Browsing by Author "Katritzky, Alan R."
Now showing items 1-12 of 12
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Benzotriazole-mediated amidoalkylations of nitroalkanes, nitriles, alkynes and esters
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Çelik, İlhami (Arkat Usa Inc, 2007)Reactions of readily available and stable N-(alpha-amidoalkyl)benzotriazoles 1 ( derived from a variety of aliphatic, aromatic or heterocyclic aldehydes) with diverse nitroalkanes, nitriles, alkynes and esters afforded ... -
Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters
Avan, İlker; Tala, Srinivasa R.; Steel, Peter J.; Katritzky, Alan R. (American Chemical Society, 2011)Reactions of O-Pg(alpha-hydroxyacyl)benzotriazoles with (a) unprotected alpha-hydroxycarboxylic acids, (b) amino acids, and (c) amines afforded, respectively, chirally pure (a) oligoesters, (b) depsidipeptides, and (c) ... -
Benzotriazole-Mediated Synthesis of Aza-peptides: En Route to an Aza-Leuenkephalin Analogue
Abo-Dya, Nader E.; Biswas, Suvendu; Başak, Akash; Avan, İlker; Alamry, Khalid A.; Katritzky, Alan R. (American Chemical Society, 2013)Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with alpha-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide 23b, and alpha-hydroxy-beta-phenylpropionic acid 27 yielding, ... -
Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41
Jiang, Shibo; Tala, Srinivasa R.; Lu, Hong; Zou, Peng; Avan, İlker; İbrahim, Tarek S.; Katritzky, Alan R. (Pergamon-Elsevier Science LTD, 2011)Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a-h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki-Miyaura cross coupling, followed by ... -
Efficient preparation of aminoxyacyl amides, aminoxy hybrid peptides and a-aminoxy peptides
Tala, Srinivasa R.; Avan, İlker; Katritzky, Alan R. (American Chemical Society, 2010)… -
Efficient Preparation of Aminoxyacyl Amides, Aminoxy Hybrid Peptides, and alpha-Aminoxy Peptides
Katritzky, Alan R.; Avan, İlker; Tala, Srinivasa R. (American Chemical Society, 2009)N-(Pg-alpha-aminoxy acids) 1a-g are converted to N-(Pg-alpha-aminoxyacyl)benzotriazoles 2a-g, Which react under mild conditions with amines, alpha-amino acids/alpha-dipeptides, and alpha-aminoxy acids to give aminoxyacyl ... -
gNMR simulated H-1 and proton-coupled C-13 NMR spectra of substituted 3-nitropyridines. GIAO/DFT calculated values of proton and carbon chemical shifts and coupling constants
Katritzky, Alan R.; Akhmedov, Novruz G.; Güven, Alaattin; Doskocz, J; Akhmedova, RG; Majumder, S; Hall, CD (Elsevier Science BV, 2006)The magnitude of one bond and long-range coupling constants in 3-nitropyridine 1 and its derivatives 2-16 were determined from the proton-coupled C-13 NMR spectra in CDCl3. The GIAO/DFT (Density Functional Theory/Gauge ... -
NMR spectra, GIA and charge density calculations of five-membered aromatic heterocycles
Katritzky, Alan R.; Akhmedov, Novruz G.; Doskocz, Jacek; Mohapatra, Prabhu P.; Hall, C. Dennis; Güven, Alaattin (Wiley-Blackwell, 2007)The B3LYP/6-31+G(d) molecular geometry optimized structures of 17 five-membered heterocycles were employed together with the gauge including atomic orbitals (GIAO) density functional theory (DFT) method at the B3LYP/6-31+G(d,p), ... -
One-bond and long-range coupling constants of substituted 2-cyanopyridines. GIAO/DFT calculations of proton and carbon chemical shifts and coupling constants
Katritzky, Alan R.; Akhmedov, Novruz G.; Güven, Alaattin; Scriven, EFV; Majumder, S; Akhmedova, RG; Hall, CD (Elsevier Science BV, 2006)The magnitude of one bond and long-range coupling constants ((n)J(HH) and (n)J(CH)) in isomeric cyanopyridines-(1, 2, 3), methyl-(4, 5, 6, 7), 3-ethyl-(8), chloro-(9), 3-bromo-(10), acetyl-(11, 12), 5-ethoxycarbonyl-(13) ... -
Peptidomimetics via modifications of amino acids and peptide bonds
Avan, İlker; Hall, C. Dennis; Katritzky, Alan R. (Royal Soc Chemistry, 2014)Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, ... -
Photophysics of novel coumarin-labeled depsipeptides in solution: sensing interactions with SDS micelle via TICT model
Biswas, Suvendu; Avan, İlker; Başak, Akash; Abo-Dya, Nader E.; Asiri, Abdullah; Katritzky, Alan R. (Springer Wien, 2013)N-Acylbenzotriazoles enable the synthesis (69-92 % yield) of blue to green fluorescent coumarin-labeled depsidipeptides 8a-f (quantum yields 0.004-0.97) and depsitripeptides 12a-d (quantum yields 0.02-0.96). Detailed ... -
Thioamidoalkylation of 1,3-dicarbonyl compounds, enol silyl ethers, and enamines
Katritzky, Alan R.; Çelik, İlhami; Abdel-Fattah, Ashraf A. A. (Georg Thieme Verlag Kg, 2007)Novel syntheses of beta-thioamido ketones via thioamidoalkylations of malonates, beta-keto esters, beta-diketones, enol silyl ethers, and enamines with N-(alpha-thioamidoalkyl)benzotriazoles are described.
