Yazar "Isik, Mesut" için listeleme
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AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress
Isik, Mesut; Beydemir, Sukru (Taylor & Francis Ltd, 9999)Oxidative metabolic reactions and their by products have played a role in coronary artery disease (CAD) and Alzheimer's disease (AD) pathogenesis. This study was carried out on 28 patients with AD, 21 patients with CAD, ... -
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Isik, Mesut; Beydemir, Sukru; Demir, Yeliz; Durgun, Mustafa; Turkes, Cuneyt; Nasir, Abdul; Akkus, Musa (Elsevier, 2020)Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as antimicrobial drugs for a long time. in the present study, we investigated in vitro inhibitory activities of benzenesulfonamide derivatives ... -
Molecular docking and investigation of 4-(benzylideneamino)- and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors
Isik, Mesut; Demir, Yeliz; Durgun, Mustafa; Turkes, Cuneyt; Necip, Adem; Beydemir, Sukru (Springer International Publishing Ag, 2020)The discovery of acetylcholinesterase inhibitors is important for the treatment of Alzheimer's disease (AD), known as the most common type of dementia. Due to the side effects of commonly used acetylcholinesterase inhibitors, ... -
Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases
Durgun, Mustafa; Turkes, Cuneyt; Isik, Mesut; Demir, Yeliz; Sakli, Ali; Kuru, Ali; Supuran, Claudiu T. (Taylor & Francis Ltd, 2020)Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, C-13 NMR, H-1 NMR, LC-MS and ... -
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
Isik, Mesut; Akocak, Suleyman; Lolak, Nabih; Taslimi, Parham; Turkes, Cuneyt; Gulcin, Ilhami; Beydemir, Sukru (Wiley-V C H Verlag Gmbh, 9999)In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their ... -
Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, ?-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs
Lolak, Nebih; Akocak, Suleyman; Turkes, Cuneyt; Taslimi, Parham; Isik, Mesut; Beydemir, Sukru; Durgun, Mustafa (Academic Press Inc Elsevier Science, 2020)…
