Yazar "Dikmen, Miriş" için listeleme
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Angiotensin II Type 1 Receptor (AT1) Gene A1166C Is Associated with the Risk of Hypertension
Bayramoğlu, Ayşegül; Kurt, Hülyam; Güneş, Hasan Veysi; Ata, Necmi; Birdane, Alparslan; Dikmen, Miriş; Değirmenci, İrfan (Mary Ann Liebert, Inc, 2015)Aim: This study was performed on primary hypertension patients in a Turkish population to determine the frequency of the A1166C polymorphism in the angiotensin II type 1 receptor (AT1) gene and to examine the role of this ... -
Antiangiogenic and antiproliferative effects of halotolerant Penicillium chrysogenum var. chrysogenum on the human umbilical vein endothelial cells (HUVECs)
Dikmen, Miriş; Cantürk, Zerrin; Engür, Selin; Demirtaş, Buket; İlhan, Semra (IEEE, 2013)Inhibitors of angiogenesis have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. In this study was to investigate the ... -
The Antioxidant Potency of Punica granatum L. Fruit Peel Reduces Cell Proliferation and Induces Apoptosis on Breast Cancer
Dikmen, Miriş; Öztürk, Nilgün; Öztürk, Yusuf (Mary Ann Liebert Inc, 2011)Pomegranate (Punica granatum L.) is known to possess pharmacological activities, such as antioxidant and anticancer. In this study, we evaluated the antioxidant potency of a methanolic pomegranate fruit peel extract (PPE) ... -
Antioxidant properties of halotolerant Penicillium chrysogenum var. chrysogenum secondary metabolites
Cantürk, Zerrin; Dikmen, Miriş; Öztürk, Nilgün; Kocabiyik, Ercin; İlhan, Semra (IEEE, 2013)In this study it was aimed at evaluating antioxidant potential of Penicillium sp. broth filtrate and extract. In our study we examined broth filtrate DPPH and free radical scavenging activity, and also total phenol content ... -
Antioxidant, Antiproliferative and Apoptotic Effects of Secondary Metabolites of Halotolerant Aspergillus terreus on Colon Adenocarcinoma Caco-2 Cells
Dikmen, Miriş; Cantürk, Zerrin; Artagan, Oge; Öztürk, Nilgün (Asian Network Scientific Information-Ansinet, 2017)Objective: This study aimed to investigate the antioxidant and anticancer effects of the secondary metabolites of halotolerant Aspergillus terreus-2 (hAt-2) on colon adenocarcinoma (Caco-2) cells. The hAt-2 was isolated ... -
Antiproliferative and Apoptotic effects of Aprepitant on Human Glioblastoma U87MG Cells
Dikmen, Miriş (Marmara University, Fac Pharmacy, 2017)Glioblastoma multiforme, is the most malignant glioma among other gliomas with high incidence. It has aggresive properties such as high proliferation, invasion and migration rates. Therefore, recently studies have focused ... -
Camellia sinensis (çay) ekstrelerinin in vitro antioksidan , yara iyileştirici ve U2OS osteosarkom hücrelerinde antikanser aktivitelerinin araştırılması
Er, Sinem (Anadolu Üniversitesi, 2010)Camellia sinensis (L.) Kuntze (Theaceae) (çay), polifenollerce zengin bir bitki olup, özellikle de flavan-3-ol (kateşin) ve flavonol glikozidleri içerir. C. sinensis’den elde edilen yeşil çayın, içerdiği polifenoller ... -
Camellia sinensis increased apoptosis on U2OS osteosarcoma cells and wound healing potential on NIH3T3 fibroblast cells
Er, Sinem; Dikmen, Miriş (Springer, 2017)Camellia sinensis (Cs) is a plant which is rich in polyphenols and has antioxidant, antiinflammatory, antimutagenic, anticarcinogenic and antibacterial activities. In this study, two different methanol extracts (Cs-I and ... -
Comparative Studies on Phenolic Composition, Antioxidant, Wound Healing and Cytotoxic Activities of Selected Achillea L. Species Growing in Turkey
Ağar, Osman Tuncay; Dikmen, Miriş; Öztürk, Nilgün; Yılmaz, Mustafa Abdullah; Temel, Hamdi; Türkmenoğlu, Fatma Pınar (MDPI AG, 2015)Turkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata ... -
Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells
Engür, Selin; Dikmen, Miriş; Öztürk, Yusuf (Taylor & Francis LTD, 2016)Inhibition of the proteasome has emerged as a clinically effective anticancer therapeutic approach in recent years. Bortezomib (Velcade (R)) showed extremely high potency against a wide range of cancer cell lines. Ixazomib ... -
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth
Dikmen, Miriş (Mary Ann Liebert, Inc, 2017)DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel drugs, especially for neurodegenerative disorders. In recent years, there has been increased interest in small molecules that can ... -
Cytotoxic and apoptotic effects of pomegranate peel extract on MCF-7 breast cancer cells
Dikmen, Miriş; Öztürk, Nilgün; Öztürk, Yusuf (Taylor & Francis LTD, 2009)… -
Cytotoxic and inhibitory effects of pomegranate peel extract on proliferation of MCF-7 cells [Nar meyve kabugu ekstresi·ni·n mcf-7 hücre proli·ferasyonu üzeri·ne si·totoksi·k ve i·nhi·bi·tör etki·leri·]
Dikmen, Miriş; Öztürk, Nilgün; Öztürk, Yusuf (2008)The Pomegranate (Punica granatum L.) is a wonderful fruit which contains a wide variety of precious phytochemical compounds applicable in the fields of therapeutics and health care. Previous studies have demonstrated the ... -
Cytotoxic Effects of Resveratrol, Rutin and Rosmarinic Acid on ARH-77 Human (Multiple Myeloma) Cell Line
Cantürk, Zerrin; Dikmen, Miriş; Artagan, Oge; Özarda, Mustafa Güçlü; Öztürk, Nilgün (Natural Products Inc, 2016)Multiple myeloma (MM) cancers are 10% of hematological cancers. Leukemia ARH-77 is' a malignancy like MM with a worse course of disease and the survival rate from it is very low. Therefore, ARH-77 is a commonly used model ... -
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Tilki, Elif Kaya; Dikmen, Miriş (MDPI, 2018)Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. ... -
DNA metiltransferaz inhibitörü RG108 ve histon deasetilaz inhibitörü trikostatin A'nın nörit gelişiminde epigenetik etkilerinin karşılaştırılması
Kaya, Elif (Anadolu Üniversitesi, 2014)Nörodejeneratif hastalıkların nöropatolojisi genel olarak, beynin spesifik bölgelerindeki spesifik nöronların kaybı veya atrofisi ile ilişkilendirilir. Rejenerasyonun olmayışı; hasarlı nöronların ölümü, rejenerasyon ... -
Dopamine D2 receptor gene-141C Insertion/Deletion polymorphism in Turkish schizophrenic patients
Kurt, Hülyam; Dikmen, Miriş; Başaran, Ayşe; Yenilmez, Çınar; Özdemir, Figen; Değirmenci, İrfan; Mutlu, Fezan (Springer, 2011)Schizophrenia is a chronic and neuropsychiatric disease that affects about 0.5-1% of the world's population. An increase in dopamine and dopamine D2 receptor (DRD2) gene products has been well described in schizophrenic ... -
Effect of mianserin on streptozotocin-induced hyperglycemia and metabolic alterations in rats
Can, Özgür Devrim; Üçel, İrfan Umut; Özkay, Ümide Demir; Dikmen, Miriş (Çukurova University, Fac Medicine, 2017)Purpose: The aim of this study was to investigate possible effects of atypical antidepressant mianserin on glycemia levels and metabolic parameters of normoglycemic and diabetic rats Material and Methods: Effects of mianserin ...
