Yazar "Karaduman, Abdullah Burak" için listeleme
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Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties
Karaman, Nurcan; Zainel, Rabeah Adil; Kapkac, Handan A.; Karaca Gencer, Hülya; Ilgın, Sinem; Karaduman, Abdullah Burak; Koçyiğit-Kaymakçıoğlu, Bedia (Wiley-V C H Verlag GMBH, 2018)1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1-22) were obtained by the reaction of ... -
Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new
Anadolu Üniversitesi; 0009-0003-0969-0474; 0000-0001-7331-1975; 0000-0002-3646-7935; 0000-0002-8099-0942; 0000-0002-0434-1334; 0000-0002-6131-3399; Farmanlı, Gülnar; Ilgın, Sinem; Ergun, Bülent; Baysal, Merve; Karaduman, Abdullah Burak; Atlı Eklioğlu, Özlem (Anadolu Üniversitesi, 2023)Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the ... -
Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer's disease
Cevik, Ulviye Acar; Osmaniye, Derya; Saglik, Begum Nurpelin; Cavusoglu, Betul Kaya; Levent, Serkan; Karaduman, Abdullah Burak; Turan, Gulhan (Springer Birkhauser, 2020)Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
Atlı Eklioğlu, Özlem; Baysal, Merve; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Karaduman, Abdullah Burak; Ilgın, Sinem (Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Karaduman, Abdullah Burak; Kaplancıklı, Zafer Asım (MDPI, 2018)Twenty-six novel thiosemicarbazone derivative B1-B26 were synthesized via condensation reactions between the corresponding thiosemicarbazides and aldehydes. The chemical characterization of the compounds was carried out ... -
Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs
Turan, Gülhan; Tabbi, Aouatef; Hussein, Weiam; Karaduman, Abdullah Burak; Sağlık, Begüm Nurpelin; Özkay, Yusuf (Hindawi LTD, 2018)A series of N-[1-(((3,4-diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide derivatives (4a-4i) were synthesized in good yield and assayed for their inhibitory potency against monoamine oxidase (MAO) isoforms. ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Zonisamidin reprodüktif toksisitesinin erkek sıçanlarda değerlendirilmesi
Ilgın, Sİnem; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü; Karaduman, Abdullah Burak (Tez (yüksek lisans) - Anadolu Üniversitesi, 2018)Epilepsi tedavisinde sıklıkla reçete edilen antiepileptik ilaç olarak zonisamidin (ZNS) erkeklerde seksüel fonksiyon bozukluklarına neden olduğu rapor edilmekle birlikte erkek reprodüktif sistem üzerine toksik etkilerinin ...
