Yazar "Karaca Gencer, Hülya" için listeleme
-
Antimicrobial and anticancer effects of some 2-(substitutedsulfanyl)-N-(5-methyl-isoxazol-3-yl)acetamide derivatives
Özkay, Yusuf; Seller, Zerrin; Önder, Nur İpek; Tunalı, Yağmur; Karaca Gencer, Hülya; Işıkdağ, İlhan; Uçucu, Ümit (Springer Birkhauser, 2013)In the present study, some isoxazole-(benz)azole derivatives (3a-3j) were synthesized by considering antimicrobial and anticancer potencies of azole compounds. Chemical structures of obtained compounds (3a-3j) were confirmed ... -
Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
Turan, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Bir hücre fabrikası olarak Saccharomyces cerevisiae’da metabolizma mühendisliği stratejileri kullanarak taksol üretimi
Karaca Gencer, Hülya; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmasötik Mikrobiyoloji Anabilim Dalı; Morçal, Özlem (Tez (yüksek lisans) - Anadolu Üniversitesi, 2019)İzoprenoidler doğada birçok yerde bulunmaktadır ve temel hücre bileşenlerinden ikincil metabolitlere kadar çeşitlilik göstermektedir. Terpenoidler (izoprenoidler) gibi doğal ürünler genellikle orijinal kaynaklarından ... -
Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties
Karaman, Nurcan; Zainel, Rabeah Adil; Kapkac, Handan A.; Karaca Gencer, Hülya; Ilgın, Sinem; Karaduman, Abdullah Burak; Koçyiğit-Kaymakçıoğlu, Bedia (Wiley-V C H Verlag GMBH, 2018)1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1-22) were obtained by the reaction of ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
Kaya, Betül; Hussin, Weiam; Yurttaş, Leyla; Turan, Gülhan; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)A series of 2-(4-substitutedmethylphenyl) propionic acid derivatives (6a-6m) were synthesized, characterized and evaluated for cyclooxygenase (COX) enzyme inhibitory and antimicrobial activity. Test compounds that exhibited ... -
New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors
Karaca Gencer, Hülya; Levent, Serkan; Çevik, Ulviye Acar; Özkay, Yusuf; Ilgın, Sinem (Pergamon-Elsevier Science LTD, 2017)Owing to the growing need for novel antibacterial agents, we synthesized a novel series of fluoroquinolones including 7-substituted-1-(2,4-difluoropheny1)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ... -
New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Öztürk, Yusuf (MDPI AG, 2017)Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substituted phenyl)ethan-1-one derivatives, ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
Novel imidazole derivatives as antifungal agents: Synthesis, biological evaluation, ADME prediction and molecular docking studies
Altındağ, Firuze Diyar; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Işıkdağ, İlhan; Özkay, Yusuf; Karaca Gencer, Hülya (Taylor & Francis LTD, 2019)A series of 2-(substituteddithiocarbamoyl)-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide derivatives was designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. All synthesized ... -
Reboksetin kullanımının bağırsak florası üzerine etkisinin biyoinformatik analizi
Karaca Gencer, Hülya; Özkul Koçak, Ceren; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmasötik Mikrobiyoloji Anabilim Dalı; Tekinkoca, Sinem (Tez (yüksek lisans) - Anadolu Üniversitesi, 2019)Mikrobiyom insan vücudunun en karmaşık bileşenleri arasında yer almaktadır. İkinci beyin olarak adlandırılan bağırsak florası en fazla sayıda ve çeşitlilikte mikrorganizma barındırmaktadır. Hastalıklar ve hastalıkların ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Biological Evaluation of Pyrazoline Derivatives Bearing an Indole Moiety as New Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Karaca Gencer, Hülya; Tunalı, Yağmur (Wiley-V C H Verlag GMBH, 2013)1-(p-Methylphenyl)-3,5-diaryl-2-pyrazoline derivatives (2a-f) were synthesized via the treatment of 1-(1H-indol-3-yl)-3-aryl-2-propen-1-ones (1a-f) with p-methylphenylhydrazine hydrochloride in hot acetic acid. The structures ... -
Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
Abu Mohsen, Usama; Yurttaş, Leyla; Acar, U.; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Karaca Gencer, Hülya; Cantürk, Zerrin (Georg Thieme Verlag Kg, 2015)In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]- ... -
Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
Sağlık, Begüm Nurpelin; Özkay, Yusuf; Özkay, Ümide Demir; Karaca Gencer, Hülya (Hindawi LTD, 2014)18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
Yurttaş, Leyla; Duran, Murat; Demirayak, Şeref; Karaca Gencer, Hülya; Tunalı, Yağmur (Pergamon-Elsevier Science LTD, 2013)In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the ... -
Synthesis of New Thiazolyl-pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects
Sever, Belgin; Altıntop, Mehlika Dilek; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve; Özdemir, Ahmet (Bentham Science Publ LTD, 2018)Background: Pyrazolines have played a pivotal role in antimicrobial and anticancer drug discovery. Moreover, thiazoles have attracted a great deal of interest due to their crucial roles in the lead identification and ... -
Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation
Yurttaş, Leyla; Özkay, Yusuf; Karaca Gencer, Hülya; Acar, Ulviye (Hindawi LTD, 2015)New 2-(4-arylpiperazine-1-yl)-N-[4-(2-(4-substituted phenyl)thiazol-4-yl)phenyl]acetamide derivatives were synthesized and evaluated for their antimicrobial and anticholinesterase activities. Acetylcholinesterase inhibitory ... -
Synthesis of thiazole-phenylacetic acid compounds as dual antibacterial-COX enzymes inhibitors
Karaca Gencer, Hülya (Çukurova University, Fac Medicine, 2017)Purpose: Present a new potential dual drug for patient suffering both inflammation and infection was aim of this study therefore investigation of anti-inflammatory and antimicrobial activity of new thiazole-phenylacetic ... -
Synthesis, Antituberculotic, and Cytotoxic Properties of New Hydrazone Derivatives Bearing Pyrimidine-Alkylsulfanyl Moiety
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Cantürk, Zerrin; Karaca Gencer, Hülya (Taylor & Francis LTD, 2015)A series of N'-(arylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide derivatives (3a-3m) has been synthesized and investigated for their antituberculotic and cytotoxic activity. The antitubercular activities of the newly ...
