activity of Quercetin/Methyl-beta-Cyclodextrin Complexes
Güleç, Kadri; Demirel, Müzeyyen (Bentham Science Publ LTD, 2016)Quercetin (Qu), a polyphenolic flavonoid, is one of the most effective plant originated antioxidants. Despite the potential use of Qu in clinical trials, low water solubility, stability problems and the scarcity of cellular ... -
Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery
Başaran, Ebru; Demirel, Müzeyyen; Sırmagül, Başar; Yazan, Yasemin (Taylor & Francis LTD, 2010)In the present study, Cyclosporine A (CsA) was successfully incorporated into cationic solid lipid nanoparticles (SLN) for ocular application. Physicochemical characterizations of SLNs were analysed in detail during the ... -
Enhanced bioavailability of cinnarizine using solid dispersion: In vitro and in vivo evaluation
Demirel, Müzeyyen; Büyükköroğlu, G.; Sırmagül, Başar; Kalava, B. S.; Öztürk, Nilgün; Yazan, Yasemin (Bentham Science Publishers B.V., 2015)The aim of this study was to modify the release and thus enhance the bioavailability of acalcium antagonist cinnarizine whose aqueouse solubility is low and half-life is short. For this purpose, solid dispersion system was ... -
Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin
Demirel, Müzeyyen; Büyükköroğlu, G; Kalava, BS; Yazan, Yasemin (Prous Science, Sa, 2006)The aim of this was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare ... -
Flukonazol ve ketokonazol'ün ?-siklodekstrin ile hazırlanan kompleksleri üzerinde yapılan çalışmalar
Yurtdaş, Gülsel (Anadolu Üniversitesi, 2010)Flukonazol (FZ) ve ketokonazol (KZ), mikotik enfeksiyonların tedavisinde yaygın olarak kullanılan azol türevi antifungal farmasötik etkin maddelerdir. Her iki etkin maddenin de sudaki çözünürlüğü düşüktür. Doygunluk ... -
Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles
Demirel, Müzeyyen; Yazan, Yasemin; Muller, RH; Kılıç, F; Bozan, B (Taylor & Francis LTD, 2001)Modification of the dissolution rate and, thus, the enhancement of the bioavailability of a dopaminergic drug, piribedil, which has a low aqueous solubility and short elimination half-life have been the aim in this study. ... -
Formulation and in vitro-in vivo evaluation of rosuvastatin calcium incorporated cyclodextrin, solid lipid and chitosan based drug delivery system
Al-Heibshy, Fawaz Nasser Shekh (Anadolu Üniversitesi, 2017)Kardiyovasküler rahatsızlıklar dünya çapında ölüm nedenlerinin ilk sırasında yer almaktadır. Kardiyovasküler rahatsızlıkların tedavisinde kullanılan pek çok etkin madde, sudaki düşük çözünürlükleri nedeni ile düşük ... -
Inclusion complexes of fluconazole with beta-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation
Yurtdaş Kırımlıoğlu, Gülsel; Demirel, Müzeyyen; Genç, Lütfi (Springer, 2011)Fluconazole (FZ) is a triazole antifungal drug administered orally or intravenously. It is employed for the treatment of mycotic infections. However, the efficacy of FZ is limited with its poor aqueous solubility and low ... -
Inclusion complexes of ketoconazole with beta-cyclodextrin: physicochemical characterization and in vitro dissolution behaviour of its vaginal suppositories
Demirel, Müzeyyen; Yurtdaş Kırımlıoğlu, Gülsel; Genç, Lütfi (Springer, 2011)Ketoconazole (KZ) is an imidazole antifungal agent which is administered topically and also orally. KZ is practically insoluble in water. Vaginal candidiasis is a common condition and up to 75% of all women have at least ... -
Kuersetin'in siklodekstrin nanopartiküllerinin hazırlanması ve in vitro değerlendirilmesi
Güleç, Kadri (Anadolu Üniversitesi, 2016)Polifenolik bir flavonoid olan kuersetin (Qu), bitki orijinli antioksidanların en etkililerinden biridir. Klinik denemelerde potansiyel kullanımı olmasına rağmen, kararlılık problemleri, sudaki çözünürlüğünün ve ... -
Microencapsulation of ketorolac tromethamine by means of a coacervation phase separation technique induced by the addition of non-solvent
Genç, Lütfi; Demirel, Müzeyyen; Güler, E; Hegazy, N (Taylor & Francis LTD, 1998)Ketorolac tromethamine (KT) is a non-steroidal drug with potent analgesic and anti-inflammatory activity and is absorbed rapidly (T-max (1.0h) with an efficiency >87% following oral and intramuscular administration. The ... -
Physicochemical characterization and dissolution properties of cinnarizine solid dispersions
Sudaki çözünürlüğü düşük olarak bilinen kalsiyum antagonisti sinnarizinin biyoyararlanımı değişken veya düşüktür. Bu özellikteki bir ilaç materyalinin çözünme davranışının iyileştirilmesi, oral biyoyararlanımı geliştirebilir. ... -
Piribedil katı lipit partiküllerinin formülasyonu ve in vitro-in vivo değerlendirilmesi
Demirel, Müzeyyen (Anadolu Üniversitesi, 1999)Bu çalışmada, suda çözünürlüğü düşük ve kısa eliminasyon yarı ömre sahip dopaminerjik bir etkin madde olan piribedil'in, salım hızını modifiye etmek ve doalyısıyla biyoyararlanımı arttırmak amaçlanmıştır. Bu amaçla, katı ... -
Polymeric Cyclosporine-A Nanoparticles for Ocular Application
Başaran, Ebru; Demirel, Müzeyyen; Sırmagül, Başar; Yazan, Yasemin (Amer Scientific Publishers, 2011)In the present study, cyclosporine A (CsA) was incorporated successfully into cationic Eudragit(R) RS 100 nanoparticles (EPNs) aiming ocular application. Physicochemical characterization of the EPNs prepared was performed ... -
Preparation and in vitro evaluation of pyridostigmine bromide microparticles
Hegazy, N; Demirel, Müzeyyen; Yazan, Yasemin (Elsevier Science BV, 2002)Pyridostigmine bromide (PB) is an anticholinesterase agent whose aqueous solubility is high and which has a short elimination half-life. Its dosage rate in the treatment of myastenia gravis is frequent due to the short ... -
Preparation and In-Vitro Dissolution of Salbutamol Sulfate Microcapsules and Tabletted Microcapsules
Yazan, Yasemin; Demirel, Müzeyyen; Güler, E (Taylor & Francis LTD London, 1995)Salbutamol sulphate is a sympathomimetic amine having a rather short plasma half-life. Aiming to achieve sustained release of this drug through microencapsulation, the coacervation method with a 1:1 core-shell ratio was ... -
Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation
Genç, Lütfi; Demirel, Müzeyyen; Yazan, Yasemin (Pharmaceutical Soc Korea, 2006)Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, ... -
Preparation, characterization and pharmacokinetic evaluation of rosuvastatin calcium incorporated cyclodextrin-polyanhydride nanoparticles
Al-Heibshy, Fawaz N. S.; Başaran, Ebru; Arslan, Rana; Öztürk, Naile; Vural, İmran; Demirel, Müzeyyen (Taylor & Francis LTD, 2019)Objective: The aim of the study was to formulate, cyclodextrin (CD)-polyanhydride (PA) nanoparticles (CPNs) with rosuvastatin calcium (RCa) in order to enhance the poor oral bioavailability. Methods: CPNs containing RCa/CD ...
