Yazar "Kabadere, Selda" için listeleme
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Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro
Kuş, Gökhan; Özkurt, Mete; Kabadere, Selda; Erkasap, Nilüfer; Göğer, Gamze; Demirci, Fatih (Comenius University, 2018)OBJECTIVES: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma, T98; prostate, LnCaP) as well as mouse embryonic fi broblast cell lines (3T3), and ... -
Ceranib-2 induces apoptosis in prostate cancer cells
Kuş, Gökhan; Kabadere, Selda; Kutlu, Hatice Mehtap; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Ceranib-2 inhibits the proliferation and induces apoptosis of glioma cells in vitro
Kabadere, Selda; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Comparing the Role of Silymarin on Survival Rate of Rat Glioma With Primary Mixed Rat Glia Cells in Vitro
Gezgin, Duygu; Kabadere, Selda; Uyar, Ruhi; Kuş, Gökhan (Parlar Scientific Publications (PSP), 2013)Phytochemicals, nutraceuticals and herbal products, such as silymarin, have gained ever growing popularity and are valued for their ability to defend against almost all types of disease. Primarily known as hepatoprotective ... -
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells
Kuş, Gökhan; Özkurt, Mete; Öztopçu Vatan, Pınar; Erkasap, Nilüfer; Uyar, Ruhi; Kabadere, Selda (Tubitak Scientific & Technical Research Council Turkey, 2018)Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. Thus, we examined the possible role of ceranib-2, a novel ceramidase inhibitor, on growth and ... -
Cytotoxic and apoptotic effects of ceranib-2 offering potential for a new antineoplastic agent in the treatment of cancer cells
Vejselova, Djanan; Kutlu, Hatice Mehtap; Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi (Tubitak Scientific & Technical Research Council Turkey, 2014)Fibrocarcinomas are malignant tumours that originate in mesenchymal cells. The tumours typically form in the presence of connective tissue and are of key consideration when assessing research priorities for future healthcare ... -
Cytotoxic and Apoptotic Functions of Licofelone on Rat Glioma Cells
Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi; Kabadere, Selda (Akademiai Kiado Zrt, 2013)Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase and lipoxygenase pathways that take role in arachidonic acid ... -
The effect of R547, a cyclin-dependent kinase inhibitor, on hepatocellular carcinoma cell death
Hacioglu, Betul; Kus, Gokhan; Kutlu, Hatice Mehtap; Kabadere, Selda (Tubitak Scientific & Technical Research Council Turkey, 2020)Hepatocellular carcinoma (HCC) is the third main cause of cancer-related death. Cyclin-dependent kinases (CDKs) and their cyclin partners regulate the cell cycle. Since inhibition of CDKs gives some guiding ideas for cancer ... -
The effects of ceranib-2 on cancer and non-cancer cell morphology
Kutlu, Hatice Mehtap; Vejselova, Djanan; Kuş, Gökhan; Cengiz, Mustafa; Kabadere, Selda (Wiley-Blackwell, 2014)… -
The effects of ceranib-2 on cancer and non-cancer cell ultrastructure
Vejselova, Djanan; Kuş, Gökhan; Kutlu, Hatice Mehtap; Cengiz, Mustafa; Kabadere, Selda (Wiley-Blackwell, 2014)… -
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line
Başpınar, Mustafa Serhat; Özyurt, Rumeysa; Kuş, Gökhan; Kutlay, Özden; Özkurt, Mete; Erkasap, Nilüfer; Kabadere, Selda (Comenius University, 2017)OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. MATERIALS AND METHODS: The cell lines were treated ... -
Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2
Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi; Kutlu, Hatice Mehtap (Springer, 2015)Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential ... -
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis
Kabadere, Selda; Kuş, Gökhan; Uyar, Ruhi; Öztopçu-Vatan, Pınar (Informa Healthcare, 2014)Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways ... -
MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro
Kabadere, Selda; Öztopçu, P.; Korkmaz, S.; Erol, K.; Uyar, R. (2004)In this study, the possible effects of MgSO 4 and lazaroid (U-83836E) on glutamate toxicity on glial cells were investigated. C6 and human glioblastoma multiforme cells derived from two patients were grown in an incubator. ... -
Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines
Ertekin, Rıfat; Özkurt, Mete; Kuş, Gökhan; Kabadere, Selda (Zoological Soc Pakistan, 2019)Prostate cancer is a common type of cancer. Contemporary treatment modalities require that new, effective methods or chemicals should be developed. Tolfenamic acid (TA) is a nonsteroidal anti-inflammatory medicine stimulating ... -
Screening of Antimicrobial, Cytotoxic Effects and Phenolic Compounds of the Moss Aulacomnium Androgynum (Hedw.) Schwagr (Bryophyta)
Öztopçu-Vatan, Pınar; Savaroğlu, F.; İşcen, C. F.; Kabadere, Selda; Öztürk, Nilgün; İlhan, S. (Pakistan Agricultural Scientists Forum, 2017)The second largest taxonomic group in the kingdom plantae is bryophytes, however; studies carried out to better understand their chemical composition are limited and dispersed. In this study, phenolic compounds, the ... -
Screening of antimicrobial, cytotoxic effects and phenolic compounds of the moss Dicranum scoparium
Bryophytes belong to the group of the oldest known land plants, which includes liverworts, hornworts, and mosses. Recent research shows that mosses contain remarkable and unique substances with high biological activity. ... -
Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Kabadere, Selda; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory ...
